SOST Inhibits Prostate Cancer Invasion. [PDF]
PLoS ONE, 2015 Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored.
Bryan D Hudson +8 more
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Transcriptional control of Sost in bone [PDF]
Bone, 2017 Sclerostin is an osteocyte derived negative regulator of bone formation. A highly specific expression pattern and the exclusive bone phenotype have made Sclerostin an attractive target for therapeutic intervention in treating metabolic bone diseases such as osteoporosis and in facilitating fracture repair.
Sebastian, Aimy, Loots, Gabriela G.
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Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene [PDF]
Bone, 2016 SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression.
Lhaneche, Leila +13 more
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Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice [PDF]
Scientific Reports, 2020 Loss-of-function mutations in the Sost gene lead to high bone mass phenotypes. Pharmacological inhibition of Sost/sclerostin provides a new drug strategy for treating osteoporosis.
Haisheng Yang +10 more
doaj +4 more sources
SOST is a target gene for PTH in bone [PDF]
Bone, 2005 Intermittent parathyroid hormone (PTH) application is an established pharmacological principle to stimulate bone formation. Yet, the molecular mechanisms underlying this bone anabolic action are not fully understood. Recently, SOST (sclerostin) was identified as a potent osteocyte expressed negative regulator of bone formation in vitro, in murine ...
Hansjoerg, Keller, Michaela, Kneissel
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Preaxial Polydactyly in Sost/Sostdc1 Double Knockouts [PDF]
, 2011 In the United States, {approx}5% are born with congenital birth defects due to abnormal function of cellular processes and interactions. Sclerosteosis, a rare autosomal recessive disease, causes hyperostosis of the axial and appendicular skeleton, and patients present radial deviation, digit syndactyly, nail dysplasia, and overall high bone mineral ...
Yee, C M, Collette, N M, Loots, G G
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Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling. [PDF]
PLoS ONE, 2017 Connexin43 (Cx43) is the main gap junction protein expressed in bone forming cells, where it modulates peak bone mass acquisition and cortical modeling.
Susan K Grimston +3 more
doaj +3 more sources
Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene [PDF]
International Journal of Genomics, 2019 Purpose. SOST gene is one of the key factors in regulating bone absorption. Although there are reports showing diverse transcription factors, epigenetic modification could be responsible for regulating SOST gene expression.
Yanming Cao +10 more
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Role of SOST in Response to Mechanical Stimulation in Bone and Extraosseous Organs
BiomoleculesSclerostin (SOST) is a specific osteocyte protein. During the differentiation and proliferation of osteoblasts and osteoclasts, the high expression of SOST can inhibit bone formation and contribute to osteoporosis and the bone metastasis of malignant ...
Minyou Chen +3 more
doaj +3 more sources
EFFECT OF PKP ON SERUM SOST IN PATIENTS WITH VERTEaBRAL COMPRESSION FRACTURES [PDF]
Acta Ortopédica Brasileira, 2020 Objective: This study sought to determine serum sclerostin (SOST) expression in patients with osteoporotic thoracolumbar vertebral compression fractures before and after percutaneous kyphoplasty (PKP). Methods: Serum SOST levels were quantified with a
ENZHI WANG +4 more
doaj +6 more sources