Results 51 to 60 of about 11,099 (162)

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

Generation of Sost-Cre transgenic mice.

, 2015
(A) Diagram of a portion of the Sost-Cre transgene construct used to generate Sost-Cre transgenic mice. UTR, untranslated region, IRES, internal ribosome entry site, GFP::Cre, fusion protein of GFP and the Cre recombinase.
Josh Campbell (798497), Stavros C. Manolagas (198084), Charles A. O’Brien (798500), Joseph J. Goellner (271077), Melda Onal (798496), Vladimir Dusevich (798498), Marilina Piemontese (798495), Lynda Bonewald (798499), Jinhu Xiong (798494)   +8 more
core   +1 more source

Sequential Anabolic and Antiresorptive Treatment Promotes Medication‐Related Osteonecrosis of the Jaw in Mice

Oral Diseases, EarlyView.
ABSTRACT Objective To investigate the effects of sequential administration of romosozumab and denosumab on post‐extraction socket healing and osteonecrosis development in a murine tooth extraction model. Methods Forty female mice were randomly assigned to four groups: control (Ctrl), romosozumab (Rm), denosumab (Dmab), and sequential romosozumab ...
Seo‐Yeong An, Hae‐Seo Park, Reuben H. Kim, Moon‐Young Kim   +3 more
wiley   +1 more source

Effect of HIF-1α on Sost promoter activity.

, 2013
(A) HIF-1α activates the Sost promoter in a dose-dependent manner. HEK293 cells were transfected with a 1 kb Sost promoter-luciferase reporter gene without or with increasing amounts of an HIF-1α-expression plasmid as indicated.
Chi Zhang (9857), Yonggang Xing (291915), Zhiyu Zhou (291914), Yang Li (7082), Wei Tian (291921), Xuenong Zou (291919), Chengai Wu (420708), Dafu Chen (291913)   +7 more
core   +1 more source

Long‐term stability of conventional non‐regenerative periodontal treatment for furcation defects

Periodontology 2000, EarlyView.
Abstract Background Furcation involvement (FI) in multi‐rooted teeth poses significant challenges in periodontal therapy due to complex anatomy and difficulty in achieving effective maintenance. FI is associated with increased periodontal destruction, especially in sites with narrow furcation entrances and deep root concavities.
Guo‐Hao Lin, April Martinez, Vincent Li, Eric Lee, Kang‐Wei Tu, Richard Kao, Hom‐Lay Wang   +6 more
wiley   +1 more source

Identification of the minimal region in the promoter of Sost gene for HIF-1α activation.

, 2013
(A) Schematic representation of the Sost deletion mutants. HRE: hypoxia response element. Sost-1 kb, Sost-540 bp, Sost-260 bp and Sost-106 bp Sost promoter reporter plasmids were constructed, using luciferase (LUC) as a reporter. (B) Deletion analysis of
Chi Zhang (9857), Yonggang Xing (291915), Zhiyu Zhou (291914), Yang Li (7082), Wei Tian (291921), Xuenong Zou (291919), Chengai Wu (420708), Dafu Chen (291913)   +7 more
core   +1 more source

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait

Frontiers in Endocrinology
Obesity and Type 2 Diabetes Mellitus (T2DM) are intricate metabolic disorders with a multifactorial etiology, often leading to a spectrum of complications.
Tahani Alramah, Preethi Cherian, Irina Al-Khairi, Mohamed Abu-Farha, Mohamed Abu-Farha, Thangavel Alphonse Thanaraj, Ahmed N. Albatineh, Fayez Safadi, Fayez Safadi, Hamad Ali, Muhammad Abdul-Ghani, Muhammad Abdul-Ghani, Jaakko Tuomilehto, Jaakko Tuomilehto, Jaakko Tuomilehto, Heikki A. Koistinen, Heikki A. Koistinen, Heikki A. Koistinen, Fahd Al-Mulla, Fahd Al-Mulla, Jehad Abubaker   +20 more
doaj   +1 more source

Advanced glycation end products impair bone marrow mesenchymal stem cells osteogenesis in periodontitis with diabetes via FTO-mediated N 6-methyladenosine modification of sclerostin

Journal of Translational Medicine, 2023
Background Diabetes mellitus (DM) and periodontitis are two prevalent diseases with mutual influence. Accumulation of advanced glycation end products (AGEs) in hyperglycemia may impair cell function and worsen periodontal conditions. N 6-methyladenosine (
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Guangyue Li, Leilei Zheng, Jinlin Song   +7 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Close negative correlation of local and circulating Dickkopf-1 and Sclerostin levels during human fracture healing

Scientific Reports
Wnt signaling is critically involved in fracture healing. Existing data predominantly relies on rodent models. Here, we explored local and circulating Dickkopf-1 (DKK1) levels in patients with respect to fracture healing and explore its association to ...
Julia Starlinger, Jonas Santol, Georg Kaiser, Kambiz Sarahrudi   +3 more
doaj   +1 more source