Results 51 to 60 of about 10,314 (209)

Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

BMC Oral Health, 2018
Background To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the ...
Klara Janjić, Barbara Cvikl, Christoph Kurzmann, Andreas Moritz, Hermann Agis   +4 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Methylation of bone SOST impairs SP7, RUNX2, and ERα transactivation in patients with postmenopausal osteoporosis [PDF]

, 2018
Sclerostin (SOST), a glycoprotein predominantly secreted by bone tissue osteocytes, is an important regulator of bone formation, and loss of SOST results in Van Buchem disease.
Shan, Yu, Zhang, Peng, Shen, Guangsi, Li, Guangfei, Xu, Youjia, Wang, Liang   +5 more
core   +2 more sources

Building bone with a SOST-PTH partnership [PDF]

Journal of Bone and Mineral Research, 2010
The discovery of the SOST gene, whose protein product, sclerostin, is an osteocyte-derived inhibitor of Wnt signalling and bone formation, has provided a major advance in bone biology. It gives us new insights into the communicating networks among bone cells and, importantly, to new ways of restoring bone once it has been lost.
openaire   +2 more sources

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source

Sicilian Wineries' Intention to Comply With Sustainability Certification as a Strategic Business Behavior

Sustainable Development, EarlyView.
ABSTRACT The present study explores the factors influencing Sicilian wineries' willingness to adopt sustainability certification, which represents an increasingly relevant tool for enhancing the environmental, social, and economic performance viticulture's sector.
Alessandro Scuderi, Gaetano Chinnici, Roberta Maria Gravagno, Giulio Cascone, Carla Zarbà   +4 more
wiley   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, EarlyView.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia [PDF]

, 2011
Sclerosteosis and Van Buchem disease are related recessive sclerosing bone dysplasias caused by alterations in the SOST gene. We tested the hypothesis that craniodiaphyseal dysplasia (CDD) (MIM 122860), an extremely rare sclerosing bone dysplasia ...
Ah-Ra Ko, Ok-Hwa Kim, Andrea Superti-Furga, Kazimierz Kozlowski, Okamoto, N, Ko, AR, Bieganski, T, Kim, OH, Kozlowski, K, Kim, SJ, Sohn, YB, Yoon-La Choi, Ahn, GH, Gen Nishimura, Superti-Furga, A, Chi Hwa Kim, Choi, YL, Young Bae Sohn, Mikhail Semënov, Chang-Seok Ki, Sheila Unger, Geung Hwan Ahn, Su Jin Kim, Ki, CS, Nishimura, G, Jin, DK, Park, SW, Sung Won Park, Semënov, M, Tadeusz Bieganski, Nobuhiko Okamoto, Kim, CH, Unger, S, Dong-Kyu Jin   +33 more
core   +1 more source

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, EarlyView.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Cbfa1/RUNX2 Directs Specific Expression of the Sclerosteosis Gene (SOST) [PDF]

Journal of Biological Chemistry, 2004
Loss-of-function mutations in the sclerosteosis gene (SOST) cause a rare sclerosing bone dysplasia characterized by skeletal overgrowth. Cbfa1/RUNX2 is a key transcriptional regulator of osteoblast function. Here we link these two pathways by demonstrating, via gel shift and transient transfection analyses, that Cbfa1 binding to the proximal SOST ...
Brad, Sevetson, Scott, Taylor, Yang, Pan
openaire   +2 more sources