Results 71 to 80 of about 11,099 (162)

Effects of Zhuang Gu Zhi Tong Formula on Wnt/β-catenin Osteoporosis Pathway Antagonist SOST in Osteoporosis

Digital Chinese Medicine, 2019
Objective: To observe the effects of Zhuang Gu Zhi Tong Formula (ZGZTF) on antagonist SOST in canonical Wnt/β-catenin signaling pathway in osteoporosis.
Liu Xiang-Lin, Liu Le-Ping, He Rong, Zhang Shu-Qi, Zhao Zi-Yi, Peng Ting, Liu Hui-Ping, Zhang Guo-Min   +7 more
doaj   +1 more source

Global Surgery at the Frontlines of Conflict Zones: Role of Health Diplomacy in the Provision of On‐Site Surgical Care to Children

World Medical &Health Policy, Volume 18, Issue 3, September 2026.
ABSTRACT Confrontational violence still puts catastrophic burdens on children, with 2024 being the highest recorded levels of displacement, malnutrition, injury, and deprivation in contemporary humanitarian history. Children's surgical care is still grossly underrepresented in health responses worldwide in the prevention of avoidable deaths and long ...
Gaurav Chanderprakash Mittal, Vijay Kumar Chattu, Alma Nurtazina, Satya Sudhakara Bhatt, Altay Dyussupov   +4 more
wiley   +1 more source

messaletto (sost.), TLIO, Tesoro della lingua italiana delle Origini.

, 2022
Elaborazione voce TLIO, messaletto (sost.)
Jessica Puliero
core  

Associations of serum sclerostin levels with body composition, pulmonary function, and exacerbations in COPD patients

Pulmonology
Background In COPD, the bronchial epithelium shows a pathologically activated Wnt pathway. Sclerostin (SOST) is a secreted glycoprotein that is associated with bone metabolism and blocks the Wnt pathway.
C.A. Amado, M. García-Unzueta, J. Agüero, P. Martín-Audera, P. Fueyo, B.A. Lavín, A.R. Guerra, P. Muñoz, S. Tello, A. Berja, C. Casanova   +10 more
doaj   +1 more source

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

gavettone (sost.), TLIO, Tesoro della lingua italiana delle Origini.

, 2022
Elaborazione voce TLIO, gavettone (sost.)
Puliero Jessica
core  

Patient‐Derived iPSC‐MSC Modelling Reveals Reversible GSK3‐Mediated Suppression of Mesenchymal Lineage Differentiation in Legg‐Calvé‐Perthes Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Legg‐Calvé‐Perthes disease (LCPD) is an idiopathic paediatric osteonecrosis characterized by avascular injury to the femoral head, resulting in structural collapse and early osteoarthritis. Although mesenchymal stem cell (MSC) dysfunction has been implicated, the underlying mechanisms remain unclear due to the absence of human disease models ...
Binna Seol, Hyung Jin Lim, Cho Lok Song, Jungwoon Lee, Yee Sook Cho   +4 more
wiley   +1 more source

Genes Associated With Fracture Risk in Thoroughbred Horses Have Novel Roles in Osteogenesis

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT Bone fractures in Thoroughbred racehorses are a major welfare problem. Genetic factors contribute to fracture risk. Cell models have previously identified 112 differentially expressed genes in bone‐forming osteoblasts derived from horses at high and low genetic risk of fracture. However, 42 of these genes have no published role in bone.
Amy C. Ross, Ellison S. Lumsden, Caroline Flood, Jayesh Dudhia, Androniki Psifidi, Deborah J. Guest   +5 more
wiley   +1 more source

Mechanical Properties of Bone Due to SOST Expression: A 3-Point Bending Assessment of Murine Femurs [PDF]

, 2012
Sclerostin, a protein coded for by the SOST gene, is an osteocyte-expressed negative regulator of bone formation. The absence of SOST in the genome may have an effect on bone formation both during skeletal maturation and full maturity.
Peterson, Kainoa John
core   +1 more source

PO:03:035 | Biomarkers of Gut Epithelial Damage, Microbial Translocation, and Innate Immune Activation Characterize Patients with Axial Psoriatic Arthritis from Psoriasis Patients: Soluble Biomarker Analysis Insights from the ATTRACT Study

Reumatismo
Background. Increasing evidence suggests that axial spondyloarthritis (axSpA) may be associated with intestinal damage, leading to the translocation of bacterial products into the bloodstream and activation of the innate immune system.
Società Italiana di Reumatologia
doaj   +1 more source