Results 71 to 80 of about 10,314 (209)

Quantification of the Tissue Sodium Concentration in the Human Calf at 7T With Reduced Acquisition Time: Influence of the Nominal Spatial Resolution

NMR in Biomedicine, Volume 39, Issue 9, September 2026.
Fast 23Na MRI of the human calf at 7T was achieved by reducing nominal spatial resolution. Shorter measurement times can improve clinical feasibility of 23Na MRI while preserving reliable quantification of apparent tissue sodium concentration through partial volume, relaxation, and B0/B1 corrections.
Jordan M. Höhn, Tobias Wilferth, Lena V. Gast, Teresa Gerhalter, Christoph Kopp, Michael Uder, Armin M. Nagel   +6 more
wiley   +1 more source

SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development [PDF]

, 2007
Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries.
Socrates E. Papapoulos, Conny J. van Munsteren, Michel Aguet, van der Wee-Pals, Lianne, Nathalie Vilain, Aguet, Michel, Christine L. Mummery, Rui M. Monteiro, Vilain, Nathalie, Pancras C.W. Hogendoorn, Clemens W.G.M. Löwik, van Munsteren, Conny J, Papapoulos, Socrates E., Hogendoorn, Paneras C.W., Monteiro, Rui M., Löwik, Clemens W.G.M., Peter Ten Dijke, Mummery, Christine L., Deruiter, Marco C., Ten Dijke, Peter, Hogendoorn, Pancras C. W., Van Bezooijen, Rutger L., Van Munsteren, Conny J., Marco C. DeRuiter, Visser, Annemieke, Annemieke Visser, Lianne van der Wee‐Pals, van Bezooijen, Rutger L, Löwik, Clemens W. G. M., Monteiro, Rui M.; id_orcid, Rutger L. van Bezooijen   +30 more
core   +1 more source

Close negative correlation of local and circulating Dickkopf-1 and Sclerostin levels during human fracture healing

Scientific Reports
Wnt signaling is critically involved in fracture healing. Existing data predominantly relies on rodent models. Here, we explored local and circulating Dickkopf-1 (DKK1) levels in patients with respect to fracture healing and explore its association to ...
Julia Starlinger, Jonas Santol, Georg Kaiser, Kambiz Sarahrudi   +3 more
doaj   +1 more source

Plasma Sclerostin Levels in Rheumatoid Arthritis Women on TNF-α Inhibitor Therapy

Pharmaceuticals
Rheumatoid arthritis (RA) is associated with significant systemic and local bone loss. The aim of this study was to assess whether or not 15-month tumor necrosis factor α inhibitor (TNFαI) therapy in combination with methotrexate (MTX) affects ...
Anna Szeremeta, Agnieszka Jura-Półtorak, Aleksandra Zoń-Giebel, Krystyna Olczyk, Katarzyna Komosińska-Vassev   +4 more
doaj   +1 more source

Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study. [PDF]

PLoS ONE, 2018
Diabetes mellitus represents a major independent risk factor for developing fatal cardiovascular diseases (CVDs) presumably through accelerating atherosclerosis; the underlying cause of most CVDs.
Mona Kamal Saadeldin, Shereen Saeid Elshaer, Ibrahim Ali Emara, Mohamad Maged, Amal Kamal Abdel-Aziz   +4 more
doaj   +1 more source

Genes Associated With Fracture Risk in Thoroughbred Horses Have Novel Roles in Osteogenesis

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT Bone fractures in Thoroughbred racehorses are a major welfare problem. Genetic factors contribute to fracture risk. Cell models have previously identified 112 differentially expressed genes in bone‐forming osteoblasts derived from horses at high and low genetic risk of fracture. However, 42 of these genes have no published role in bone.
Amy C. Ross, Ellison S. Lumsden, Caroline Flood, Jayesh Dudhia, Androniki Psifidi, Deborah J. Guest   +5 more
wiley   +1 more source

Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression. [PDF]

, 2012
Emerging evidence has indicated a role of the bone morphoge-netic proteins (BMP) in the pathogenesis of certain cancers. Thesignaling of BMP family members is tightly regulated by theirantagonists, including noggin and SOST, which are, in turn, posi ...
Kwok-Wah, Chan, Zhang, Shu-Dong, Mohamed, El-Tanani, Glenn, Dickson, Yuen-Piu, Chan, Lok-Yee, Wong Michelle, McCrudden Cian, M., Gopesh, Srivastava, Claire, Grills, Ka-Kui, Chan, Yu-Han, Huang, Hiu-Fung, Yuen, Simon, Law, Fennell Dean, A.   +13 more
core   +4 more sources

Engineering Bone‐Targeted LNP Delivery of Anti‐Sclerostin Antibody mRNA for the Treatment of Osteoporosis

Journal of Biomedical Materials Research Part A, Volume 114, Issue 7, July 2026.
ABSTRACT Messenger RNA (mRNA) therapy represents a transformative platform in regenerative medicine, but its application to skeletal disorders remains limited by the pronounced hepatic tropism of conventional lipid nanoparticle (LNP) delivery systems.
Pengcheng Ren, Diaodiao Wang, Wenqiang Sun, Danning Li, Sidong Yang, Shudong Zhang, Yiquan Zhang, Yubo Liu, Peng Hu, Jiaxin Li, Qi Yao   +10 more
wiley   +1 more source

Expression of SOST/sclerostin in compressed periodontal ligament cells

Journal of Dental Sciences, 2016
Bone resorption and inhibition of bone formation occur on the compressed side during orthodontic tooth movement. Bone formation inhibitory factors such as sclerostin (encoded by SOST) are secreted on the compressed side by periodontal ligament (PDL) cells.
Ueda, Masae, Kuroishi, Kayoko N., Gunjigake, Kaori K., Ikeda, Erina, Kawamoto, Tatsuo   +4 more
openaire   +3 more sources

Mechanical load and SOST down-regulation cause increased bone formation. [PDF]

, 2019
(a) Double fluorescent ISH, showing SOST (red) and Col1a1 (green) in the spine and adjacent R of untrained (left) and trained (right) medaka (n = 3 for each group).
Shiri Kult (6288368), Elazar Zelzer (779419), Ron Shahar (217652), Yulia Shwartz (6288371), Shelley Griess-Fishheimer (6288377), Lior Ofer (6288365), Paul Zaslansky (126717), Janna Zaretsky (6288374), Mason N. Dean (3710599), Efrat Monsonego-Ornan (217656)   +9 more
core   +1 more source