Mechanical Properties of Bone Due to SOST Expression: A 3-Point Bending Assessment of Murine Femurs [PDF]
, 2012 Sclerostin, a protein coded for by the SOST gene, is an osteocyte-expressed negative regulator of bone formation. The absence of SOST in the genome may have an effect on bone formation both during skeletal maturation and full maturity.
Peterson, Kainoa John
core +2 more sources
PulmonologyBackground In COPD, the bronchial epithelium shows a pathologically activated Wnt pathway. Sclerostin (SOST) is a secreted glycoprotein that is associated with bone metabolism and blocks the Wnt pathway.
C.A. Amado +10 more
doaj +1 more source
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, Volume 13, Issue 28, 18 May 2026.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source
Behavioral and Neural Correlates of Cognitive Training and Transfer Effects in Stroke Patients
Frontiers in Neurology, 2020 Stroke lesions are frequently followed by cognitive impairments. Cognitive training is a non-pharmacological intervention that can promote neural compensation mechanisms and strategies to remediate cognitive impairments.
Eliane C. Miotto +8 more
doaj +1 more source
Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone [PDF]
, 2007 Sclerostin, the secreted protein product of the SOST gene, which is mainly expressed by osteocytes, has recently been proposed as a negative regulator of bone osteoblastogenesis.
LEOPIZZI, MARTINA +6 more
core +1 more source
Global Deletion of Sost Increases Intervertebral Disc Hydration But May Trigger Chondrogenesis [PDF]
, 2020 Indiana University-Purdue University Indianapolis (IUPUI)Intervertebral discs (IVD) degenerate earlier than many other musculoskeletal tissues and will continue to degenerate with aging.
Kroon, Tori
core +1 more source
Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression.
PLoS ONE, 2011 The Wnt signaling pathway is a robust regulator of skeletal homeostasis. Gain-of-function mutations promote high bone mass, whereas loss of Lrp5 or Lrp6 co-receptors decrease bone mass.
Damian C Genetos +2 more
doaj +1 more source
SOST expression in medaka vertebra and dorsal fin R. [PDF]
, 2019 (a–d) An NS of medaka vertebra and adjacent fin R. (a) HE-stained section. The blue and yellow squares mark 2 regions in the dorsal fin R, shown in (b) and (c), respectively. (b–c) ISH showing SOST expression in the cartilaginous core of the dorsal fin R
Shiri Kult (6288368) +9 more
core +1 more source
ESEM Analysis of Mice Femurs with Varying SOST Levels [PDF]
, 2012 This project’s goal was to analyze the properties of the cortical femur on 100 mice bones from Lawrence Livermore National Laboratory. Analysis was limited to imaging which determined the ratio of bone volume to total volume (BV/TV) and osteocyte lacunae
McClay, Patrick K.
core +1 more source
Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4 [PDF]
, 2011 Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods of dynamic strain and used quantitative reverse ...
Meakin, LB +25 more
core +1 more source