Results 91 to 100 of about 11,099 (162)

Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone

, 2013
The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone.
Agholme, Fredrik,, Aspenberg, Per,, Macias, Brandon R.,   +2 more
core   +1 more source

Mechanical load and SOST down-regulation cause increased bone formation.

, 2019
(a) Double fluorescent ISH, showing SOST (red) and Col1a1 (green) in the spine and adjacent R of untrained (left) and trained (right) medaka (n = 3 for each group).
Shiri Kult (6288368), Elazar Zelzer (779419), Ron Shahar (217652), Yulia Shwartz (6288371), Shelley Griess-Fishheimer (6288377), Lior Ofer (6288365), Paul Zaslansky (126717), Janna Zaretsky (6288374), Mason N. Dean (3710599), Efrat Monsonego-Ornan (217656)   +9 more
core   +1 more source

Novel Loss of Function Variant in SOST From Chinese Family Results in Sclerosteosis 1

Molecular Genetics & Genomic Medicine
Background SOST encodes a secreted glycoprotein that is similar in sequence to the differential screening‐selected gene aberrative in neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists.
Yufan Guo, Xintao Wu, Yuting Jin, Yu Gu, Yuting Lou, Pu Miao, Ye Wang, Bijun Zhang, Xueting Lin, Chudi Zhang, Jianhua Feng   +10 more
doaj   +1 more source

Evaluation of Biomarkers in Patients with Different Periodontal Statuses

Essentials of Dentistry
Background: The aim of this study was to compare the levels of salivary nuclear factor kappa-β receptor activator ligand (RANKL), osteoprotegerin (OPG), tumor necrosis factor alpha (TNF)-α, and sclerostin (SOST) in individuals with different periodontal ...
Fatma Uçan Yarkaç, Ümmühan Tekin Atay, Fatma Altıparmak   +2 more
doaj   +1 more source

A novel nonosteocytic regulatory mechanism of bone modeling.

PLoS Biology, 2019
Osteocytes, cells forming an elaborate network within the bones of most vertebrate taxa, are thought to be the master regulators of bone modeling, a process of coordinated, local bone-tissue deposition and removal that keeps bone strains at safe levels ...
Lior Ofer, Mason N Dean, Paul Zaslansky, Shiri Kult, Yulia Shwartz, Janna Zaretsky, Shelley Griess-Fishheimer, Efrat Monsonego-Ornan, Elazar Zelzer, Ron Shahar   +9 more
doaj   +1 more source

Global Deletion of Sost Increases Intervertebral Disc Hydration But May Trigger Chondrogenesis

, 2020
Indiana University-Purdue University Indianapolis (IUPUI)Intervertebral discs (IVD) degenerate earlier than many other musculoskeletal tissues and will continue to degenerate with aging.
Kroon, Tori
core   +1 more source

SOST expression in medaka vertebra and dorsal fin R.

, 2019
(a–d) An NS of medaka vertebra and adjacent fin R. (a) HE-stained section. The blue and yellow squares mark 2 regions in the dorsal fin R, shown in (b) and (c), respectively. (b–c) ISH showing SOST expression in the cartilaginous core of the dorsal fin R
Shiri Kult (6288368), Elazar Zelzer (779419), Ron Shahar (217652), Yulia Shwartz (6288371), Shelley Griess-Fishheimer (6288377), Lior Ofer (6288365), Paul Zaslansky (126717), Janna Zaretsky (6288374), Mason N. Dean (3710599), Efrat Monsonego-Ornan (217656)   +9 more
core   +1 more source

Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone

, 2007
Sclerostin, the secreted protein product of the SOST gene, which is mainly expressed by osteocytes, has recently been proposed as a negative regulator of bone osteoblastogenesis.
LEOPIZZI, MARTINA, Mariangela Sebastiani, DI VITO, MAURA, S. Berni, E. Bonucci, SILVESTRINI, GIULIANA, P. Ballanti   +6 more
core   +1 more source

Profiles of Wnt pathway gene expression during tooth morphogenesis

Frontiers in Physiology
Mouse and human genetic studies indicate key roles of the Wnt10a ligand in odontogenesis. Previous studies have identified effectors and regulators of the Wnt signaling pathway actively expressed during key stages of tooth morphogenesis.
Resmi Raju, Jeremie Oliver Piña, Jeremie Oliver Piña, Daniela M. Roth, Daniela M. Roth, Parna Chattaraj, Fahad K. Kidwai, Fabio R. Faucz, James Iben, Gus Fridell, Ryan K. Dale, Rena N. D’Souza   +11 more
doaj   +1 more source

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOST.

PLoS ONE
A haplotype block at the sclerostin (SOST) gene correlates with bone mineral density (BMD) and increased periodontitis risk in smokers. Investigating the putative causal variants within this block, our study aimed to elucidate the impact of linked ...
Avneesh Chopra, Jiahui Song, January Weiner Rd, Dieter Beule, Arne S Schaefer   +4 more
doaj   +1 more source