Results 101 to 110 of about 10,314 (209)

Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang

Diabetes, Metabolic Syndrome and Obesity, 2021
Jun Li,1,* YanXia Ren,1,* SiYuan Li,2 JiaJia Li3 1Endocrinology and Metabolism Department, First Affiliated Hosptital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Shihezi ...
Li J, Ren Y, Li S, Li J
doaj  

血清硬骨素在维生素D缺乏性佝偻病诊断中的检测意义

Zhongguo shiyan zhenduanxue, 2021
硬骨素(SOST)是一种主要由骨细胞分泌的蛋白质,其主要功能是抑制成骨细胞矿化,进而抑制骨形成[1]。维生素D缺乏性佝偻病患儿早期便会出现骨矿化不足。本研究拟通过分析患维生素D缺乏性佝偻病的婴幼儿血清SOST的水平变化,探讨SOST在佝偻病诊断中的意义。
李嘉, 刘晓燕, 彭慧云, 陈耀武
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Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin [PDF]

, 2016
Excess of glucocorticoids, either due to disease or iatrogenic, increases bone resorption and decreases bone formation and is a leading cause of osteoporosis and bone fractures worldwide. Improved therapeutic strategies are sorely needed. We investigated
Peacock, Munro, Lilian I Plotkin, Teresita Bellido, Plotkin, Lilian I., Amy Y Sato, Allen, Matthew R., Sato, Amy Y., Bellido, Teresita, Munro Peacock, Delgado-Calle, Jesus, Keith W Condon, Condon, Keith W., Meloney Cregor, Jesus Delgado-Calle, Matthew R Allen, Cregor, Meloney   +15 more
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Novel Loss of Function Variant in SOST From Chinese Family Results in Sclerosteosis 1

Molecular Genetics & Genomic Medicine
Background SOST encodes a secreted glycoprotein that is similar in sequence to the differential screening‐selected gene aberrative in neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists.
Yufan Guo, Xintao Wu, Yuting Jin, Yu Gu, Yuting Lou, Pu Miao, Ye Wang, Bijun Zhang, Xueting Lin, Chudi Zhang, Jianhua Feng   +10 more
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Evaluation of Biomarkers in Patients with Different Periodontal Statuses

Essentials of Dentistry
Background: The aim of this study was to compare the levels of salivary nuclear factor kappa-β receptor activator ligand (RANKL), osteoprotegerin (OPG), tumor necrosis factor alpha (TNF)-α, and sclerostin (SOST) in individuals with different periodontal ...
Fatma Uçan Yarkaç, Ümmühan Tekin Atay, Fatma Altıparmak   +2 more
doaj   +1 more source

An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling. [PDF]

Pathogenic variants disrupting the binding between sclerostin (encoded by SOST) and its receptor LRP4 have previously been described to cause sclerosteosis, a rare high bone mass disorder.
Schinke, Thorsten, Boudin, Eveline, Van Hul, Wim, Steenackers, Ellen, Kramer, Ina, Mateiu, Ligia, Yorgan, Timur A., Hendrickx, Gretl, Kneissel, Michaela, Mortier, Geert   +9 more
core   +3 more sources

A novel nonosteocytic regulatory mechanism of bone modeling.

PLoS Biology, 2019
Osteocytes, cells forming an elaborate network within the bones of most vertebrate taxa, are thought to be the master regulators of bone modeling, a process of coordinated, local bone-tissue deposition and removal that keeps bone strains at safe levels ...
Lior Ofer, Mason N Dean, Paul Zaslansky, Shiri Kult, Yulia Shwartz, Janna Zaretsky, Shelley Griess-Fishheimer, Efrat Monsonego-Ornan, Elazar Zelzer, Ron Shahar   +9 more
doaj   +1 more source

ESWT attenuates compressive stress-induced cartilaginous endplate degeneration via modulation of the SOST/Wnt/β-catenin signaling pathway

Frontiers in Bioengineering and Biotechnology
IntroductionCartilaginous endplate (CEP) degeneration is a critical contributor to intervertebral disc degeneration (IVDD) and is frequently induced by sustained compressive stress.
Pan Xiang, Pan Xiang, Junjun Hou, Junjun Hou, Chao Yang, Chao Yang, Ting Liang, Ting Liang, Wenbin Cai, Wenbin Cai, Fanlei Yang, Fanlei Yang, Jing Yang, Hao Xu, Hao Xu, Zongping Luo, Zongping Luo, Yanjun Che, Yanjun Che, Yanjun Che   +19 more
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Global Deletion of Sost Increases Intervertebral Disc Hydration but May Trigger Compensation [PDF]

, 2020
Intervertebral discs (IVD) degenerate earlier than many other musculoskeletal tissues and will continue to degenerate with aging. IVD degeneration affects up to 80 percent of the adult population and is a major contributing factor to low back pain.
Kroon, Tori
core  

Profiles of Wnt pathway gene expression during tooth morphogenesis

Frontiers in Physiology
Mouse and human genetic studies indicate key roles of the Wnt10a ligand in odontogenesis. Previous studies have identified effectors and regulators of the Wnt signaling pathway actively expressed during key stages of tooth morphogenesis.
Resmi Raju, Jeremie Oliver Piña, Jeremie Oliver Piña, Daniela M. Roth, Daniela M. Roth, Parna Chattaraj, Fahad K. Kidwai, Fabio R. Faucz, James Iben, Gus Fridell, Ryan K. Dale, Rena N. D’Souza   +11 more
doaj   +1 more source