Results 81 to 90 of about 11,099 (162)
Mechanical Properties of Bone Due to SOST Expression: Nanoindentation Assessment of Murine Femurs [PDF]
, 2013 In the human genome, the SOST gene codes for a protein sclerostin. Sclerostin is an osteocyte-expressed negative regulator of bone formation. When the SOST gene is not coded, bone formation is reduced in individuals during skeletal maturation. This study
Rafie, Amir
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, 2011 Sclerosteosis and Van Buchem disease are related recessive sclerosing bone dysplasias caused by alterations in the SOST gene. We tested the hypothesis that craniodiaphyseal dysplasia (CDD) (MIM 122860), an extremely rare sclerosing bone dysplasia ...
Ah-Ra Ko +33 more
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BMP Regulation of SOST and Osterix Expression During Embryonic Osteogenesis
, 2004 Sclerostin (SOST), a member of the cystine-knot superfamily, is essential for proper skeletogenesis since loss of function mutation in SOST gene results in sclerosteosis featured with massive bone growth in humans.
二藤 彰 +3 more
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SOST is a target gene for PTH in bone.
, 2005 Intermittent parathyroid hormone (PTH) application is an established pharmacological principle to stimulate bone formation. Yet, the molecular mechanisms underlying this bone anabolic action are not fully understood.
Kneissel, Michaela, Keller, Hansjoerg
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Diabetes, Metabolic Syndrome and Obesity, 2021 Jun Li,1,* YanXia Ren,1,* SiYuan Li,2 JiaJia Li3 1Endocrinology and Metabolism Department, First Affiliated Hosptital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Shihezi ...
Li J, Ren Y, Li S, Li J
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Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression.
PLoS ONE, 2011 The Wnt signaling pathway is a robust regulator of skeletal homeostasis. Gain-of-function mutations promote high bone mass, whereas loss of Lrp5 or Lrp6 co-receptors decrease bone mass.
Damian C Genetos +2 more
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ESEM Analysis of Mice Femurs with Varying SOST Levels [PDF]
, 2012 This project’s goal was to analyze the properties of the cortical femur on 100 mice bones from Lawrence Livermore National Laboratory. Analysis was limited to imaging which determined the ratio of bone volume to total volume (BV/TV) and osteocyte lacunae
McClay, Patrick K.
core
, 2013 sost mRNA levels normalized actb and rplp in control and L.rhamnosus treated fingerlings sampled 9,16and 23dpf. Error bars indicate mean ± S.D.
Oliana Carnevali (306579) +6 more
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Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4 [PDF]
, 2011 Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods of dynamic strain and used quantitative reverse ...
Meakin, LB +25 more
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Zhongguo shiyan zhenduanxue, 2021 硬骨素(SOST)是一种主要由骨细胞分泌的蛋白质,其主要功能是抑制成骨细胞矿化,进而抑制骨形成[1]。维生素D缺乏性佝偻病患儿早期便会出现骨矿化不足。本研究拟通过分析患维生素D缺乏性佝偻病的婴幼儿血清SOST的水平变化,探讨SOST在佝偻病诊断中的意义。
李嘉, 刘晓燕, 彭慧云, 陈耀武
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