Results 81 to 90 of about 10,314 (209)

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Effects of Zhuang Gu Zhi Tong Formula on Wnt/β-catenin Osteoporosis Pathway Antagonist SOST in Osteoporosis

Digital Chinese Medicine, 2019
Objective: To observe the effects of Zhuang Gu Zhi Tong Formula (ZGZTF) on antagonist SOST in canonical Wnt/β-catenin signaling pathway in osteoporosis.
Liu Xiang-Lin, Liu Le-Ping, He Rong, Zhang Shu-Qi, Zhao Zi-Yi, Peng Ting, Liu Hui-Ping, Zhang Guo-Min   +7 more
doaj   +1 more source

Compartment‐Specific Immune Remodeling of Renal Aging With C1q‐Associated Podocyte Activation

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Aging repatterns the renal immune response in a compartment‐specific manner, distinct from chronic kidney disease (CKD) adaptation. Glomerular aging features C1q‐associated podocyte activation and macrophage engagement, whereas tubulointerstitial aging is marked by B‐cell aggregation and tertiary lymphoid structure expansion.
Ju‐Young Moon, Kyuwon Shim, Hyun Ji Lim, Dae‐Kyu Kim, Young Yoon Moon, Su‐Woong Jung, Yang‐Gyun Kim, Hyuno Kang, Tae‐Hoon Lee, Jae‐Hyung Lee, Sang‐Ho Lee   +10 more
wiley   +1 more source

Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone [PDF]

, 2013
The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone.
Agholme, Fredrik,, Aspenberg, Per,, Macias, Brandon R.,   +2 more
core   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Inflammatory Neovascularization and Vascular Remodeling Associated With Carotid Plaque Destabilization

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A subset of endothelial cells in the AC region promoted neovascularization, while the PA region exhibited an increase in osteogenic VSMCs, contributing to vascular remodeling. Fibroblast‐mediated inflammatory regulation was predominantly enriched in the PA region, whereas the AC region harbored more macrophage subsets involved in lipid metabolism and ...
Xuejiao Dai, Jia Huang, Feihua Ni, Ruying Hu, Huiyan Zheng, Dan Wang, Jianqiao Zhang, Ting Sun   +7 more
wiley   +1 more source

Mechanical Properties of Bone Due to SOST Expression: Nanoindentation Assessment of Murine Femurs [PDF]

, 2013
In the human genome, the SOST gene codes for a protein sclerostin. Sclerostin is an osteocyte-expressed negative regulator of bone formation. When the SOST gene is not coded, bone formation is reduced in individuals during skeletal maturation. This study
Rafie, Amir
core   +2 more sources

Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao, Xiao‐li Dong, Rui‐ting Li, Qu‐huan Ma, Xiao‐feng Shi   +4 more
wiley   +1 more source

PO:03:035 | Biomarkers of Gut Epithelial Damage, Microbial Translocation, and Innate Immune Activation Characterize Patients with Axial Psoriatic Arthritis from Psoriasis Patients: Soluble Biomarker Analysis Insights from the ATTRACT Study

Reumatismo
Background. Increasing evidence suggests that axial spondyloarthritis (axSpA) may be associated with intestinal damage, leading to the translocation of bacterial products into the bloodstream and activation of the innate immune system.
Società Italiana di Reumatologia
doaj   +1 more source

The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Osteosarcopenia, defined as the coexistence of osteoporosis and sarcopenia, is an emerging geriatric syndrome linked to the musculoskeletal decline associated with aging. It is correlated with an increased risk of falls, fractures, disability, and mortality.
Javeria Taj, Rabia Zafar, Joshua Ekouo, Ayesha Junaid, Dujardin Makeda, Kinza Latif, Hermann Yokolo   +6 more
wiley   +1 more source