Results 61 to 70 of about 10,314 (209)
, 2013 sost mRNA levels normalized actb and rplp in control and L.rhamnosus treated fingerlings sampled 9,16and 23dpf. Error bars indicate mean ± S.D.
Oliana Carnevali (306579) +6 more
core +1 more source
Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw
Oral Diseases, EarlyView.ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park +5 more
wiley +1 more source
Frontiers in EndocrinologyObesity and Type 2 Diabetes Mellitus (T2DM) are intricate metabolic disorders with a multifactorial etiology, often leading to a spectrum of complications.
Tahani Alramah +20 more
doaj +1 more source
Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains
Nature Communications, 2020 The low-density lipoprotein receptor-related protein 6 (LRP6) is a co-receptor of the β-catenin-dependent Wnt signaling pathway and interacts with the Wnt inhibitor sclerostin (SOST). Here the authors present the crystal structure of SOST in complex with
Jinuk Kim +13 more
doaj +1 more source
Oral Diseases, EarlyView.ABSTRACT Objective To investigate the effects of sequential administration of romosozumab and denosumab on post‐extraction socket healing and osteonecrosis development in a murine tooth extraction model. Methods Forty female mice were randomly assigned to four groups: control (Ctrl), romosozumab (Rm), denosumab (Dmab), and sequential romosozumab ...
Seo‐Yeong An +3 more
wiley +1 more source
BMP Regulation of SOST and Osterix Expression During Embryonic Osteogenesis [PDF]
, 2004 Sclerostin (SOST), a member of the cystine-knot superfamily, is essential for proper skeletogenesis since loss of function mutation in SOST gene results in sclerosteosis featured with massive bone growth in humans.
二藤 彰 +3 more
core
Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner [PDF]
, 2013 WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emerging as key regulatory proteins with great promise as therapeutic agents for bone disorders.
Sebastian, Aimy +14 more
core +1 more source
Journal of Translational Medicine, 2023 Background Diabetes mellitus (DM) and periodontitis are two prevalent diseases with mutual influence. Accumulation of advanced glycation end products (AGEs) in hyperglycemia may impair cell function and worsen periodontal conditions. N 6-methyladenosine (
Jie Zhou +7 more
doaj +1 more source
A Novel Mutation in a Gene Causes Sclerosteosis in a Family of Mediterranean Origin
Medicina, 2022 Background and Objectives: Sclerostin is an SOST gene product that inhibits osteoblast activity and prevents excessive bone formation by antagonizing the Wnt signaling pathway. Sclerosteosis has been linked to loss of function mutations in the SOST gene.
Aishah A. Ekhzaimy +3 more
doaj +1 more source
Long‐term stability of conventional non‐regenerative periodontal treatment for furcation defects
Periodontology 2000, EarlyView.Abstract Background Furcation involvement (FI) in multi‐rooted teeth poses significant challenges in periodontal therapy due to complex anatomy and difficulty in achieving effective maintenance. FI is associated with increased periodontal destruction, especially in sites with narrow furcation entrances and deep root concavities.
Guo‐Hao Lin +6 more
wiley +1 more source