Results 61 to 70 of about 11,099 (162)

Longitudinal Proteomic Signatures of Dupilumab and Tralokinumab Treated Atopic Dermatitis Patients

Clinical and Translational Allergy, Volume 16, Issue 9, September 2026.
Although both dupilumab and tralokinumab effectively suppress core Th2 inflammation in atopic dermatitis, they exhibit divergent, treatment specific protein modulation. ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory disease driven by Type 2 (Th2) inflammation.
Wojciech Francuzik, Kristijan Pažur, Margitta Worm   +2 more
wiley   +1 more source

Plasma Sclerostin Levels in Rheumatoid Arthritis Women on TNF-α Inhibitor Therapy

Pharmaceuticals
Rheumatoid arthritis (RA) is associated with significant systemic and local bone loss. The aim of this study was to assess whether or not 15-month tumor necrosis factor α inhibitor (TNFαI) therapy in combination with methotrexate (MTX) affects ...
Anna Szeremeta, Agnieszka Jura-Półtorak, Aleksandra Zoń-Giebel, Krystyna Olczyk, Katarzyna Komosińska-Vassev   +4 more
doaj   +1 more source

Serum Bone‐, Muscle‐ and Fat‐ Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Aims This study aimed to explore the interactions among sclerostin, irisin and leptin, as well as their associations with body composition and bone metabolism in Chinese men with obesity. Materials and Methods This study included 26 men with normal weight and 78 men with obesity.
Xiang Chen, Sumin Shen, Mingxi Zou, Zhenlin Zhang, Nanwei Tong, Juan Li   +5 more
wiley   +1 more source

Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains

Nature Communications, 2020
The low-density lipoprotein receptor-related protein 6 (LRP6) is a co-receptor of the β-catenin-dependent Wnt signaling pathway and interacts with the Wnt inhibitor sclerostin (SOST). Here the authors present the crystal structure of SOST in complex with
Jinuk Kim, Wonhee Han, Taeyong Park, Eun Jin Kim, Injin Bang, Hyun Sik Lee, Yejing Jeong, Kyeonghwan Roh, Jeesoo Kim, Jong-Seo Kim, Chanhee Kang, Chaok Seok, Jin-Kwan Han, Hee-Jung Choi   +13 more
doaj   +1 more source

The Role of SIRT1 in Mediating Bone Marrow Edema and Its Interface With Bone Remodeling

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Bone marrow edema (BME), a common magnetic resonance imaging (MRI) finding characterized by increased fluid signal, is associated with pain and structural deterioration in conditions such as osteoarthritis and avascular necrosis. The pathophysiology of BME involves a complex interplay of vascular leakage, inflammation, microdamage ...
Yiming Chen, Xinyue Li, Zhongji Zheng, Zhihong Liu, Tao Xu, Yuanyi Tang   +5 more
wiley   +1 more source

Nitric oxide is involved in the down-regulation of sost expression induced by mechanical loading

, 2014
Mechanical stimulation reduces sclerostin expression in rodents. However, few data are available about the effect of physical stimuli in human systems. Recently we observed that the demethylating agent AzadC induces SOST expression in bone cells.
Riancho, J.A., Delgado-Calle, J., Klein-Nulend, J.   +2 more
core   +1 more source

Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression. [PDF]

, 2012
Emerging evidence has indicated a role of the bone morphoge-netic proteins (BMP) in the pathogenesis of certain cancers. Thesignaling of BMP family members is tightly regulated by theirantagonists, including noggin and SOST, which are, in turn, posi ...
Kwok-Wah, Chan, Zhang, Shu-Dong, Mohamed, El-Tanani, Glenn, Dickson, Yuen-Piu, Chan, Lok-Yee, Wong Michelle, McCrudden Cian, M., Gopesh, Srivastava, Claire, Grills, Ka-Kui, Chan, Yu-Han, Huang, Hiu-Fung, Yuen, Simon, Law, Fennell Dean, A.   +13 more
core   +2 more sources

The Health Benefits of Exercise: Molecular and Cellular Mechanisms

MedComm, Volume 7, Issue 9, September 2026.
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying, Huilin Wang, Xiu Lu, Wenjuan Zhang, Zhehao Lin, Kai Wang, Shangxuan Li, Lu Chen, Mingchao Jiang, Sarkawt Hamad, Yi Wang, Jianmin Wu, Shukuan Ling   +12 more
wiley   +1 more source

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner [PDF]

, 2013
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emerging as key regulatory proteins with great promise as therapeutic agents for bone disorders.
Sebastian, Aimy, Yee, Cristal S, Economides, Aris N, Harland, Richard M., Yee, Cristal S., Taher, Leila, Loots, Gabriela G., Collette, Nicole M, Murugesh, Deepa, Collette, Nicole M., Gale, Nicholas W., Economides, Aris N., Harland, Richard M, Gale, Nicholas W, Loots, Gabriela G   +14 more
core   +1 more source

Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study. [PDF]

PLoS ONE, 2018
Diabetes mellitus represents a major independent risk factor for developing fatal cardiovascular diseases (CVDs) presumably through accelerating atherosclerosis; the underlying cause of most CVDs.
Mona Kamal Saadeldin, Shereen Saeid Elshaer, Ibrahim Ali Emara, Mohamad Maged, Amal Kamal Abdel-Aziz   +4 more
doaj   +1 more source