Results 21 to 30 of about 13,466 (213)
In silico identification of sclerostin inhibitors
Molecular DiversityWnt/β-catenin signaling pathway plays a major role in the regulation of bone homeostasis. Sclerostin exhibits a high-affinity binding to the Wnt co-receptors LRP5/6 and therefore acts as an extracellular inhibitor of canonical Wnt signaling. Disruption of the interaction between LRP5/6 and sclerostin is essential for Wnt-related metabolic processes ...
Sepici Dinçel, Aylin +5 more
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Sclerostin is upregulated in the early stage of chondrogenic differentiation, but not required in endochondral ossification in vitro. [PDF]
PLoS ONE, 2018 Sclerostin is a potent inhibitor of the canonical Wnt signaling pathway. Wnt signaling pathways have multiple roles in the regulation of cartilage development, growth, and maintenance.
Yasuteru Yamaguchi +4 more
doaj +1 more source
eLife, 2021 The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost ...
Nicole R Gould +11 more
doaj +1 more source
Does oxidative status affect serum sclerostin levels in patients with type 2 diabetes mellitus? [PDF]
Folia Medica, 2023 Introduction: Sclerostin is a glycoprotein known as a negative regulator of bone formation, predominantly expressed by mature osteocytes.
Ilhan Sabancilar +4 more
doaj +3 more sources
Inhibitors of sclerostin [PDF]
Current Opinion in Rheumatology, 2014 Recent data suggest that inhibitors of sclerostin, an osteocyte-produced Wnt signaling pathway antagonist, can stimulate bone formation. This review provides rationale and summarizes recent evidence supporting this novel approach to skeletal anabolism.Data from numerous preclinical models in rodents and monkeys consistently demonstrate that ...
Matthew T, Drake, Joshua N, Farr
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Serum sclerostin levels in osteoporotic fracture patients [PDF]
, 2022 PURPOSE: Sclerostin inhibits bone formation and stimulates bone resorption. Previous studies found a positive association between bone density and serum sclerostin, but literature on sclerostin levels in osteoporotic fracture patients is scarce.
Krijnen, Pieta +9 more
core +1 more source
Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]
Open Biology, 2019 Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu +14 more
doaj +1 more source
Endocrine functions of sclerostin
Current Opinion in Endocrine and Metabolic Research, 2023 Sclerostin, the product of the SOST gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new bone formation.
openaire +2 more sources
Sclerostin regulation: a promising therapy for periodontitis by modulating alveolar bone
Chinese Medical Journal, 2020 . Periodontitis is one of the most prevalent epidemics affecting human health and life recently, and exploration of the pathogenesis and treatment of periodontitis has been valued by scholars.
Tian-Jiao Li +5 more
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Cardiovascular Diabetology, 2023 Background Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs).
Sheila González-Salvatierra +9 more
doaj +1 more source