Results 21 to 30 of about 13,851 (214)

In silico identification of sclerostin inhibitors

Molecular Diversity
Wnt/beta-catenin signaling pathway plays a major role in the regulation of bone homeostasis. Sclerostin exhibits a high-affinity binding to the Wnt co-receptors LRP5/6 and therefore acts as an extracellular inhibitor of canonical Wnt signaling ...
Dinçel, Aylin Sepici, Erkoç, Şakir, Dinçel, AYLİN, Ergünol, Erdal, Şimşek, Yusuf, Uludamar, Altay, Baran, Sahra Setenay   +6 more
core   +4 more sources

Serum sclerostin levels in osteoporotic fracture patients [PDF]

, 2022
PURPOSE: Sclerostin inhibits bone formation and stimulates bone resorption. Previous studies found a positive association between bone density and serum sclerostin, but literature on sclerostin levels in osteoporotic fracture patients is scarce.
Krijnen, Pieta, Schipper, Inger B., Appelman-Dijkstra, Natasha M., Reinders, C.R., Appelman-Dijkstra, N.M., Schipper, I.B., Reinders, Casper R., Gorter, E.A., Krijnen, P., Gorter, Erwin A., Inger B. Schipper, Natasha M. Appelman-Dijkstra, Erwin A. Gorter, Pieta Krijnen, Casper R. Reinders   +14 more
core   +1 more source

Does oxidative status affect serum sclerostin levels in patients with type 2 diabetes mellitus? [PDF]

Folia Medica, 2023
Introduction: Sclerostin is a glycoprotein known as a negative regulator of bone formation, predominantly expressed by mature  osteocytes.
Ilhan Sabancilar, Velid Unsal, Fidel Demir, Gulten Toprak, Zafer Pekkolay   +4 more
doaj   +3 more sources

Inhibitors of sclerostin [PDF]

Current Opinion in Rheumatology, 2014
Recent data suggest that inhibitors of sclerostin, an osteocyte-produced Wnt signaling pathway antagonist, can stimulate bone formation. This review provides rationale and summarizes recent evidence supporting this novel approach to skeletal anabolism.Data from numerous preclinical models in rodents and monkeys consistently demonstrate that ...
Matthew T, Drake, Joshua N, Farr
openaire   +2 more sources

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]

Open Biology, 2019
Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu, Zhenyu Wang, Jun Yang, Yongkui Wang, Kai Li, Bin Huang, Bo Yan, Ting Wang, Mangmang Li, Zhipeng Zou, Jian Yang, Guozhi Xiao, Zhong-Kai Cui, Anling Liu, Xiaochun Bai   +14 more
doaj   +1 more source

Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

eLife, 2021
The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost ...
Nicole R Gould, Katrina M Williams, Humberto C Joca, Olivia M Torre, James S Lyons, Jenna M Leser, Manasa P Srikanth, Marcus Hughes, Ramzi J Khairallah, Ricardo A Feldman, Christopher W Ward, Joseph P Stains   +11 more
doaj   +1 more source

Endocrine functions of sclerostin

Current Opinion in Endocrine and Metabolic Research, 2023
Sclerostin, the product of the SOST gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new bone formation.
openaire   +2 more sources

Sclerostin: From Molecule to Clinical Biomarker

, 2022
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling.
Diana Atanasova, Atanasova, Diana,, Filip Landgren, Magnusson, Per, Omran, Ahmed,, Per Magnusson, Omran, Ahmed, Landgren, Filip,, Magnusson, Per,, Atanasova, Diana, Landgren, Filip, Ahmed Omran   +11 more
core   +1 more source

Antitumor Effect of Sclerostin against Osteosarcoma [PDF]

, 2021
Various risk factors and causative genes of osteosarcoma have been reported in the literature; however, its etiology remains largely unknown. Bone formation is a shared phenomenon in all types of osteosarcomas, and sclerostin is an extracellular soluble ...
Kamanaka, Takayuki, Aoki, Kaoru, Takazawa, Akira, Akira Takazawa, Ideta, Hirokazu, Yoshida, Kazushige, Kito, Munehisa, Jun Sasaki, Hiroyuki Kato, Munehisa Kito, Takayuki Kamanaka, Haniu, Hisao, Yasuo Yoshimura, Takashi Takizawa, Atsushi Sobajima, Sobajima, Atsushi, Uemura, Takeshi, Hirokazu Ideta, Atsushi Tanaka, Saito, Naoto, Kato, Hiroyuki, Jun Takahashi, Naoto Saito, Okamoto, Masanori, Kazushige Yoshida, Shuichiro Suzuki, Yoshimura, Yasuo, Kaoru Aoki, Hisao Haniu, Suzuki, Shuichiro, Takeshi Uemura, Sasaki, Jun, Takahashi, Jun, Masanori Okamoto, Tanaka, Atsushi, Takizawa, Takashi   +35 more
core   +1 more source

Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures. [PDF]

Exp Physiol
Abstract Older adults experience a markedly increased risk of falls and fractures following hospital discharge, largely due to the rapid musculoskeletal deterioration associated with bed rest. Although age‐related muscle and bone loss typically develops gradually, acute physical inactivity accelerates key biological processes underlying sarcopenia and ...
Reyes JM, Hajj-Boutros G, Rouabhia D, Morais J, Salech F, Duque G.   +5 more
europepmc   +2 more sources