Results 21 to 30 of about 9,830 (184)

Endocrine functions of sclerostin

Current Opinion in Endocrine and Metabolic Research, 2023
Sclerostin, the product of the SOST gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new bone formation.
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Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells

Cardiovascular Diabetology, 2023
Background Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs).
Sheila González-Salvatierra, Cristina García-Fontana, Jesus Lacal, Francisco Andújar-Vera, Luis Martínez-Heredia, Raquel Sanabria-de la Torre, María Ferrer-Millán, Enrique Moratalla-Aranda, Manuel Muñoz-Torres, Beatriz García-Fontana   +9 more
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Assessment of sclerostin levels in the gingival crevicular fluid of patients with periodontitis: A clinico-biochemical crosssectional study [PDF]

Journal of Advanced Periodontology and Implant Dentistry, 2023
Background. Sclerostin, a glycoprotein, plays a key role in regulating bone mass. In this study, sclerostin levels in the gingival crevicular fluid (GCF) were assessed in patients with Stage III Grade C generalized periodontitis (SIII-GC) and Stage III ...
Nisha Ashifa, Krishnan Viswanathan, Sivapragasam Srinivasan, Senthil Kumar, Rajasekar Sundaram, Varsha K. Pavithran   +5 more
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Cardiovascular Safety and Sclerostin Inhibition

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Sclerostin, which is primarily produced by the osteocytes, inhibits the canonical Wnt pathway and thereby the osteoblasts and stimulates RANKL release by the osteocytes and thereby osteoclast recruitment. Inhibition of sclerostin therefore causes stimulation of bone formation and inhibition of resorption.
Bente Lomholt Langdahl, Lorenz Christian Hofbauer, John Colin Forfar   +2 more
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Association of sclerostin with cardiovascular events and mortality in dialysis patients

Renal Failure, 2020
Introduction Sclerostin has been reported to be a novel biomarker associated with the bone-vascular axis. In this study, we determined the relationships between serum sclerostin and all-cause mortality, the prevalence of cardiovascular events (CVEs), and
Yun Zou, Min Yang, Jiao Wang, Li Cui, Zhenxing Jiang, Jiule Ding, Min Li, Hua Zhou   +7 more
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Sclerostin is a promising therapeutic target for oral inflammation and regenerative dentistry

Journal of Translational Medicine, 2022
Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporosis.
Chufang Liao, Shanshan Liang, Yining Wang, Ting Zhong, Xiangning Liu   +4 more
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Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk

Biomedicines, 2021
Bone and muscle have been recognized as endocrine organs since they produce and secrete “hormone-like factors” that can mutually influence each other and other tissues, giving rise to a “bone–muscle crosstalk”.
Maria Sara Magarò, Jessika Bertacchini, Francesca Florio, Manuela Zavatti, Francesco Potì, Francesco Cavani, Emanuela Amore, Ilaria De Santis, Alessandro Bevilacqua, Luca Reggiani Bonetti, Pietro Torricelli, Delphine B. Maurel, Stefano Biressi, Carla Palumbo   +13 more
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Sclerostin–erbB-3 interactions: Modulation of erbB-3 activity by sclerostin [PDF]

Biochemical and Biophysical Research Communications, 2010
To gain insights into the mechanism of action of sclerostin, a protein that regulates bone mass, we performed yeast two-hybrid analyses using human SOST (sclerostin) cDNA cloned into pGBKT7 DNA-binding domain vector as a bait, and a normalized, high-complexity, universal cDNA library in a GAL4 activating domain vector.
Theodore A, Craig, Rajiv, Kumar
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The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6 [PDF]

Open Biology, 2016
The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts its function by interacting with the Wnt co-receptor LRP5/6, blocks the binding of Wnt factors and thereby inhibits Wnt signalling.
V. Boschert, C. Frisch, J. W. Back, K. van Pee, S. E. Weidauer, E.-M. Muth, P. Schmieder, M. Beerbaum, A. Knappik, P. Timmerman, T. D. Mueller   +10 more
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Novel actions of sclerostin on bone [PDF]

Journal of Molecular Endocrinology, 2019
The discovery that two rare autosomal recessive high bone mass conditions were caused by the loss of sclerostin expression prompted studies into its role in bone homeostasis. In this article, we aim to bring together the wealth of information relating to sclerostin in bone though discussion of rare human disorders in which sclerostin is reduced or ...
Gill, Holdsworth, Scott J, Roberts, Hua Zhu, Ke   +2 more
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