Results 21 to 30 of about 11,659 (170)

Novel actions of sclerostin on bone [PDF]

Journal of Molecular Endocrinology, 2019
The discovery that two rare autosomal recessive high bone mass conditions were caused by the loss of sclerostin expression prompted studies into its role in bone homeostasis. In this article, we aim to bring together the wealth of information relating to sclerostin in bone though discussion of rare human disorders in which sclerostin is reduced or ...
Gill, Holdsworth, Scott J, Roberts, Hua Zhu, Ke   +2 more
openaire   +2 more sources

Sclerostin promotes human dental pulp cells senescence [PDF]

, 2018
Background Senescence-related impairment of proliferation and differentiation limits the use of dental pulp cells for tissue regeneration. Deletion of sclerostin improves the dentinogenesis regeneration, while its role in dental pulp senescence is ...
Yi Zhou, Shanshan Liang, Yanjing Ou, Yining Wang   +3 more
core   +1 more source

Sclerostin expression in skeletal sarcomas [PDF]

Human Pathology, 2016
Sclerostin (SOST) is an extracellular Wnt signaling antagonist which negatively regulates bone mass. Despite this, the expression and function of SOST in skeletal tumors remain poorly described. Here, we first describe the immunohistochemical staining pattern of SOST across benign and malignant skeletal tumors with bone or cartilage matrix (n=68 ...
Shen, Jia, Meyers, Carolyn A, Shrestha, Swati, Singh, Arun, LaChaud, Greg, Nguyen, Vi, Asatrian, Greg, Federman, Noah, Bernthal, Nicholas, Eilber, Fritz C, Dry, Sarah M, Ting, Kang, Soo, Chia, James, Aaron W   +13 more
openaire   +4 more sources

Serum sclerostin levels in osteoporotic fracture patients

, 2022
PURPOSE: Sclerostin inhibits bone formation and stimulates bone resorption. Previous studies found a positive association between bone density and serum sclerostin, but literature on sclerostin levels in osteoporotic fracture patients is scarce.
Krijnen, Pieta, Schipper, Inger B., Appelman-Dijkstra, Natasha M., Reinders, C.R., Appelman-Dijkstra, N.M., Schipper, I.B., Reinders, Casper R., Gorter, E.A., Krijnen, P., Gorter, Erwin A.   +9 more
core   +1 more source

Antitumor Effect of Sclerostin against Osteosarcoma [PDF]

, 2021
Various risk factors and causative genes of osteosarcoma have been reported in the literature; however, its etiology remains largely unknown. Bone formation is a shared phenomenon in all types of osteosarcomas, and sclerostin is an extracellular soluble ...
Kamanaka, Takayuki, Aoki, Kaoru, Takazawa, Akira, Akira Takazawa, Ideta, Hirokazu, Yoshida, Kazushige, Kito, Munehisa, Jun Sasaki, Hiroyuki Kato, Munehisa Kito, Takayuki Kamanaka, Haniu, Hisao, Yasuo Yoshimura, Takashi Takizawa, Atsushi Sobajima, Sobajima, Atsushi, Uemura, Takeshi, Hirokazu Ideta, Atsushi Tanaka, Saito, Naoto, Kato, Hiroyuki, Jun Takahashi, Naoto Saito, Okamoto, Masanori, Kazushige Yoshida, Shuichiro Suzuki, Yoshimura, Yasuo, Kaoru Aoki, Hisao Haniu, Suzuki, Shuichiro, Takeshi Uemura, Sasaki, Jun, Takahashi, Jun, Masanori Okamoto, Tanaka, Atsushi, Takizawa, Takashi   +35 more
core   +1 more source

B4GALNT3 regulates glycosylation of sclerostin and bone massResearch in context [PDF]

, 2023
Summary: Background: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene is ...
Tobias, J. H., Tobias, Jon H., Ohlsson, Claes,, Movérare-Skrtic, Sofia, Karin Horkeby, Antti Koskela, Koskela, Antti, Wu, Jianyao,, Lerner, Ulf H., Alesutan, I., Li, Lei,, Nilsson, Karin H.,, Lerner, Ulf H,, Juha Tuukkanen, Marie K. Lagerquist, Horkeby, Karin L,, Tuukkanen, Juha, Voelkl, J., Luong, T. T. D., Maria Nethander, Henning, Petra,, Trang Thi Doan Luong, Ulf H. Lerner, Voelkl, Jakob, Alesutan, Ioana, Wu, Jianyao, Jon H. Tobias, Ioana Alesutan, Lei Li, Henning, Petra, Nethander, Maria,, Horkeby, Karin, Lagerquist, Marie K,, Luong, Trang Thi Doan, Jianyao Wu, Sofia Movérare-Skrtic, Lagerquist, Marie K., Karin H. Nilsson, Claes Ohlsson, Ohlsson, Claes, Nethander, Maria, Jakob Voelkl, Nilsson, Karin H., Li, Lei, Petra Henning, Tuukkanen, J., Moverare-Skrtic, Sofia,, Koskela, A.   +47 more
core   +1 more source

Sclerostin as a novel marker of bone turnover in athletes

, 2016
Sclerostin is a protein secreted by osteocytes that acts as an inhibitor of bone formation. It has been shown that physical activity affects sclerostin concentration and thus bone remodelling.
M Majda, M Słowińska-Lisowska, P Jóźków, M Mędraś, A Zagrodna   +4 more
core   +1 more source

The Role of Sclerostin in Bone and Ectopic Calcification [PDF]

International Journal of Molecular Sciences, 2020
Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased in the elderly and in patients with chronic kidney ...
Annelies De Maré, Patrick C. D’Haese, Anja Verhulst   +2 more
openaire   +3 more sources

The sclerostin-bone protein interactome [PDF]

Biochemical and Biophysical Research Communications, 2012
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP ...
Hemamalini, Devarajan-Ketha, Theodore A, Craig, Benjamin J, Madden, H, Robert Bergen, Rajiv, Kumar   +4 more
openaire   +2 more sources

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source