Sclerostin regulation: a promising therapy for periodontitis by modulating alveolar bone
Chinese Medical Journal, 2020 . Periodontitis is one of the most prevalent epidemics affecting human health and life recently, and exploration of the pathogenesis and treatment of periodontitis has been valued by scholars.
Tian-Jiao Li +5 more
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SCLEROSTIN IMMUNOREACTIVITY INCREASES WITHIN THE CORTICAL BONE OSTEOCYTES IN THE FEMUR OF AGING MICE
, 2016 Sclerostin, a secreted glycoprotein, is known to down-regulate osteocyte differentiation from osteoblasts and acts as a negative modulator of bone formation.
ABU HAMDAN, NATALIE
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Association of sclerostin with cardiovascular events and mortality in dialysis patients
Renal Failure, 2020 Introduction Sclerostin has been reported to be a novel biomarker associated with the bone-vascular axis. In this study, we determined the relationships between serum sclerostin and all-cause mortality, the prevalence of cardiovascular events (CVEs), and
Yun Zou +7 more
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Cardiovascular Diabetology, 2023 Background Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs).
Sheila González-Salvatierra +9 more
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Assessment of sclerostin levels in the gingival crevicular fluid of patients with periodontitis: A clinico-biochemical crosssectional study [PDF]
Journal of Advanced Periodontology and Implant Dentistry, 2023 Background. Sclerostin, a glycoprotein, plays a key role in regulating bone mass. In this study, sclerostin levels in the gingival crevicular fluid (GCF) were assessed in patients with Stage III Grade C generalized periodontitis (SIII-GC) and Stage III ...
Nisha Ashifa +5 more
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Sclerostin–erbB-3 interactions: Modulation of erbB-3 activity by sclerostin [PDF]
Biochemical and Biophysical Research Communications, 2010 To gain insights into the mechanism of action of sclerostin, a protein that regulates bone mass, we performed yeast two-hybrid analyses using human SOST (sclerostin) cDNA cloned into pGBKT7 DNA-binding domain vector as a bait, and a normalized, high-complexity, universal cDNA library in a GAL4 activating domain vector.
Theodore A, Craig, Rajiv, Kumar
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Cardiovascular Safety and Sclerostin Inhibition
The Journal of Clinical Endocrinology & Metabolism, 2021 Abstract Sclerostin, which is primarily produced by the osteocytes, inhibits the canonical Wnt pathway and thereby the osteoblasts and stimulates RANKL release by the osteocytes and thereby osteoclast recruitment. Inhibition of sclerostin therefore causes stimulation of bone formation and inhibition of resorption.
Bente Lomholt Langdahl +2 more
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Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk
Biomedicines, 2021 Bone and muscle have been recognized as endocrine organs since they produce and secrete “hormone-like factors” that can mutually influence each other and other tissues, giving rise to a “bone–muscle crosstalk”.
Maria Sara Magarò +13 more
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Sclerostin is a promising therapeutic target for oral inflammation and regenerative dentistry
Journal of Translational Medicine, 2022 Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporosis.
Chufang Liao +4 more
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Sclerostin Inhibition in the Management of Osteoporosis [PDF]
Calcified Tissue International, 2016 The recognition of the importance of the Wnt-signaling pathway in bone metabolism and studies of patients with rare skeletal disorders characterized by high bone mass identified sclerostin as target for the development of new therapeutics for osteoporosis.
Natasha M. Appelman-Dijkstra +1 more
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