Biomarkers of response to therapy in Ankylosing Spondylitis [PDF]
, 2013 Ankylosing Spondylitis (AS) is a chronic inflammatory disorder of the spine which leads to progressive spinal fusion and deformity. With improvements in MRI, this condition is now being recognized earlier.
Pathan, Ejaz Mohammed Ishaq
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Association of sclerostin with cardiovascular events and mortality in dialysis patients
Renal Failure, 2020 Introduction Sclerostin has been reported to be a novel biomarker associated with the bone-vascular axis. In this study, we determined the relationships between serum sclerostin and all-cause mortality, the prevalence of cardiovascular events (CVEs), and
Yun Zou +7 more
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Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk
Biomedicines, 2021 Bone and muscle have been recognized as endocrine organs since they produce and secrete “hormone-like factors” that can mutually influence each other and other tissues, giving rise to a “bone–muscle crosstalk”.
Maria Sara Magarò +13 more
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Sclerostin–erbB-3 interactions: Modulation of erbB-3 activity by sclerostin [PDF]
Biochemical and Biophysical Research Communications, 2010 To gain insights into the mechanism of action of sclerostin, a protein that regulates bone mass, we performed yeast two-hybrid analyses using human SOST (sclerostin) cDNA cloned into pGBKT7 DNA-binding domain vector as a bait, and a normalized, high-complexity, universal cDNA library in a GAL4 activating domain vector.
Theodore A, Craig, Rajiv, Kumar
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Cardiovascular Safety and Sclerostin Inhibition
The Journal of Clinical Endocrinology & Metabolism, 2021 Abstract Sclerostin, which is primarily produced by the osteocytes, inhibits the canonical Wnt pathway and thereby the osteoblasts and stimulates RANKL release by the osteocytes and thereby osteoclast recruitment. Inhibition of sclerostin therefore causes stimulation of bone formation and inhibition of resorption.
Bente Lomholt Langdahl +2 more
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The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6 [PDF]
Open Biology, 2016 The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts its function by interacting with the Wnt co-receptor LRP5/6, blocks the binding of Wnt factors and thereby inhibits Wnt signalling.
V. Boschert +10 more
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Assessment of sclerostin levels in the gingival crevicular fluid of patients with periodontitis: A clinico-biochemical crosssectional study [PDF]
Journal of Advanced Periodontology and Implant Dentistry, 2023 Background. Sclerostin, a glycoprotein, plays a key role in regulating bone mass. In this study, sclerostin levels in the gingival crevicular fluid (GCF) were assessed in patients with Stage III Grade C generalized periodontitis (SIII-GC) and Stage III ...
Nisha Ashifa +5 more
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Sclerostin is a promising therapeutic target for oral inflammation and regenerative dentistry
Journal of Translational Medicine, 2022 Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporosis.
Chufang Liao +4 more
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Sclerostin Inhibition in the Management of Osteoporosis [PDF]
Calcified Tissue International, 2016 The recognition of the importance of the Wnt-signaling pathway in bone metabolism and studies of patients with rare skeletal disorders characterized by high bone mass identified sclerostin as target for the development of new therapeutics for osteoporosis.
Natasha M. Appelman-Dijkstra +1 more
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Antitumor Effect of Sclerostin against Osteosarcoma [PDF]
, 2021 Various risk factors and causative genes of osteosarcoma have been reported in the literature; however, its etiology remains largely unknown. Bone formation is a shared phenomenon in all types of osteosarcomas, and sclerostin is an extracellular soluble ...
Kamanaka, Takayuki +35 more
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