Results 51 to 60 of about 13,466 (213)
Sclerostin expression in skeletal sarcomas [PDF]
Human Pathology, 2016 Sclerostin (SOST) is an extracellular Wnt signaling antagonist which negatively regulates bone mass. Despite this, the expression and function of SOST in skeletal tumors remain poorly described. Here, we first describe the immunohistochemical staining pattern of SOST across benign and malignant skeletal tumors with bone or cartilage matrix (n=68 ...
Shen, Jia +13 more
openaire +4 more sources
The Effects of Sclerostin on the Immune System [PDF]
Current Osteoporosis Reports, 2020 We reviewed recent progress on the role of sclerostin (SOST) and its effects on the immune system in order to summarize the current state of knowledge in osteoimmunology, in regard to hematopoiesis, lymphopoiesis, and inflammation.Changes in sclerostin levels affect distinct niches within the bone marrow that support hematopoietic stem cells and B cell
Cristine Donham, Jennifer O. Manilay
openaire +4 more sources
Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men [PDF]
, 2013 Objectives: Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people.
Heer, M. +4 more
core
Sclerostin: From Molecule to Clinical Biomarker
, 2022 Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling.
Diana Atanasova +11 more
core +1 more source
Kidney & Blood Pressure Research, 2018 Background/Aims: Potential relationships between serum sclerostin levels and the levels of bone metabolic markers in maintenance hemodialysis (MHD) patients have yet to be evaluated.
Madoka Sato +4 more
doaj +1 more source
Advanced Science, EarlyView.In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma +10 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore +5 more
wiley +1 more source
Overview of investigated Sclerostin variants.
, 2013 (A) Surface and secondary structure representation of Sclerostin with residues selected for single point mutations shown as spheres. Residues located in the flexible loop of Sclerostin are colored green, amino acid residues in finger 1 and 2 are ...
Katharina van Pee (491264) +6 more
core +1 more source
The Anatomical Record, EarlyView.Abstract Cortical bone expansion is an age‐related process where, through endosteal resorption and periosteal apposition, cross‐sectional diameter increases while cortical thickness decreases in long bone diaphyses. Local variation has been observed in this process between cross‐sectional locations, but few studies have examined directional variation ...
Gregory J. Wehrman +4 more
wiley +1 more source
How accurate is your sclerostin measurement? Comparison between three commercially available sclerostin ELISA kits [PDF]
, 2016 Sclerostin, bone formation antagonist is in the spotlight as a potential biomarker for diseases presenting with associated bone disorders such as chronic kidney disease (CDK-MBD). Accurate measurement of sclerostin is therefore important.
Fisher, Emily +13 more
core +2 more sources