Results 51 to 60 of about 13,851 (214)
The Anatomical Record, EarlyView.Abstract Cortical bone expansion is an age‐related process where, through endosteal resorption and periosteal apposition, cross‐sectional diameter increases while cortical thickness decreases in long bone diaphyses. Local variation has been observed in this process between cross‐sectional locations, but few studies have examined directional variation ...
Gregory J. Wehrman +4 more
wiley +1 more source
Decreased Sclerostin Secretion in Humans and Mice With Nonalcoholic Fatty Liver Disease
Frontiers in Endocrinology, 2021 ObjectivesGrowing evidence argues for a relationship between liver and bone metabolisms. Sclerostin is a secreted glycoprotein and could antagonize osteoblast-mediated bone formation.
Fangli Zhou +7 more
doaj +1 more source
Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men [PDF]
, 2013 Objectives: Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people.
Heer, M. +4 more
core
Sclerostin expression in skeletal sarcomas [PDF]
Human Pathology, 2016 Sclerostin (SOST) is an extracellular Wnt signaling antagonist which negatively regulates bone mass. Despite this, the expression and function of SOST in skeletal tumors remain poorly described. Here, we first describe the immunohistochemical staining pattern of SOST across benign and malignant skeletal tumors with bone or cartilage matrix (n=68 ...
Shen, Jia +13 more
openaire +4 more sources
The Effects of Sclerostin on the Immune System [PDF]
Current Osteoporosis Reports, 2020 We reviewed recent progress on the role of sclerostin (SOST) and its effects on the immune system in order to summarize the current state of knowledge in osteoimmunology, in regard to hematopoiesis, lymphopoiesis, and inflammation.Changes in sclerostin levels affect distinct niches within the bone marrow that support hematopoietic stem cells and B cell
Cristine Donham, Jennifer O. Manilay
openaire +4 more sources
Kidney & Blood Pressure Research, 2018 Background/Aims: Potential relationships between serum sclerostin levels and the levels of bone metabolic markers in maintenance hemodialysis (MHD) patients have yet to be evaluated.
Madoka Sato +4 more
doaj +1 more source
BMEMat, EarlyView.This study reports a novel Zr58Cu25Al14Nb3 bulk metallic glass that possesses high mechanical strength and low elastic modulus, which further promotes efficient mechanotransduction and significantly improves peri‐implant bone quality upon cyclic occlusal loading.
Yunshu Wu +10 more
wiley +1 more source
Sclerostin and chronic kidney disease
, 2017 Chronic kidney disease (CKD) leads to the development of mineral and skeletal disturbances. They increase the risk of fractures, cardiovascular complications and, in consequence, decrease patients’ lifespan.
Beata Naumnik +3 more
core +1 more source
Progress in bone tissue engineering biomaterials: Development, challenges, and prospects
VIEW, EarlyView.Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang +7 more
wiley +1 more source
Bone Health and Aging in Klinefelter Syndrome
Andrology, EarlyView.ABSTRACT Klinefelter syndrome (KS) is typically diagnosed in young adults, but advances in prenatal testing have led to its recognition at a much earlier age. Conversely, diagnosis in late adulthood remains uncommon, but still occurs. Independently from the age at diagnosis, KS individuals now receive more accurate and tailored care management than in ...
Filippo Vignali +4 more
wiley +1 more source