Results 71 to 80 of about 13,851 (214)
Kidney & Blood Pressure Research, 2015 Background/Aims: Cardiovascular calcification contributes to the increased mortality in hemodialysis patients. Sclerostin was identified as an antianabolic bone factor causing soft tissue calcification. Data on prospective large-scale studies associating
Albina Nowak +6 more
doaj +1 more source
Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship
Journal of Periodontal Research, EarlyView.This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw +4 more
wiley +1 more source
Positive and Negative Regulators of Sclerostin Expression
, 2022 Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation.
Rina Iwamoto +7 more
core +1 more source
BMC Nephrology, 2019 Background Sclerostin, an antagonist of the Wingless-type mouse mammary tumor virus integration site (Wnt) pathway that regulates bone metabolism, is a potential contributor of chronic kidney disease (CKD)–mineral and bone disorder (MBD), which has ...
Te-Hui Kuo +7 more
doaj +1 more source
Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw
Oral Diseases, EarlyView.ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park +5 more
wiley +1 more source
Load-sensitive Sclerostin regulation requires TGFβ signaling.
, 2013 Immunohistochemistry shows reduced Sclerostin expression between the loaded and nonloaded tibiae of WT mice, but no difference in Sclerostin expression in tibiae of DNTβRII mice (A).
Tamara Alliston (265049) +3 more
core +1 more source
International Journal of Endocrinology, 2014 Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis.
Theerawut Klangjareonchai +7 more
doaj +1 more source
Oral Diseases, EarlyView.ABSTRACT Objective Head and neck cancer radiotherapy can lead to jaw osteoradionecrosis (ORN). There is currently no definitive treatment for ORN. The efficacy of a novel orally delivered aglycosylated IGF‐1 with an E‐peptide (CTB‐Pro‐IGF‐1), bioencapsulated in plant cells, was evaluated as therapy for jaw ORN in rats. Materials and Methods Rat jaw ORN
Sunday O. Akintoye +5 more
wiley +1 more source
Inflammation and mechanical force‐induced bone remodeling
Periodontology 2000, EarlyView.Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
Serum sclerostin and sympathetic skin response: relationship with myeloma bone disease
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022 Background Myeloma bone disease (MBD) is a common complication that significantly contributes to morbidity and mortality in multiple myeloma (MM). Serum sclerostin level and sympathetic activity can affect MBD.
Alaa A. Omran +4 more
doaj +1 more source