Results 81 to 90 of about 13,851 (214)

The Effect of Renal Dysfunction on Circulating Sclerostin Level in Patients with Type 2 Diabetes

International Journal of Endocrinology, 2014
Objective. Sclerostin is a Wnt inhibitor produced specifically by osteocytes. However, it is not currently clear whether renal dysfunction has an effect on circulating sclerostin level in patients with type 2 diabetes.
Se Hwa Kim, Soo Young Yoon, Sung-Kil Lim, Yumie Rhee   +3 more
doaj   +1 more source

Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly

Periodontology 2000, EarlyView.
Abstract Objectives This review synthesizes evidence regarding the prevalence, epidemiological associations, and mechanistic pathways between osteoporosis, periodontal disease, and dental implant therapy. Materials and Methods A literature review was conducted to identify studies focused on: osteoporosis, periodontal disease, and dental implants ...
Samin Sirous, Jaclyn C. Chalmers, Pin‐Ying Li, Yumna Subhani, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

The sclerostin-bone protein interactome [PDF]

Biochemical and Biophysical Research Communications, 2012
The secreted glycoprotein, sclerostin alters bone formation. To gain insights into the mechanism of action of sclerostin, we examined the interactions of sclerostin with bone proteins using a sclerostin affinity capture technique. Proteins from decalcified rat bone were captured on a sclerostin-maltose binding protein (MBP) amylose column, or on a MBP ...
Hemamalini, Devarajan-Ketha, Theodore A, Craig, Benjamin J, Madden, H, Robert Bergen, Rajiv, Kumar   +4 more
openaire   +2 more sources

Romosozumab for the treatment of osteoporosis

Osteoporosis and Sarcopenia, 2018
Romosozumab, a specific inhibitor of sclerostin, is a unique approach to therapy for postmenopausal osteoporosis and related disorders. The elucidation of sclerostin deficiency as the molecular defect of syndromes of high bone mass with normal quality ...
Michael R. McClung
doaj   +1 more source

Decoding host–microbial dynamics in peri‐implantitis: Ecosystem‐specific experimental models

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is an inflammatory disease arising within a unique host–microbial–biomaterial ecosystem. Unlike periodontitis, peri‐implant tissues lack a periodontal ligament and epithelial junction integrity and interface with metal oxides on titanium surfaces.
Georgios A. Kotsakis, Davi Araújo, Asaf Wilensky, Juliana Girón Bastidas, Stella Alimperti, Flavia Pirih   +5 more
wiley   +1 more source

Sclerostin stimulates angiogenesis in human endothelial cells

, 2017
Sclerostin, negative regulator of bone formation, has been originally known as an osteocyte product. Recently, it has been also detected in hypertrophic chondrocytes, distinctive cells of avascular cartilage which is invaded by capillaries and then ...
Angela Notarnicola, Giacomina Brunetti, Roberto Tamma, ORANGER, ANGELA, LIPPO, LUCIANA, Silvia Colucci, Domenico Ribatti, Zerlotin, Roberta, RIBATTI, Domenico, COLAIANNI, GRAZIANA, NOTARNICOLA, ANGELA, Maria Grano, GRANO, Maria, Roberta Zerlotin, MORI, GIORGIO, Angela Oranger, Pignataro, Paolo, Nunzio Cirulli, CARBONE, CLAUDIA, TAMMA, ROBERTO, Giorgio Mori, Claudia Carbone, Colucci, Silvia, Biagio Moretti, Luciana Lippo, Paolo Pignataro, MORETTI, Biagio, BRUNETTI, GIACOMINA, Cirulli, Nunzio, Graziana Colaianni, COLUCCI, Silvia Concetta   +30 more
core   +1 more source

Antiresorptive therapy influence on peri‐implant diseases: Clinical implications and osteoimmunological perspectives

Periodontology 2000, EarlyView.
Abstract Background/Aim Antiresorptive therapy represents a cornerstone in the management of osteoporosis and cancer‐related bone disease through suppression of osteoclast‐mediated bone resorption. As implant therapy becomes more common in aging populations, clinicians increasingly encounter patients receiving these medications, thus making their ...
Emilio A. Cafferata, Frank Schwarz, Reinhard Gruber   +2 more
wiley   +1 more source

Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments [PDF]

Bone, 2018
Sclerostin is a 190 amino acid protein secreted primarily by osteocytes. It was initially identified due to mutations in the SOST gene associated with high bone mass phenotypes. Much recent work has sought to determine the importance of sclerostin across an array of conditions which affect the human skeleton. However, accurate measurement of sclerostin
Matthew T, Drake, Jennifer S, Fenske, Frank A, Blocki, Claudia, Zierold, Natasha, Appelman-Dijkstra, Socrates, Papapoulos, Sundeep, Khosla   +6 more
openaire   +2 more sources

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, Volume 309, Issue 11, Page 3375-3396, November 2026.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source