Results 81 to 90 of about 13,466 (213)

Positive and Negative Regulators of Sclerostin Expression

, 2022
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation.
Rina Iwamoto, Nobuyuki Udagawa, Kobayashi, Yasuhiro, Iwamoto, Rina, Udagawa, Nobuyuki, Yasuhiro Kobayashi, Koide, Masanori, Masanori Koide   +7 more
core   +1 more source

Oral Delivery of Bioencapsulated CTB‐Pro‐IGF‐1 Enhances Bone Regeneration in a Pre‐Clinical Rat Model of Jaw Osteoradionecrosis

Oral Diseases, EarlyView.
ABSTRACT Objective Head and neck cancer radiotherapy can lead to jaw osteoradionecrosis (ORN). There is currently no definitive treatment for ORN. The efficacy of a novel orally delivered aglycosylated IGF‐1 with an E‐peptide (CTB‐Pro‐IGF‐1), bioencapsulated in plant cells, was evaluated as therapy for jaw ORN in rats. Materials and Methods Rat jaw ORN
Sunday O. Akintoye, Arularasan Anbinselvam, Prasath Jeyaraman, Uddhab Karki, Geetanjali Wakade, Henry Daniell   +5 more
wiley   +1 more source

Sequential Anabolic and Antiresorptive Treatment Promotes Medication‐Related Osteonecrosis of the Jaw in Mice

Oral Diseases, EarlyView.
ABSTRACT Objective To investigate the effects of sequential administration of romosozumab and denosumab on post‐extraction socket healing and osteonecrosis development in a murine tooth extraction model. Methods Forty female mice were randomly assigned to four groups: control (Ctrl), romosozumab (Rm), denosumab (Dmab), and sequential romosozumab ...
Seo‐Yeong An, Hae‐Seo Park, Reuben H. Kim, Moon‐Young Kim   +3 more
wiley   +1 more source

Chinese Guideline on Risk Management of Osteoporosis in the General Public

Orthopaedic Surgery, EarlyView.
Summary of the background, key recommendations, and expected impact of the public guideline for osteoporosis risk management. ABSTRACT Background Osteoporosis is a common chronic skeletal disorder characterized by decreased bone mass and microarchitectural deterioration, resulting in increased fragility and fracture risk. With rapid population aging in
Shiyong Zhang, Jinqiu Yuan, Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Osteoporosis Group, Chinese Association of Orthopaedic Surgeons, Youth Osteoporosis Group, Chinese Orthopaedic Association, Chinese Medical Association, Health Communication Branch, Chinese Preventive Medicine Association, Spine and Joint Health Branch, Guangdong Health Care Association, Chinese Health Risk Management Collaboration–Osteoporosis Group (CHRIMAC‐OP), Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Jinqiu Yuan, Xiao Chen, Bo Gao, Yang Guo, Xiaofeng Gong, Junjie Huang, Yafang Huang, Tianyong Hou, Da He, Bin Liu, Yajun Liu, Fangping Li, Ying Li, Wei Li, Jiang Li, Zhihao Li, Xiahong Lin, Houqing Long, Jianwen Mo, Wenfei Ni, Yuanjun Teng, Liang Wang, Xiaobin Wang, Hongli Wang, Nan Wu, Hongfei Xiang, Bin Yan, Dejin Yang, Min Yang, Wei Ye, Hongping Yu, Ziji Zhang, Shiyong Zhang, Xinyu Chen, Ningning Chen, Qiangsheng He, Linmin Hu, Wenjing Li, Zijun Li, Qiji Li, Chengkai Lin, Qingfeng Luo, Tianyi Liu, Ningning Mi, Mina Ma, Jun Shen, Peng She, Huidong Tian, Siqing Wu, Junming Wan, Yongsheng Wang, Bin Xia, Peng Xie, Jinyu Zhao, Fei Zhang, Penghui Zhang, Danni Wang, Lei Cheng, Zhongshi Li, Xinyu Liu, Jing Wang, Shengping Yang, Binsheng Yu   +84 more
wiley   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly

Periodontology 2000, EarlyView.
Abstract Objectives This review synthesizes evidence regarding the prevalence, epidemiological associations, and mechanistic pathways between osteoporosis, periodontal disease, and dental implant therapy. Materials and Methods A literature review was conducted to identify studies focused on: osteoporosis, periodontal disease, and dental implants ...
Samin Sirous, Jaclyn C. Chalmers, Pin‐Ying Li, Yumna Subhani, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Internalization of Sclerostin-GFP.

, 2013
(A) 293 cells stably over-expressing LRP6 (293-LRP6) or containing an empty pcDNA3 vector, were incubated with GFP or Sclerostin-GFP for 1.5 hours at 4°C.
Puck B. van Kasteren (408008), Maarten van Dinther (408002), Juan Zhang (48597), Verena Boschert (408004), Stella E. Weidauer (408003), Christian Frisch (237601), Thomas D. Mueller (240937), Eva-Maria Muth (408005), Achim Knappik (408006), David J. J. de Gorter (408007), Peter ten Dijke (82259)   +10 more
core   +1 more source

Sclerostin Blood Levels Before and After Kidney Transplantation

Kidney & Blood Pressure Research, 2014
Background/Aims: Sclerostin is secreted by osteocytes. As a circulating inhibitor of the Wnt-signaling pathway it inhibits bone formation and contributes to the development of osteoporosis.
Marco Bonani, Daniel Rodriguez, Thomas Fehr, Nilufar Mohebbi, Jens Brockmann, Markus Blum, Nicole Graf, Diana Frey, Rudolf P. Wüthrich   +8 more
doaj   +1 more source

Decoding host–microbial dynamics in peri‐implantitis: Ecosystem‐specific experimental models

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is an inflammatory disease arising within a unique host–microbial–biomaterial ecosystem. Unlike periodontitis, peri‐implant tissues lack a periodontal ligament and epithelial junction integrity and interface with metal oxides on titanium surfaces.
Georgios A. Kotsakis, Davi Araújo, Asaf Wilensky, Juliana Girón Bastidas, Stella Alimperti, Flavia Pirih   +5 more
wiley   +1 more source

Sclerostin and chronic kidney disease

, 2017
Chronic kidney disease (CKD) leads to the development of mineral and skeletal disturbances. They increase the risk of fractures, cardiovascular complications and, in consequence, decrease patients’ lifespan.
Beata Naumnik, Emilia Szablak-Uliszewska, Tomasz Hryszko, Emilia Mierzwińska   +3 more
core   +1 more source