Results 61 to 70 of about 11,659 (170)

Serum Sclerostin Increases After Acute Physical Activity

, 2017
International audiencePhysical activity has a major impact on bone density and on osteoporosis prevention. Sclerostin is produced by osteocytes and inhibits bone formation. The impact of exercise on sclerostin secretion has not been studied so far.
Sornay-Rendu, E., Cyrille B. Confavreux, Marie-Eva Pickering, Confavreux, C. B., Pickering, M. E., Pawel Szulc, Karim Chikh, Simon, M., Carlier, M. C., Marie Simon, Elisabeth Sornay-Rendu, Raby, A. L., Szulc, P., Chikh, Karim, Marie-Christine Carlier, Anne-Lise Raby   +15 more
core   +1 more source

The impact of breast milk relaxin 2, oxytocin, and insulin‐like peptide 3 on neonatal growth parameters in early life

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 6, Page 1479-1487, June 2026.
Abstract Objectives This study aims to quantify the levels of relaxin 2 (RLX2), oxytocin (OXT), and insulin‐like peptide 3 (INSL3) in colostrum (postpartum days 1–5, Visit 1) and mature breast milk (postpartum days 21–35, Visit 2), and to evaluate their associations with neonatal growth outcomes.
Hakan Doneray, Ayse Ozden, Guzide Tavlas, Halil Ibrahim Ozkan   +3 more
wiley   +1 more source

Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis

, 2015
Arti D Shah,1 Dolores Shoback,1,2 E Michael Lewiecki3,4 1Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco, CA, USA; 2Endocrine Research Unit, Department of Medicine, Veterans Affairs Medical ...
Lewiecki EM, Shah AD, Shoback D
core  

Biochemical bone biomarkers in plasma cell dyscrasias

British Journal of Haematology, Volume 208, Issue 6, Page 1909-1923, June 2026.
Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador, Rohit Vijjhalwar, Muhammad Kassim Javaid, Claire M. Edwards, Karthik Ramasamy   +4 more
wiley   +1 more source

Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol

, 2018
Qun Cheng,1–3 Xiaoxing Wu,1,2 Yanping Du,1–3 Wei Hong,1–3 Wenjing Tang,1–3 Huilin Li,1–3 Minmin Chen,1–3 Songbai Zheng3 1Department of Osteoporosis and Bone Disease, Huadong Hospital Affiliated to Fudan University ...
Li H, Cheng Q, Chen M, Zheng S, Du Y, Hong W, Tang W, Wu X   +7 more
core  

Sclerostin stimulates angiogenesis in human endothelial cells

, 2017
Sclerostin, negative regulator of bone formation, has been originally known as an osteocyte product. Recently, it has been also detected in hypertrophic chondrocytes, distinctive cells of avascular cartilage which is invaded by capillaries and then ...
Angela Notarnicola, Giacomina Brunetti, Roberto Tamma, ORANGER, ANGELA, LIPPO, LUCIANA, Silvia Colucci, Domenico Ribatti, Zerlotin, Roberta, RIBATTI, Domenico, COLAIANNI, GRAZIANA, NOTARNICOLA, ANGELA, Maria Grano, GRANO, Maria, Roberta Zerlotin, MORI, GIORGIO, Angela Oranger, COLUCCI, Silvia Concetta, Pignataro, Paolo, Nunzio Cirulli, CARBONE, CLAUDIA, TAMMA, ROBERTO, Giorgio Mori, Claudia Carbone, Colucci, Silvia, Biagio Moretti, Luciana Lippo, Paolo Pignataro, MORETTI, Biagio, BRUNETTI, GIACOMINA, Cirulli, Nunzio, Graziana Colaianni   +30 more
core   +1 more source

Load-sensitive Sclerostin regulation requires TGFβ signaling.

, 2013
Immunohistochemistry shows reduced Sclerostin expression between the loaded and nonloaded tibiae of WT mice, but no difference in Sclerostin expression in tibiae of DNTβRII mice (A).
Tamara Alliston (265049), Jacqueline Nguyen (290539), Daniel Nguyen (290542), Simon Y. Tang (290540)   +3 more
core   +1 more source

Circulating levels of sclerostin predict glycemic improvement after sleeve gastrectomy

, 2021
Among the different effects of bariatric surgery, here we focus on bone-derived inflammatory molecules, and in particular, sclerostin; an osteocyte product potentially associated with cardio-metabolic diseases.
Ministrini S., Carbone F., Montecucco F., Migliola E. N., De Vuono S., Ricci M. A., Boni M., Bonaventura A., Vaudo G., Vecchie A., Lupattelli G.   +10 more
core   +1 more source

Bone overgrowth-associated mutations in LRP4 impair sclerostin-facilitator function.

, 2011
Humans lacking sclerostin display progressive bone overgrowth due to increased bone formation. While it is well established that sclerostin is an osteocyte secreted bone formation inhibitor, the underlying molecular mechanisms are not fully elucidated ...
Boudin, Eveline, Hu, Shouih, Piters, Elke, Van Hul, Wim, Jennes, Karen, Halleux, Christine, Leupin, Olivier, Schirle, Markus, Morvan, Frederic, Bueno-Lozano, Manuel, Ebersbach, Hilmar, Itin, Peter H, Charara, Nadine, Brannetti, Barbara, Kramer, Ina, Geisse, Sabine, Bouwmeester, Tewis, Ramos Fuentes, Feliciano J, De Freitas, Fenna, Bauer, Andreas, Lu, Chris X, Kneissel, Michaela   +21 more
core   +1 more source

Inhibition of Wnt3a signaling by Sclerostin.

, 2013
(A) HEK293TSA cells stably transfected with the Wnt-responsible luciferase reporter construct SuperTOPFlash were stimulated with 1.5 nM recombinant murine Wnt3a and serial dilutions of murine Sclerostin.
Katharina van Pee (491264), Maarten van Dinther (408002), Stella Weidauer (491263), Verena Boschert (408004), Thomas D. Mueller (240937), Eva-Maria Muth (408005), Peter ten Dijke (82259)   +6 more
core   +1 more source