Results 61 to 70 of about 13,851 (214)
, 2023 Additional file 2: Fig. S1. Ocy454 cells were transfected with siRNA to inhibit the secretion of sclerostin. A, B Western blotting of sclerostin protein expression in Ocy454 cells at 48 h after transfection with one of three SOST-siRNAs.
Zengxin Jiang (13827432) +4 more
core +1 more source
The FEBS Journal, EarlyView.Sclerostin (SOST) is a multifunctional extracellular modulator of BMP and Wnt signaling. SOST binds with high affinity to fibrillin‐1 and fibrillin‐2, localizing it to fibrillin microfibrils and regulating its extracellular bioavailability. Fibrillin‐bound SOST cannot engage BMP‐7 prodomain (PD) complexes, revealing a competitive mechanism that ...
Annkatrin Correns +11 more
wiley +1 more source
How accurate is your sclerostin measurement? Comparison between three commercially available sclerostin ELISA kits [PDF]
, 2016 Sclerostin, bone formation antagonist is in the spotlight as a potential biomarker for diseases presenting with associated bone disorders such as chronic kidney disease (CDK-MBD). Accurate measurement of sclerostin is therefore important.
Fisher, Emily +13 more
core +2 more sources
Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers [PDF]
, 2023 Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs).
Ormanji, Milene Subtil +11 more
core +1 more source
The Role of Sclerostin in Bone and Ectopic Calcification [PDF]
International Journal of Molecular Sciences, 2020 Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased in the elderly and in patients with chronic kidney ...
Annelies De Maré +2 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2020 Sclerostin is an important regulator of bone mass involving Wnt/β-catenin signaling pathway. We aimed to obtain the profile of serum sclerostin level and explore its associations with bone metabolism markers and sex hormones in healthy community-dwelling
Yang Xu +10 more
doaj +1 more source
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells [PDF]
, 2016 Sclerostin, a secreted protein encoded by the Sost gene, is produced by osteocytes and is inhibited by osteoblast differentiation and bone formation. Recently, a functional association between bone and fat tissue has been suggested, and a correlation ...
Taihiko Yamaguchi +7 more
core +1 more source
Circulating levels of sclerostin are associated with cardiovascular mortality. [PDF]
PLoS ONE, 2018 Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification.
Cristina Novo-Rodríguez +8 more
doaj +1 more source
Journal of Periodontal Research, EarlyView.Sixty years after the introduction of dental implants, it is clear that soft‐tissue integration is as essential as osseointegration. This review outlines how peri‐implant soft tissues develop, protect, and sometimes fail, revealing key knowledge gaps and new opportunities to improve long‐term implant stability.
Fabiana Aellos +6 more
wiley +1 more source