Results 1 to 10 of about 27,172 (112)
Biomedicines, 2022 Adaptor molecules play a crucial role in signal transduction in immune cells. Several adaptor molecules, such as the linker for the activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), are essential for T cell ...
Jun-ichi Kashiwakura +2 more
doaj +6 more sources
Exploration of Immunology, 2023 Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical domains such as the pleckstrin homology (PH) domain, Src ...
Yuto Sasaki +5 more
doaj +4 more sources
Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications
Exploration of Targeted Anti-tumor TherapyAdaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal ...
Taiga Maemoto +5 more
doaj +5 more sources
Signal-transducing adaptor protein-2 modulates T-cell functions
Exploration of Immunology, 2022 Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades.
Tadashi Matsuda +6 more
doaj +3 more sources
Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases
Experimental Hematology, 2022 Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment.
Naoki Hosen +2 more
exaly +10 more sources
Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis
Biological and Pharmaceutical Bulletin, 2021 Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis.
Jun-Ichi Kashiwakura +2 more
exaly +5 more sources
Biochemical and Biophysical Research Communications, 2021 Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of FcεRI signal transduction in mast cells, other involvement of STAP-2 in mast cell functions is unknown, yet.
Jun-Ichi Kashiwakura +2 more
exaly +4 more sources
Journal of Neuro-Oncology, 2023 Abstract Background Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma.
Di Chen, Lang Hu, Tan Feng
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Hrs, a Mammalian Master Molecule in Vesicular Transport and Protein Sorting, Suppresses the Degradation of ESCRT Proteins Signal Transducing Adaptor Molecule 1 and 2 [PDF]
Journal of Biological Chemistry, 2005 The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the control of cellular functions. We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and signal transducing adaptor molecule (STAM) 1 and -2, which are tyrosine ...
Hironobu Asao, Hideyuki Kobayashi
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Biological and Pharmaceutical Bulletin, 2008 Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7.
Yuichi Sekine +2 more
exaly +5 more sources