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The Functional Properties and Physiological Roles of Signal-Transducing Adaptor Protein-2 in the Pathogenesis of Inflammatory and Immune Disorders [PDF]
Biomedicines, 2022 Adaptor molecules play a crucial role in signal transduction in immune cells. Several adaptor molecules, such as the linker for the activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), are essential for T cell ...
Jun-ichi Kashiwakura +2 more
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Potential therapeutic applications of targeting signal-transducing adaptor protein-2 in autoimmune diseases [PDF]
Exploration of Immunology, 2023 Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical domains such as the pleckstrin homology (PH) domain, Src ...
Yuto Sasaki +5 more
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Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications [PDF]
Exploration of Targeted Anti-tumor TherapyAdaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal ...
Taiga Maemoto +5 more
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Signal-transducing adaptor protein-2 modulates T-cell functions [PDF]
Exploration of Immunology, 2022 Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades.
Tadashi Matsuda +6 more
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Virulence, 2023 Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic pathogen found in humans and pigs, can cause severe clinical infections, and pose public health issues.
Xiaowu Jiang +6 more
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In-cell biochemistry using NMR spectroscopy. [PDF]
PLoS ONE, 2008 Biochemistry and structural biology are undergoing a dramatic revolution. Until now, mostly in vitro techniques have been used to study subtle and complex biological processes under conditions usually remote from those existing in the cell.
David S Burz, Alexander Shekhtman
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Observation on the expression of P62 protein in common neurodegenerative diseases
Chinese Journal of Contemporary Neurology and Neurosurgery, 2019 Objective To evaluate the expression of P62 protein in the characteristic pathological changes of common neurodegenerative diseases and to explore its significance in pathological diagnosis. Methods Eleven cases of neurodegenerative diseases and 3 normal
Yuan⁃yuan WANG +6 more
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Expression of NEDD9 in Transbronchial Biopsies of Lung Adenocarcinoma
Acta Clinica Croatica, 2018 Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium.
Jelena Ostojić +3 more
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Caracterización de la cadena CD3 épsilon en el primate del nuevo mundo Aotus nancymaae
Biomédica: revista del Instituto Nacional de Salud, 2008 Introducción. El complejo asociado al receptor de las células T está constituido por las moléculas CD3 (δ, γ, ε) y las cadenas ζ, todas proteínas transmembrana esenciales para la transducción de señales durante la activación del linfocito y la respuesta ...
Jean Paul Vernot, Hernando del Castillo
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Frontiers in Molecular Neuroscience, 2016 Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an inside-out activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and ...
Marlen Thiere +6 more
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