Results 1 to 10 of about 27,279 (252)

The Functional Properties and Physiological Roles of Signal-Transducing Adaptor Protein-2 in the Pathogenesis of Inflammatory and Immune Disorders [PDF]

Biomedicines, 2022
Adaptor molecules play a crucial role in signal transduction in immune cells. Several adaptor molecules, such as the linker for the activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), are essential for T cell ...
Jun-ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda   +2 more
doaj   +7 more sources

Potential therapeutic applications of targeting signal-transducing adaptor protein-2 in autoimmune diseases [PDF]

Exploration of Immunology, 2023
Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical domains such as the pleckstrin homology (PH) domain, Src ...
Yuto Sasaki, Shoya Kawahara, Yuichi Sekine, Jun-Ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda   +5 more
doaj   +5 more sources

Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications [PDF]

Exploration of Targeted Anti-tumor Therapy
Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal ...
Taiga Maemoto, Yuto Sasaki, Fumiya Okuyama, Yuichi Kitai, Kenji Oritani, Tadashi Matsuda   +5 more
doaj   +6 more sources

Signal-transducing adaptor protein-2 modulates T-cell functions [PDF]

Exploration of Immunology, 2022
Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades.
Tadashi Matsuda, Yuto Sasaki, Kota Kagohashi, Kodai Saitoh, Yuichi Sekine, Jun-Ichi Kashiwakura, Kenji Oritani   +6 more
doaj   +4 more sources

The role of Crk adaptor proteins in T cell adhesion and migration

Frontiers in Immunology, 2015
Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules ...
Noah eIsakov, Alex eBraiman
doaj   +2 more sources

In-cell biochemistry using NMR spectroscopy. [PDF]

PLoS ONE, 2008
Biochemistry and structural biology are undergoing a dramatic revolution. Until now, mostly in vitro techniques have been used to study subtle and complex biological processes under conditions usually remote from those existing in the cell.
David S Burz, Alexander Shekhtman
doaj   +2 more sources

STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation

Scientific Reports
Signal-transducing adaptor protein-2 (STAP-2) is an adaptor molecule involved in several cellular signaling cascades. Here, we attempted to identify novel STAP-2 interacting molecules, and identified c-Cbl associated protein (CAP) as a binding protein ...
Yuichi Sekine, Kazuna Kikkawa, Sachie Honda, Yuto Sasaki, Shoya Kawahara, Akihiro Mizushima, Sumihito Togi, Masahiro Fujimuro, Kenji Oritani, Tadashi Matsuda   +9 more
doaj   +2 more sources

Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases

Experimental Hematology, 2022
Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment.
Michiko Ichii, Kenji Oritani, Jun Toda, Naoki Hosen, Tadashi Matsuda, Yuzuru Kanakura   +5 more
  +10 more sources

Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages [PDF]

The Journal of Immunology, 2006
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies have demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Taro, Yumioka, Tetsuya, Yamamoto, Ryuta, Muromoto, Seiyu, Imoto, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Mayu, Minoguchi, Shizuo, Akira, Akihiko, Yoshimura, Tadashi, Matsuda   +11 more
openaire   +2 more sources

Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma

Journal of Neuro-Oncology, 2023
Abstract Background Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma.
Xinyu Yang, Chunxia Ji, Ying Qi, Jianhan Huang, Lang Hu, Yuan Zhou, Liping Zou, Yi Xia, Feng Tan, Yu Yao, Di Chen   +10 more
openaire   +2 more sources