Results 31 to 40 of about 34,245 (258)

Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection

Frontiers in Immunology, 2017
The mitogen-activated protein kinase (MAPK) cascades are activated in innate immune cells such as macrophages upon the detection of microbial infection, critically regulating the expression of proinflammatory cytokines and chemokines such as TNF-α, IL-6,
Sharol Su Lei Cho, Sharol Su Lei Cho, Jian Han, Jian Han, Sharmy J. James, Sharmy J. James, Chin Wen Png, Chin Wen Png, Madhushanee Weerasooriya, Madhushanee Weerasooriya, Sylvie Alonso, Sylvie Alonso, Yongliang Zhang, Yongliang Zhang   +13 more
doaj   +1 more source

The Role of Signal-Transducing Adaptor Protein-2 in Early T Lymphopoiesis in Thymus

Blood, 2014
Abstract Immune cells show quick responses to infection. Many studies concerning cellular and humoral immunity have focused on the regulation of mature lymphocyte function. However, recent studies revealed that the early stage of hematopoiesis plays an important role in the immune system.
Michiko Ichii, Natsuko Fujita, Daisuke Okuzaki, Tetsuo Maeda, Yuichi Sekine, Shigeyuki Kon, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda, Yuzuru Kanakura   +9 more
openaire   +1 more source

Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells [PDF]

The Journal of Immunology, 2009
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion.
Yuichi, Sekine, Osamu, Ikeda, Satoshi, Tsuji, Chikako, Yamamoto, Ryuta, Muromoto, Asuka, Nanbo, Kenji, Oritani, Akihiko, Yoshimura, Tadashi, Matsuda   +8 more
openaire   +2 more sources

A Mendelian randomized study on the correlation between 91 inflammatory protein levels and the risk of acute myeloid leukemia [PDF]

Zhenduanxue lilun yu shijian
Objective The study aims to analyze the correlation between circulating inflammatory proteins and the risk of acute myeloid leukemia (AML). Methods AML data were obtained from the FinnGen alliance as the outcome. The Genome-wide Association Studies (GWAS)
AN Huihui, WU Tao, LIU Wenhui, TIAN Sirui
doaj   +1 more source

Functional characterization of a short peptidoglycan recognition protein from Chinese giant salamander (Andrias davidianus) [PDF]

, 2017
This work was supported by the National Natural Science Foundation of China (Grant no. 31302221, 31172408 and 31272666) and Jiangsu Province (Grant no.
Chang, Mingxian, Nie, Pin, Qi, Zhitao, Qiao, Guo, Ren, Shisi, Wang, Zisheng, Xu, Qiaoqing, Zhang, Qihuan, Zou, Jun   +8 more
core   +1 more source

Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase [PDF]

The Journal of Immunology, 2007
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin homology- and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Satoshi, Tsuji, Osamu, Ikeda, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Ryuta, Muromoto, Norihiko, Ohbayashi, Akihiko, Yoshimura, Tadashi, Matsuda   +9 more
openaire   +2 more sources

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
Dansako, Hiromichi, Hu, Fengyu, Kato, Nobuyuki, Lemon, Stanley M., McGivern, David R., Welsch, Christoph, Yamane, Daisuke   +6 more
core   +4 more sources

Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2 [PDF]

Journal of Biological Chemistry, 2019
B-cell adaptor protein (BCAP) is a multimodular, multifunctional signal transducer that regulates signal transduction pathways in leukocytes, including macrophages, B-cells, and T-cells. In particular, BCAP suppresses inflammatory signaling by Toll-like receptors (TLRs).
Johannes U. Lauenstein, Atul Udgata, Alex Bartram, Delphine De Sutter, David I. Fisher, Samer Halabi, Sven Eyckerman, Nicholas J. Gay   +7 more
openaire   +2 more sources

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway [PDF]

, 2012
Peer reviewedPublisher ...
Berg, Daniela, Fleckenstein, Corinna, Itohara, Shigeyoshi, Lang, Johannes, Maetzler, Walter, Martin, Heather Louise, Mounsey, Ross Brian, Mustafa, Sarah, Sathe, Kinnari, Schulte, Claudia, Synofzik, Matthis, Teismann, Peter, Vukovic, Zvonimir   +12 more
core   +1 more source

Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes

Biology Direct, 2011
Background Mammalian genome sequence data are being acquired in large quantities and at enormous speeds. We now have a tremendous opportunity to better understand which genes are the most variable or conserved, and what their particular functions and ...
Wang Lei, Liu Fei, Wang Dapeng, Huang Shi, Yu Jun   +4 more
doaj   +1 more source