The Functional Properties and Physiological Roles of Signal-Transducing Adaptor Protein-2 in the Pathogenesis of Inflammatory and Immune Disorders [PDF]
Biomedicines, 2022 Adaptor molecules play a crucial role in signal transduction in immune cells. Several adaptor molecules, such as the linker for the activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), are essential for T cell ...
Jun-ichi Kashiwakura +2 more
doaj +7 more sources
Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications [PDF]
Exploration of Targeted Anti-tumor TherapyAdaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal ...
Taiga Maemoto +5 more
doaj +6 more sources
Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells. [PDF]
PLoS ONE, 2020 ObjectiveSignal-transducing adaptor protein (STAP) family members function as adaptor molecules and are involved in several events during immune responses. Notably however, the biological functions of STAP-1 in other cells are not known.
Jun-Ichi Kashiwakura +12 more
doaj +7 more sources
Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress [PDF]
Haematologica, 2020 Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors.
Michiko Ichii +13 more
doaj +5 more sources
Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma. [PDF]
J Neurooncol, 2023 Abstract Background Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma.
Yang X +10 more
europepmc +4 more sources
Correction: Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells. [PDF]
PLoS ONE, 2021 [This corrects the article DOI: 10.1371/journal.pone.0241440.].
Jun-Ichi Kashiwakura +12 more
doaj +4 more sources
Exploration of Immunology, 2023 Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical domains such as the pleckstrin homology (PH) domain, Src ...
Yuto Sasaki +5 more
doaj +4 more sources
Signal-transducing adaptor protein-2 modulates T-cell functions
Exploration of Immunology, 2022 Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades.
Tadashi Matsuda +6 more
doaj +3 more sources
Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases
Experimental Hematology, 2022 Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment.
Naoki Hosen +2 more
exaly +5 more sources
Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis
Biological and Pharmaceutical Bulletin, 2021 Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and allergic responses. In this study, we investigated the role of STAP-2 in the pathogenesis of autoimmune hepatitis.
Jun-Ichi Kashiwakura +2 more
exaly +5 more sources