Results 21 to 30 of about 27,279 (252)

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress

Haematologica, 2020
Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors. These include STAT5, MyD88 and IκB kinase in macrophages, mast cells, and T cells. There is additional information about roles for STAP-2 in several types of malignant
Michiko Ichii, Kenji Oritani, Jun Toda, Hideaki Saito, Henyun Shi, Hirohiko Shibayama, Daisuke Motooka, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Daisuke Okuzaki, Tadashi Matsuda, Yuzuru Kanakura   +13 more
openaire   +4 more sources

Signal-Transducing Adaptor Protein-2 Modulates Fas-Mediated T Cell Apoptosis by Interacting with Caspase-8 [PDF]

The Journal of Immunology, 2012
Abstract We found that an adaptor protein, signal-transducing adaptor protein (STAP)-2, is a new member of the Fas–death-inducing signaling complex and participates in activation-induced cell death in T cells. STAP-2 enhanced Fas-mediated apoptosis and caspase-8 aggregation and activation in Jurkat T cells.
Yuichi, Sekine, Chikako, Yamamoto, Michinori, Kakisaka, Ryuta, Muromoto, Shigeyuki, Kon, Dai, Ashitomi, Natsuko, Fujita, Akihiko, Yoshimura, Kenji, Oritani, Tadashi, Matsuda   +9 more
openaire   +2 more sources

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase [PDF]

, 2001
After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. The two latter proteins
Magnan, A, Anne Gillet, Arrieumerlou, C, Antoine Magnan, Boyer, C, Malissen, Bernard, Vincenzo Di Bartolo, Mireille Richelme, Marie Malissen, Lin, YL, Gillet, A., Roure, A, Mura, A. M., Boyer, C., Malissen, B, Arrieumerlou, C., Malissen, M., Malissen, M, Roure, A., Richelme, M, Acuto, O, Lin, Y. L., Bernard Malissen, Claude Boyer, Malissen, B., Di Bartolo, V, Cécile Arrieumerlou, Yea-Lih Lin, Agnès Roure, Oreste Acuto, Mura, AM, Acuto, O., Richelme, M., Acuto, Oreste, Di Bartolo, V., Anne-Marie Mura, Gillet, A, Boyer, Claudine, Magnan, A.   +38 more
core   +1 more source

Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells [PDF]

The Journal of Immunology, 2009
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion.
Yuichi, Sekine, Osamu, Ikeda, Satoshi, Tsuji, Chikako, Yamamoto, Ryuta, Muromoto, Asuka, Nanbo, Kenji, Oritani, Akihiko, Yoshimura, Tadashi, Matsuda   +8 more
openaire   +2 more sources

Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection

Frontiers in Immunology, 2017
The mitogen-activated protein kinase (MAPK) cascades are activated in innate immune cells such as macrophages upon the detection of microbial infection, critically regulating the expression of proinflammatory cytokines and chemokines such as TNF-α, IL-6,
Sharol Su Lei Cho, Sharol Su Lei Cho, Jian Han, Jian Han, Sharmy J. James, Sharmy J. James, Chin Wen Png, Chin Wen Png, Madhushanee Weerasooriya, Madhushanee Weerasooriya, Sylvie Alonso, Sylvie Alonso, Yongliang Zhang, Yongliang Zhang   +13 more
doaj   +1 more source

The Role of Signal-Transducing Adaptor Protein-2 in Early T Lymphopoiesis in Thymus

Blood, 2014
Abstract Immune cells show quick responses to infection. Many studies concerning cellular and humoral immunity have focused on the regulation of mature lymphocyte function. However, recent studies revealed that the early stage of hematopoiesis plays an important role in the immune system.
Michiko Ichii, Natsuko Fujita, Daisuke Okuzaki, Tetsuo Maeda, Yuichi Sekine, Shigeyuki Kon, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda, Yuzuru Kanakura   +9 more
openaire   +1 more source

A Mendelian randomized study on the correlation between 91 inflammatory protein levels and the risk of acute myeloid leukemia [PDF]

Zhenduanxue lilun yu shijian
Objective The study aims to analyze the correlation between circulating inflammatory proteins and the risk of acute myeloid leukemia (AML). Methods AML data were obtained from the FinnGen alliance as the outcome. The Genome-wide Association Studies (GWAS)
AN Huihui, WU Tao, LIU Wenhui, TIAN Sirui
doaj   +1 more source

Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase [PDF]

The Journal of Immunology, 2007
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin homology- and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Satoshi, Tsuji, Osamu, Ikeda, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Ryuta, Muromoto, Norihiko, Ohbayashi, Akihiko, Yoshimura, Tadashi, Matsuda   +9 more
openaire   +2 more sources

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. [PDF]

, 2015
<p><b>BACKGROUND: </b>The dynamic interaction between HIV and its host governs the replication of the virus and the study of the virus-host interplay is key to understand the viral lifecycle.
J. Demeulemeester, I. Paron, Schrijvers, Rik, B.Ayele Desimmie, Demeulemeester, Jonas, Debyser, Zeger, Schrijvers, R., Mast, J., J. De Rijck, Desimmie, Belete Ayele, Rijck, Jan de, Debyser, Z., Weydert, Caroline, Demeulemeester, J., De Rijck, Jan, Mast, Jan, R. Gijsbers, Christ, F., Weydert, C., Christ, Frauke, S. Vets, N. Bannert, Paron, I., C. Weydert, Bannert, Norbert, J. Mast, F. Christ, Desimmie, B., Proost, P., Proost, Paul, Vets, S., De Rijck, J., Gijsbers, R., Vets, Sofie, R. Schrijvers, Paron, Igor, P. Proost, Bannert, N., Gijsbers, Rik, Z. Debyser   +39 more
core   +1 more source

Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2 [PDF]

Journal of Biological Chemistry, 2019
B-cell adaptor protein (BCAP) is a multimodular, multifunctional signal transducer that regulates signal transduction pathways in leukocytes, including macrophages, B-cells, and T-cells. In particular, BCAP suppresses inflammatory signaling by Toll-like receptors (TLRs).
Johannes U. Lauenstein, Atul Udgata, Alex Bartram, Delphine De Sutter, David I. Fisher, Samer Halabi, Sven Eyckerman, Nicholas J. Gay   +7 more
openaire   +2 more sources