Results 21 to 30 of about 27,271 (211)

Caracterización de la cadena CD3 épsilon en el primate del nuevo mundo Aotus nancymaae

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. El complejo asociado al receptor de las células T está constituido por las moléculas CD3 (δ, γ, ε) y las cadenas ζ, todas proteínas transmembrana esenciales para la transducción de señales durante la activación del linfocito y la respuesta ...
Jean Paul Vernot, Hernando del Castillo
doaj   +1 more source

Integrin activation through the hematopoietic adapter molecule ADAP regulates dendritic development of hippocampal neurons

Frontiers in Molecular Neuroscience, 2016
Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an inside-out activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and ...
Marlen Thiere, Stefanie Kliche, Bettina Müller, Jan Teuber, Isabell Nold, Oliver Stork, Oliver Stork   +6 more
doaj   +1 more source

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress

Haematologica, 2020
Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors. These include STAT5, MyD88 and IκB kinase in macrophages, mast cells, and T cells. There is additional information about roles for STAP-2 in several types of malignant
Michiko Ichii, Kenji Oritani, Jun Toda, Hideaki Saito, Henyun Shi, Hirohiko Shibayama, Daisuke Motooka, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Daisuke Okuzaki, Tadashi Matsuda, Yuzuru Kanakura   +13 more
openaire   +4 more sources

The role of Crk adaptor proteins in T cell adhesion and migration

Frontiers in Immunology, 2015
Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules ...
Noah eIsakov, Alex eBraiman
doaj   +1 more source

Signal-Transducing Adaptor Protein-2 Modulates Fas-Mediated T Cell Apoptosis by Interacting with Caspase-8 [PDF]

The Journal of Immunology, 2012
Abstract We found that an adaptor protein, signal-transducing adaptor protein (STAP)-2, is a new member of the Fas–death-inducing signaling complex and participates in activation-induced cell death in T cells. STAP-2 enhanced Fas-mediated apoptosis and caspase-8 aggregation and activation in Jurkat T cells.
Yuichi, Sekine, Chikako, Yamamoto, Michinori, Kakisaka, Ryuta, Muromoto, Shigeyuki, Kon, Dai, Ashitomi, Natsuko, Fujita, Akihiko, Yoshimura, Kenji, Oritani, Tadashi, Matsuda   +9 more
openaire   +2 more sources

Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1α-Induced Chemotaxis in T Cells [PDF]

The Journal of Immunology, 2009
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a YXXQ motif in its C-terminal region. Our previous studies revealed that STAP-2 regulates integrin-mediated T cell adhesion.
Yuichi, Sekine, Osamu, Ikeda, Satoshi, Tsuji, Chikako, Yamamoto, Ryuta, Muromoto, Asuka, Nanbo, Kenji, Oritani, Akihiko, Yoshimura, Tadashi, Matsuda   +8 more
openaire   +2 more sources

Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection

Frontiers in Immunology, 2017
The mitogen-activated protein kinase (MAPK) cascades are activated in innate immune cells such as macrophages upon the detection of microbial infection, critically regulating the expression of proinflammatory cytokines and chemokines such as TNF-α, IL-6,
Sharol Su Lei Cho, Sharol Su Lei Cho, Jian Han, Jian Han, Sharmy J. James, Sharmy J. James, Chin Wen Png, Chin Wen Png, Madhushanee Weerasooriya, Madhushanee Weerasooriya, Sylvie Alonso, Sylvie Alonso, Yongliang Zhang, Yongliang Zhang   +13 more
doaj   +1 more source

The Role of Signal-Transducing Adaptor Protein-2 in Early T Lymphopoiesis in Thymus

Blood, 2014
Abstract Immune cells show quick responses to infection. Many studies concerning cellular and humoral immunity have focused on the regulation of mature lymphocyte function. However, recent studies revealed that the early stage of hematopoiesis plays an important role in the immune system.
Michiko Ichii, Natsuko Fujita, Daisuke Okuzaki, Tetsuo Maeda, Yuichi Sekine, Shigeyuki Kon, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda, Yuzuru Kanakura   +9 more
openaire   +1 more source

A Mendelian randomized study on the correlation between 91 inflammatory protein levels and the risk of acute myeloid leukemia [PDF]

Zhenduanxue lilun yu shijian
Objective The study aims to analyze the correlation between circulating inflammatory proteins and the risk of acute myeloid leukemia (AML). Methods AML data were obtained from the FinnGen alliance as the outcome. The Genome-wide Association Studies (GWAS)
AN Huihui, WU Tao, LIU Wenhui, TIAN Sirui
doaj   +1 more source

Signal-Transducing Adaptor Protein-2 Regulates Integrin-Mediated T Cell Adhesion through Protein Degradation of Focal Adhesion Kinase [PDF]

The Journal of Immunology, 2007
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin homology- and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Satoshi, Tsuji, Osamu, Ikeda, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Ryuta, Muromoto, Norihiko, Ohbayashi, Akihiko, Yoshimura, Tadashi, Matsuda   +9 more
openaire   +2 more sources