Results 21 to 30 of about 34,245 (258)
Frontiers in Molecular Neuroscience, 2016 Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an inside-out activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and ...
Marlen Thiere +6 more
doaj +1 more source
Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis. [PDF]
, 2017 Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or ...
Molfetta, R +3 more
core +2 more sources
Haematologica, 2020 Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors. These include STAT5, MyD88 and IκB kinase in macrophages, mast cells, and T cells. There is additional information about roles for STAP-2 in several types of malignant
Michiko Ichii +13 more
openaire +4 more sources
Signal-Transducing Adaptor Protein-2 Modulates Fas-Mediated T Cell Apoptosis by Interacting with Caspase-8 [PDF]
The Journal of Immunology, 2012 Abstract We found that an adaptor protein, signal-transducing adaptor protein (STAP)-2, is a new member of the Fas–death-inducing signaling complex and participates in activation-induced cell death in T cells. STAP-2 enhanced Fas-mediated apoptosis and caspase-8 aggregation and activation in Jurkat T cells.
Yuichi, Sekine +9 more
openaire +2 more sources
The role of Crk adaptor proteins in T cell adhesion and migration
Frontiers in Immunology, 2015 Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules ...
Noah eIsakov, Alex eBraiman
doaj +1 more source
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes [PDF]
, 2006 Ubiquitylation is a key regulator of protein trafficking, and much about the functions of ubiquitin ligases, which add ubiquitin to substrates in this regulation, has recently come to light.
Millard, Stephen A., Wood, Susan M.
core +2 more sources
Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]
, 2015 The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri +5 more
core +2 more sources
Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]
, 2016 B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke +2 more
core +1 more source
Proteins and mechanisms involved in endosomal sorting of the epidermal growth factor receptor [PDF]
, 2007 Signaling from growth factor receptors is tightly regulated. Failure of this regulation can lead to overstimulation of growth, proliferation and differentiation, and is often observed in cancer. The epidermal growth factor receptor (EGFR) is desensitized
Grøvdal, Lene Melsæther
core +1 more source
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. [PDF]
, 2014 Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif.
Anwar, Saba +5 more
core +2 more sources