Results 11 to 20 of about 3,262,636 (250)

The role of Crk adaptor proteins in T cell adhesion and migration [PDF]

Frontiers in Immunology, 2015
Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules ...
Noah eIsakov, Alex eBraiman
doaj   +2 more sources

Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases

Experimental Hematology, 2022
Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment.
Michiko Ichii, Kenji Oritani, Jun Toda, Naoki Hosen, Tadashi Matsuda, Yuzuru Kanakura   +5 more
  +10 more sources

Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages [PDF]

The Journal of Immunology, 2006
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies have demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Taro, Yumioka, Tetsuya, Yamamoto, Ryuta, Muromoto, Seiyu, Imoto, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Mayu, Minoguchi, Shizuo, Akira, Akihiko, Yoshimura, Tadashi, Matsuda   +11 more
openaire   +2 more sources

Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma

Journal of Neuro-Oncology, 2023
Abstract Background Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma.
Xinyu Yang, Chunxia Ji, Ying Qi, Jianhan Huang, Lang Hu, Yuan Zhou, Liping Zou, Yi Xia, Feng Tan, Yu Yao, Di Chen   +10 more
openaire   +2 more sources

Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130 [PDF]

FEBS Letters, 1998
The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin‐6 (IL‐6)‐type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of gp130 occurs signal‐independent.
Thiel, Stefan, Dahmen, Heike, Martens, Astrid, Müller-Newen, Gerhard, Schaper, Fred, Heinrich, Peter, Graeve, Lutz   +6 more
openaire   +3 more sources

Signal Transducing Adaptor Protein-2 Represses Epithelial-Mesenchymal Transition by Downregulating SMAD-Mediated ZEB1 Expression. [PDF]

Genes Cells
Epithelial‐mesenchymal transition (EMT) is crucial for initiation of cancer metastasis. EMT‐induced epithelial cancer cells gain stemness characteristics, which enhance cancer malignancy and chemoresistance.
Okuyama F, Kitai Y, Li Z, Ishii M, Muromoto R, Matsuda T.   +5 more
europepmc   +2 more sources

The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling [PDF]

Molecular and Cellular Biology, 2002
The integrin family of cell adhesion receptors are important for a diverse set of biological responses during development. Although many integrins have been shown to engage a similar set of cytoplasmic effector proteins in vitro, the importance of these proteins in the biological events mediated by different integrin receptors and ligands is uncertain.
Margit, Hagel, Elizabeth L, George, Ann, Kim, Rulla, Tamimi, Sarah L, Opitz, Christopher E, Turner, Akira, Imamoto, Sheila M, Thomas   +7 more
openaire   +2 more sources

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. [PDF]

The EMBO journal, 1996
The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled receptors are not well defined, the mechanisms of Ras activation by receptor tyrosine kinases have recently been elucidated biochemically and genetically ...
Y. Chen, D. Grall, A. E. Salcini, P. G. Pelicci, J. Pouysségur, E. Van Obberghen Schilling   +5 more
openaire   +4 more sources

Signal-Transducing Adaptor Protein-2 Controls the IgE-Mediated, Mast Cell–Mediated Anaphylactic Responses [PDF]

The Journal of Immunology, 2014
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules. In the current study, we clarified the physiological role of STAP-2 in mast cell function, a key mediator of IgE ...
Yuichi, Sekine, Keigo, Nishida, Satoru, Yamasaki, Ryuta, Muromoto, Shigeyuki, Kon, Jun-Ichi, Kashiwakura, Kodai, Saitoh, Sumihito, Togi, Akihiko, Yoshimura, Kenji, Oritani, Tadashi, Matsuda   +10 more
openaire   +2 more sources

Complex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain. [PDF]

, 2012
Scaffold proteins have an important role in the regulation of signal propagation. These proteins do not possess any enzymatic activity but can contribute to the formation of multiprotein complexes.
Roopesh Udupa, Bőgel Gábor, Annamária Balázs, Gábor Bőgel, Udupa Roopesh, Szabó Beáta, Beáta Szabó, Balázs Annamária, Balázs, Annamária, Fekete Anna, Buday László, Pesti Szabolcs, Szabolcs Pesti, László Buday, Pesti, Szabolcs, Anna Fekete, Udupa, Roopesh   +16 more
core   +1 more source