Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases
Experimental Hematology, 2022 Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment.
Michiko Ichii +5 more
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Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages [PDF]
The Journal of Immunology, 2006 Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies have demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine +11 more
openaire +2 more sources
Journal of Neuro-Oncology, 2023 Abstract Background Glioma is the most malignant primary brain tumor with a poor survival time. The tumour microenvironment, especially glioma-associated microglia/macrophages (GAMs), plays an important role in the pathogenesis of glioma.
Xinyu Yang +10 more
openaire +2 more sources
Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130 [PDF]
FEBS Letters, 1998 The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin‐6 (IL‐6)‐type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of gp130 occurs signal‐independent.
Thiel, Stefan +6 more
openaire +3 more sources
The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling [PDF]
Molecular and Cellular Biology, 2002 The integrin family of cell adhesion receptors are important for a diverse set of biological responses during development. Although many integrins have been shown to engage a similar set of cytoplasmic effector proteins in vitro, the importance of these proteins in the biological events mediated by different integrin receptors and ligands is uncertain.
Margit, Hagel +7 more
openaire +2 more sources
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. [PDF]
The EMBO Journal, 1996 The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled receptors are not well defined, the mechanisms of Ras activation by receptor tyrosine kinases have recently been elucidated biochemically and genetically ...
Y. Chen +5 more
openaire +3 more sources
Signal-Transducing Adaptor Protein-2 Controls the IgE-Mediated, Mast Cell–Mediated Anaphylactic Responses [PDF]
The Journal of Immunology, 2014 Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules. In the current study, we clarified the physiological role of STAP-2 in mast cell function, a key mediator of IgE ...
Yuichi, Sekine +10 more
openaire +2 more sources
The emerging and diverse roles of Src-like adaptor proteins in health and disease [PDF]
, 2014 Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered.
Baricza, Eszter +4 more
core +3 more sources
Caracterización de la cadena CD3 épsilon en el primate del nuevo mundo Aotus nancymaae
Biomédica: revista del Instituto Nacional de Salud, 2008 Introducción. El complejo asociado al receptor de las células T está constituido por las moléculas CD3 (δ, γ, ε) y las cadenas ζ, todas proteínas transmembrana esenciales para la transducción de señales durante la activación del linfocito y la respuesta ...
Jean Paul Vernot, Hernando del Castillo
doaj +1 more source
The essential role of mitochondrial dynamics in antiviral immunity. [PDF]
, 2018 Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun +3 more
core +2 more sources