Results 11 to 20 of about 27,271 (211)

Signal-transducing adaptor protein-2 modulates T-cell functions

Exploration of Immunology
Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades. Signal-transducing adaptor protein-2 (STAP-2) contains typical features of adaptor proteins, like a pleckstrin homology (PH)
Yuichi Sekine, Tadashi Matsuda, Kenji Oritani   +2 more
exaly   +1 more source

Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages [PDF]

The Journal of Immunology, 2006
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies have demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways.
Yuichi, Sekine, Taro, Yumioka, Tetsuya, Yamamoto, Ryuta, Muromoto, Seiyu, Imoto, Kenji, Sugiyma, Kenji, Oritani, Kazuya, Shimoda, Mayu, Minoguchi, Shizuo, Akira, Akihiko, Yoshimura, Tadashi, Matsuda   +11 more
openaire   +2 more sources

Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130 [PDF]

FEBS Letters, 1998
The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin‐6 (IL‐6)‐type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of gp130 occurs signal‐independent.
Thiel, Stefan, Dahmen, Heike, Martens, Astrid, Müller-Newen, Gerhard, Schaper, Fred, Heinrich, Peter, Graeve, Lutz   +6 more
openaire   +3 more sources

Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition

Virulence, 2023
Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic pathogen found in humans and pigs, can cause severe clinical infections, and pose public health issues.
Xiaowu Jiang, Guijun Yu, Lexin Zhu, Abubakar Siddique, Dongbo Zhan, Linhua Zhou, Min Yue   +6 more
doaj   +1 more source

In-cell biochemistry using NMR spectroscopy. [PDF]

PLoS ONE, 2008
Biochemistry and structural biology are undergoing a dramatic revolution. Until now, mostly in vitro techniques have been used to study subtle and complex biological processes under conditions usually remote from those existing in the cell.
David S Burz, Alexander Shekhtman
doaj   +1 more source

The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling [PDF]

Molecular and Cellular Biology, 2002
The integrin family of cell adhesion receptors are important for a diverse set of biological responses during development. Although many integrins have been shown to engage a similar set of cytoplasmic effector proteins in vitro, the importance of these proteins in the biological events mediated by different integrin receptors and ligands is uncertain.
Margit, Hagel, Elizabeth L, George, Ann, Kim, Rulla, Tamimi, Sarah L, Opitz, Christopher E, Turner, Akira, Imamoto, Sheila M, Thomas   +7 more
openaire   +2 more sources

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. [PDF]

The EMBO journal, 1996
The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled receptors are not well defined, the mechanisms of Ras activation by receptor tyrosine kinases have recently been elucidated biochemically and genetically ...
Y. Chen, D. Grall, A. E. Salcini, P. G. Pelicci, J. Pouysségur, E. Van Obberghen Schilling   +5 more
openaire   +4 more sources

Observation on the expression of P62 protein in common neurodegenerative diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To evaluate the expression of P62 protein in the characteristic pathological changes of common neurodegenerative diseases and to explore its significance in pathological diagnosis. Methods Eleven cases of neurodegenerative diseases and 3 normal
Yuan⁃yuan WANG, Ming⁃wei ZHU, Lu⁃ning WANG, Hong⁃hong ZHANG, Ya⁃zhuo HU, Zhi⁃tao HAN , Ying⁃han ZHANG   +6 more
doaj   +1 more source

Signal-Transducing Adaptor Protein-2 Controls the IgE-Mediated, Mast Cell–Mediated Anaphylactic Responses [PDF]

The Journal of Immunology, 2014
Abstract Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules. In the current study, we clarified the physiological role of STAP-2 in mast cell function, a key mediator of IgE ...
Yuichi, Sekine, Keigo, Nishida, Satoru, Yamasaki, Ryuta, Muromoto, Shigeyuki, Kon, Jun-Ichi, Kashiwakura, Kodai, Saitoh, Sumihito, Togi, Akihiko, Yoshimura, Kenji, Oritani, Tadashi, Matsuda   +10 more
openaire   +2 more sources

Expression of NEDD9 in Transbronchial Biopsies of Lung Adenocarcinoma

Acta Clinica Croatica, 2018
Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium.
Jelena Ostojić, Luka Brčić, Pero Hrabač, Sven Seiwerth   +3 more
doaj   +1 more source