Results 101 to 110 of about 13,466 (213)

Sclerostin stimulates angiogenesis in human endothelial cells

, 2017
Sclerostin, negative regulator of bone formation, has been originally known as an osteocyte product. Recently, it has been also detected in hypertrophic chondrocytes, distinctive cells of avascular cartilage which is invaded by capillaries and then ...
Angela Notarnicola, Giacomina Brunetti, Roberto Tamma, ORANGER, ANGELA, LIPPO, LUCIANA, Silvia Colucci, Domenico Ribatti, Zerlotin, Roberta, RIBATTI, Domenico, COLAIANNI, GRAZIANA, NOTARNICOLA, ANGELA, Maria Grano, GRANO, Maria, Roberta Zerlotin, MORI, GIORGIO, Angela Oranger, COLUCCI, Silvia Concetta, Pignataro, Paolo, Nunzio Cirulli, CARBONE, CLAUDIA, TAMMA, ROBERTO, Giorgio Mori, Claudia Carbone, Colucci, Silvia, Biagio Moretti, Luciana Lippo, Paolo Pignataro, MORETTI, Biagio, BRUNETTI, GIACOMINA, Cirulli, Nunzio, Graziana Colaianni   +30 more
core   +1 more source

Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults—A Narrative Review

Orthopaedic Surgery, Volume 18, Issue 9, Page 1785-1803, September 2026.
This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu, Fan Xu, Maoqiang Fan, Yao Liu, Zhe Song   +4 more
wiley   +1 more source

Associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing maintenance hemodialysis

BMC Nephrology, 2018
Background Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD).
Aiqun Chen, Ying Sun, Ju Cui, Ban Zhao, Haitao Wang, Xianguang Chen, Yonghui Mao   +6 more
doaj   +1 more source

Bone overgrowth-associated mutations in LRP4 impair sclerostin-facilitator function.

, 2011
Humans lacking sclerostin display progressive bone overgrowth due to increased bone formation. While it is well established that sclerostin is an osteocyte secreted bone formation inhibitor, the underlying molecular mechanisms are not fully elucidated ...
Boudin, Eveline, Hu, Shouih, Piters, Elke, Van Hul, Wim, Jennes, Karen, Halleux, Christine, Leupin, Olivier, Schirle, Markus, Morvan, Frederic, Bueno-Lozano, Manuel, Ebersbach, Hilmar, Itin, Peter H, Charara, Nadine, Brannetti, Barbara, Kramer, Ina, Geisse, Sabine, Bouwmeester, Tewis, Ramos Fuentes, Feliciano J, De Freitas, Fenna, Bauer, Andreas, Lu, Chris X, Kneissel, Michaela   +21 more
core   +1 more source

Sclerostin: a new biomarker of interest in nephrology

, 2015
peer reviewedSclerostin is an osteocyte-specific glycoprotein secreted by the osteocyte and involved in the regulation of bone mass. High sclerostin levels are associated with osteoporosis, whereas low sclerostin levels are correlated with higher bone ...
Zaoui, Ph., DELANAYE, Pierre, Massy, Z., Souberbielle, Jean-Claude, Urena-Torres, P., Carlier, M.C., Kamel, S., Jean, Guillaume, Fouque, Denis, Bargnoux, A.S., CAVALIER, Etienne, Mercadal, L., Pelletier, Solenne, Lafage-Proust, Marie-Hélène, Guérin, A., Arnaud, J., Hannedouche, T., Jean, G., Boutten, A, Prié, D., Pieroni, L., Laville, M., Cristol, J.P., Brunet, Ph.   +23 more
core   +1 more source

Sclerostin – új terápiás célpont osteoporosisban

, 2017
A sclerostinnak, az osteocyták által termelt glikoproteinnek csontanyagcserében betöltött szerepe kapcsán merült fel terápiás célpontként való hasznosíthatósága.
Pratz Anita, Nagy, György
core  

Inhibition of Wnt3a signaling by Sclerostin.

, 2013
(A) HEK293TSA cells stably transfected with the Wnt-responsible luciferase reporter construct SuperTOPFlash were stimulated with 1.5 nM recombinant murine Wnt3a and serial dilutions of murine Sclerostin.
Katharina van Pee (491264), Maarten van Dinther (408002), Stella Weidauer (491263), Verena Boschert (408004), Thomas D. Mueller (240937), Eva-Maria Muth (408005), Peter ten Dijke (82259)   +6 more
core   +1 more source

The regulation of the sclerostin gene and the catabolic effects of sclerostin protein on bone. [PDF]

, 2014
Age and disease-related bone loss is a major health issue. Bone tissue is constantly remodelled throughout life in order to maintain a healthy skeleton and bone loss is caused by an imbalance in the remodelling process.
Wijenayaka, Amugoda Kankanange Asiri R.
core  

Impact of elevated sclerostin levels on bone resorption: unravelling structural changes and mineral metabolism disruption

Bone & Joint Research
Aims: The physiological function of sclerostin remains unknown. Sclerostin is synthesized by osteocytes and operates by inhibiting the Wnt/β-catenin pathway. Similarly, it is well established that low levels of sclerostin lead to enhanced bone formation
María Encarnacion Rodríguez-Ortiz, Juan Miguel Díaz-Tocados, Ana Isabel Torralbo, Karen Valdés-Díaz, Antonio Rivas-Domínguez, Fátima Guerrero, Irene Reina-Alfonso, Manuel Naves-Díaz, Cristina Alonso-Montes, Cristian Rodelo-Haad, Mariano Rodríguez, Juan Rafael Muñoz-Castañeda, IMIBIC Nephrology Group   +12 more
doaj   +1 more source

Role and mechanism of action of Sclerostin in bone

, 2017
After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass human syndromes Van Buchem disease and sclerosteosis, extensive animal experimentation and clinical studies demonstrated that sclerostin plays a critical role in
Sato, Amy Y., Bellido, Teresita, Delgado-Calle, Jesus   +2 more
core   +1 more source