Results 101 to 110 of about 13,851 (214)

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Aging Cell, Volume 25, Issue 10, October 2026.
Our studies for the first time underscore the feasibility of long‐term SIRT6 activation as a pharmacological strategy to maintain the health of the intervertebral disc in the aging spine. ABSTRACT Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain.
Pranay Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah E. Bell, Mallory Toci, Olivia Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud   +11 more
wiley   +1 more source

Chinese Guideline on Risk Management of Osteoporosis in the General Public

Orthopaedic Surgery, Volume 18, Issue 10, Page 2015-2031, October 2026.
Summary of the background, key recommendations, and expected impact of the public guideline for osteoporosis risk management. ABSTRACT Background Osteoporosis is a common chronic skeletal disorder characterized by decreased bone mass and microarchitectural deterioration, resulting in increased fragility and fracture risk. With rapid population aging in
Shiyong Zhang, Jinqiu Yuan, Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Osteoporosis Group, Chinese Association of Orthopaedic Surgeons, Youth Osteoporosis Group, Chinese Orthopaedic Association, Chinese Medical Association, Health Communication Branch, Chinese Preventive Medicine Association, Spine and Joint Health Branch, Guangdong Health Care Association, Chinese Health Risk Management Collaboration–Osteoporosis Group (CHRIMAC‐OP), Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Jinqiu Yuan, Xiao Chen, Bo Gao, Yang Guo, Xiaofeng Gong, Junjie Huang, Yafang Huang, Tianyong Hou, Da He, Bin Liu, Yajun Liu, Fangping Li, Ying Li, Wei Li, Jiang Li, Zhihao Li, Xiahong Lin, Houqing Long, Jianwen Mo, Wenfei Ni, Yuanjun Teng, Liang Wang, Xiaobin Wang, Hongli Wang, Nan Wu, Hongfei Xiang, Bin Yan, Dejin Yang, Min Yang, Wei Ye, Hongping Yu, Ziji Zhang, Shiyong Zhang, Xinyu Chen, Ningning Chen, Qiangsheng He, Linmin Hu, Wenjing Li, Zijun Li, Qiji Li, Chengkai Lin, Qingfeng Luo, Tianyi Liu, Ningning Mi, Mina Ma, Jun Shen, Peng She, Huidong Tian, Siqing Wu, Junming Wan, Yongsheng Wang, Bin Xia, Peng Xie, Jinyu Zhao, Fei Zhang, Penghui Zhang, Danni Wang, Lei Cheng, Zhongshi Li, Xinyu Liu, Jing Wang, Shengping Yang, Binsheng Yu   +84 more
wiley   +1 more source

Inhibition of Sclerostin function by antibodies.

, 2013
(A) Sclerostin-GFP was pre-incubated with Fc or the different Fabs raised against Sclerostin for 30 minutes at room temperature, next the mixtures were added to 293-LRP6 cells for 1.5h at 4°C.
Puck B. van Kasteren (408008), Maarten van Dinther (408002), Juan Zhang (48597), Verena Boschert (408004), Stella E. Weidauer (408003), Christian Frisch (237601), Thomas D. Mueller (240937), Eva-Maria Muth (408005), Achim Knappik (408006), David J. J. de Gorter (408007), Peter ten Dijke (82259)   +10 more
core   +1 more source

Sclerostin inhibits interleukin-1β-induced late stage chondrogenic differentiation through downregulation of Wnt/β-catenin signaling pathway.

PLoS ONE, 2020
It is known that Wnt/β-catenin signaling induces endochondral ossification and plays a significant role in the pathophysiology of osteoarthritis (OA). Sclerostin is a potent inhibitor of the Wnt/β-catenin signaling pathway.
Kazuma Miyatake, Ken Kumagai, Sosuke Imai, Yasuteru Yamaguchi, Yutaka Inaba   +4 more
doaj   +1 more source

Sclerostin: clinical insights in muscle–bone crosstalk

, 2023
Sclerostin, a protein encoded by the sclerostin (SOST) gene, is mostly expressed in osteocytes. First described in the pathogenesis of three disorders, sclerosteosis, van Buchem’s disease, and craniodiaphyseal dysplasia, sclerostin has been identified as
Moretti, Antimo, Iolascon, Giovanni, Giovanni Iolascon, Antimo Moretti   +3 more
core   +1 more source

Serum Sclerostin Increases After Acute Physical Activity

, 2017
International audiencePhysical activity has a major impact on bone density and on osteoporosis prevention. Sclerostin is produced by osteocytes and inhibits bone formation. The impact of exercise on sclerostin secretion has not been studied so far.
Sornay-Rendu, E., Cyrille B. Confavreux, Marie-Eva Pickering, Confavreux, C. B., Pickering, M. E., Pawel Szulc, Karim Chikh, Simon, M., Carlier, M. C., Marie Simon, Elisabeth Sornay-Rendu, Raby, A. L., Szulc, P., Chikh, Karim, Marie-Christine Carlier, Anne-Lise Raby   +15 more
core   +1 more source

Associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing maintenance hemodialysis

BMC Nephrology, 2018
Background Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD).
Aiqun Chen, Ying Sun, Ju Cui, Ban Zhao, Haitao Wang, Xianguang Chen, Yonghui Mao   +6 more
doaj   +1 more source

Elevated circulating sclerostin concentrations in individuals with High Bone Mass, with and without LRP5 mutations [PDF]

, 2014
Context: The role and importance of circulating sclerostin is poorly understood. High Bone Mass (HBM) caused by activating LRP5 mutations has been reported to be associated with increased plasma sclerostin concentrations; whether the same applies to HBM ...
Duncan, Emma L., Tobias, Jonathan H., Poole, Kenneth E S, Poole, Ken E S, Rittweger, Jörn, Rittweger, J, McCloskey, Eugene V., Poole, Kenneth E. S., Smith, GD, Smith, George Davey, Fraser, WD, Gregson, Celia L., Poole, K, Tobias, Jonathan H, Fraser, William D., Duncan, EL, McCloskey, Eugene V, Duncan, Emma L, McCloskey, EV, Gregson, Celia L, Fraser, William D, Smith, Davey George, Poole, Kenneth E.S., McCloskey, Eugene   +23 more
core   +2 more sources

Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling [PDF]

, 2011
Sclerostin is an extracellular negative regulator of bone formation that is a recognized therapeutic target for osteoporosis therapy. In the present study, we performed DNA aptamer selection against sclerostin, then characterized aptamer-sclerostin ...
Celine Chan, Ka To Shum, Leung, CM, Julian A. Tanner, Ching-Man Leung, Chan, C, Shum, KT, Tanner, JA   +7 more
core   +1 more source

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction

, 2016
Item does not contain fulltextSclerostin, an inhibitor of the Wnt/beta-catenin pathway, has anti-anabolic effects on bone formation by negatively regulating osteoblast differentiation.
Beckmann, D., Fennen, M., Dankbar, B., Hartmann, Christine, Frank, S., Wehmeyer, Corinna, Stratis, A., Korb-Pap, A., Frank, Svetlana, Kamradt, T., Kramer, I., Paruzel, Peter, van den Berg, Wim, Paruzel, P., Böttcher, Martin, Stratis, Athanasios, König, Ulrich, Held, A., Kneissel, Michaela, Kamradt, Thomas, Held, Annelena, Wehmeyer, C., Bottcher, M., Hartmann, C., Berg, W.B. van den, Dankbar, Berno, Fennen, Michelle, Cromme, Christoph, Pap, Thomas, Kneissel, M., Kramer, Ina, Korb-Pap, Adelheid, Pap, T., Cromme, C., Konig, U., Beckmann, Denise   +35 more
core   +1 more source