Results 111 to 120 of about 13,851 (214)
Bone overgrowth-associated mutations in LRP4 impair sclerostin-facilitator function.
, 2011 Humans lacking sclerostin display progressive bone overgrowth due to increased bone formation. While it is well established that sclerostin is an osteocyte secreted bone formation inhibitor, the underlying molecular mechanisms are not fully elucidated ...
Boudin, Eveline +21 more
core +1 more source
Internalization of Sclerostin-GFP.
, 2013 (A) 293 cells stably over-expressing LRP6 (293-LRP6) or containing an empty pcDNA3 vector, were incubated with GFP or Sclerostin-GFP for 1.5 hours at 4°C.
Puck B. van Kasteren (408008) +10 more
core +1 more source
Sclerostin – új terápiás célpont osteoporosisban
, 2017 A sclerostinnak, az osteocyták által termelt glikoproteinnek csontanyagcserében betöltött szerepe kapcsán merült fel terápiás célpontként való hasznosíthatósága.
Pratz Anita, Nagy, György
core
Sclerostin antibodies in osteoporosis: latest evidence and therapeutic potential
, 2017 Sclerostin is an osteocyte-derived glycoprotein that inhibits Wnt/β-catenin signaling and activation of osteoblast function, thereby inhibiting bone formation. It plays a vital role in the regulation of skeletal growth.
Michael R. McClung
core +1 more source
Sclerostin levels in patients with acromegaly
Endokrynologia PolskaAcromegaly is a rare, endocrine condition characterized by autonomous excessive secretion of growth hormone, causing numerous complications, including impairment of bone microarchitecture. The increased bone turnover observed in acromegaly can lead to bone fragility and elevated risk of vertebral fractures despite normal bone mineral density measured ...
Arnika, Wydra +4 more
openaire +2 more sources
Gene expression of LRP4/5/6 in response to sclerostin.
, 2019 Expression of (A) LRP4, (B) LRP5, and (C) LRP6 after 48 hours of exogenous sclerostin. All data were normalized to the control 0 ng/ml sclerostin data represented by the dashed line.
Rachel C. Nordberg (7465043) +4 more
core +1 more source
Bone & Joint ResearchAims: The physiological function of sclerostin remains unknown. Sclerostin is synthesized by osteocytes and operates by inhibiting the Wnt/β-catenin pathway. Similarly, it is well established that low levels of sclerostin lead to enhanced bone formation
María Encarnacion Rodríguez-Ortiz +12 more
doaj +1 more source
Role and mechanism of action of Sclerostin in bone
, 2017 After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass human syndromes Van Buchem disease and sclerosteosis, extensive animal experimentation and clinical studies demonstrated that sclerostin plays a critical role in
Sato, Amy Y. +2 more
core +1 more source
Sclerostin and the Unloading of Bone [PDF]
Journal of Bone and Mineral Research, 2009 openaire +2 more sources
Progress of studies on sclerostin’s role in vascular calcification of chronic kidney disease
Linchuang shenzangbing zazhi, 2019 As an essential messenger between bones and vessel axis,sclerostin plays a key role in development and progression of vascular calcification;however,its mechanism is complicated.Current studies have demonstrated,sclerostin is an osteocyte-specific ...
PENG Qiong-yao, LIU Ling
doaj