Results 111 to 120 of about 13,466 (213)

Association of serum sclerostin with bone sclerostin in chronic kidney disease is lost in glucocorticoid treated patients

, 2019
: The osteocytic protein sclerostin inhibits bone turnover. Serum sclerostin rises early in chronic kidney disease (CKD), but if this reflects osteocyte sclerostin production is unclear, since sclerostin is also expressed in extra-skeletal tissue ...
Lindholm, Bengt, Stenvinkel, Peter, d' Haese, Patrick C., Behets, Geert, Haarhaus, Mathias, Boltenst\ue5l, Hendrik, Qureshi, Abdul Rashid   +6 more
core  

B4GALNT3 regulates glycosylation of sclerostin and bone mass

, 2023
Summary Background: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene is ...
Lerner, U. H. (Ulf H.), Movérare-Skrtic, S. (Sofia), Horkeby, K. (Karin), Luong, T. T. (Trang Thi Doan), Koskela, A. (Antti), Wu, J. (Jianyao), Nethander, M. (Maria), Nilsson, K. H. (Karin H.), Li, L. (Lei), Voelkl, J. (Jakob), Henning, P. (Petra), Alesutan, I. (Ioana), Tuukkanen, J. (Juha), Ohlsson, C. (Claes), Lagerquist, M. K. (Marie K.), Tobias, J. H. (Jon H.)   +15 more
core  

Sclerostin levels in patients with acromegaly

Endokrynologia Polska
Acromegaly is a rare, endocrine condition characterized by autonomous excessive secretion of growth hormone, causing numerous complications, including impairment of bone microarchitecture. The increased bone turnover observed in acromegaly can lead to bone fragility and elevated risk of vertebral fractures despite normal bone mineral density measured ...
Arnika, Wydra, Jakub, Wydra, Jagoda, Rogowska, Wojciech, Zgliczyński, Izabella, Czajka-Oraniec   +4 more
openaire   +2 more sources

Sclerostin : another vascular calcification inhibitor?

, 2013
: Context: Sclerostin, a Wnt antagonist produced by osteocytes, regulates osteoblast activity and is a well-established key player in bone turnover. Recent data indicate that the Wnt pathway may also be involved in vascular calcification.
Meijers, Bj\uf6rn, d' Haese, Patrick C., Claes, Kathleen J., Viaene, Liesbeth, Evenepoel, Pieter, Heye, Sam   +5 more
core  

Sclerostin in mineralized matrices and van Buchem disease

, 2009
Sclerostin is an inhibitor of bone formation expressed by osteocytes. We hypothesized that sclerostin is expressed by cells of the same origin and also embedded within mineralized matrices.
Oostenbroek, H.J., Hamersma, H., Gortzak, R. A., Van Hul, Wim, van Bezooijen, R.L., Hamdy, N.A.T., van Bezooijen, R. L., Van Hul, W., Bronckers, A. L., Papapoulos, S.E., Balemans, Wendy, Gortzak, R.A., Bronckers, A.L., Löwik, C.W.G.M., Lowik, C. W. G. M., Hogendoorn, P.C.W., Balemans, W., Hogendoorn, P. C. W., Hamdy, N. A. T., Dikkers, F.G., Papapoulos, S. E., van der Wee-Pals, L., Oostenbroek, H. J., Dikkers, F. G.   +23 more
core   +1 more source

Sclerostin serum levels in patients with systemic autoimmune diseases.

, 2016
Systemic autoimmune diseases (SADs) are associated with lower bone mass and an increased risk of fractures. Sclerostin has a pivotal role in bone metabolism.
Fernández-Roldán, Concepción, López-Mejías, Raquel, Robles, Concepción López, Mijares, Verónica, Callejas-Rubio, José Luis, González-Gay, Miguel Á, Ruiz, Manuela Expósito, Ortego Centeno, Norberto, Genre, Fernanda, Ubilla, Begoña, Fernández, Raquel Ríos, Cano, Daniel Sánchez   +11 more
core   +1 more source

Sclerostin and the Unloading of Bone [PDF]

Journal of Bone and Mineral Research, 2009
openaire   +2 more sources

Inhibition of Sclerostin function by antibodies.

, 2013
(A) Sclerostin-GFP was pre-incubated with Fc or the different Fabs raised against Sclerostin for 30 minutes at room temperature, next the mixtures were added to 293-LRP6 cells for 1.5h at 4°C.
Puck B. van Kasteren (408008), Maarten van Dinther (408002), Juan Zhang (48597), Verena Boschert (408004), Stella E. Weidauer (408003), Christian Frisch (237601), Thomas D. Mueller (240937), Eva-Maria Muth (408005), Achim Knappik (408006), David J. J. de Gorter (408007), Peter ten Dijke (82259)   +10 more
core   +1 more source

Progress of studies on sclerostin’s role in vascular calcification of chronic kidney disease

Linchuang shenzangbing zazhi, 2019
As an essential messenger between bones and vessel axis,sclerostin plays a key role in development and progression of vascular calcification;however,its mechanism is complicated.Current studies have demonstrated,sclerostin is an osteocyte-specific ...
PENG Qiong-yao, LIU Ling
doaj  

Serum sclerostin as a biomarker of disease activity in ankylosing spondylitis in correlation with radiographic imaging

Egyptian Rheumatology and Rehabilitation
Background The wingless signaling pathway of bone development is inhibited by sclerostin, which may contribute to the etiology of ankylosing spondylitis.
Nouran Medhat Abd El Samad Sakrana, Nevine Mohamed ElSayed Badr, Manar Ahmed Azab Hassan, Marwa Ahmed Kamel Hassan   +3 more
doaj   +1 more source