Results 91 to 100 of about 13,851 (214)

S100A9 Induces RANKL Expression in Osteocytes Utilizing IL‐6/sIL‐6R Combination and gp130 Signaling Pathways

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
S100A9 promotes osteocyte–macrophage crosstalk by inducing osteocyte‐derived IL‐6 and macrophage‐derived soluble IL‐6 receptor (sIL‐6R). The IL‐6/sIL‐6R complex activates gp130–JAK1–STAT3 signaling in osteocytes, enhancing RANKL expression and RANK‐mediated osteoclastogenesis.
Eijiro Sakamoto, Tetsuya Yoshimoto, Rie Kido, Mikihito Kajiya, Hiromichi Yumoto   +4 more
wiley   +1 more source

Sclerostin and occlusion: A brief review

Journal of Indian Society of Periodontology, 2015
In its pursuit of understanding the wonders of human body, mankind has stumbled upon yet another discovery which not only is a key to chest of unanswered queries but also opens a plethora of new possibilities. Till recently the osteocytes were considered latent cells merely entrapped in the matrix of bone. With the discovery of beta-catenin pathway and
Pankaj Bansal, Pritma Singh, Afshan Bey, Narinder Dev Gupta   +3 more
openaire   +3 more sources

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, Volume 13, Issue 57, 14 October 2026.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Sclerostin Blood Levels Before and After Kidney Transplantation

Kidney & Blood Pressure Research, 2014
Background/Aims: Sclerostin is secreted by osteocytes. As a circulating inhibitor of the Wnt-signaling pathway it inhibits bone formation and contributes to the development of osteoporosis.
Marco Bonani, Daniel Rodriguez, Thomas Fehr, Nilufar Mohebbi, Jens Brockmann, Markus Blum, Nicole Graf, Diana Frey, Rudolf P. Wüthrich   +8 more
doaj   +1 more source

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 7, October 2026.
Exercise activates skeletal muscle to release myokines (irisin, acute IL‐6, IL‐15 and BAIBA) and suppress myostatin, which may help counteract T2DM‐induced hyperglycemia, AGE accumulation, chronic inflammation and osteoimmune imbalance, potentially contributing to improved bone quality and reduced fracture risk.
Chao Wu, Jun Zou, Yu Yuan
wiley   +1 more source

Role of sclerostin in mastocytosis bone disease

Scientific Reports
Mastocytosis is a heterogeneous group of disorders, characterized by accumulation of clonal mast cells which can infiltrate several organs, most often spine (70%). The pathogenesis of mastocytosis bone disease is poorly understood.
Aneta Szudy-Szczyrek, Radosław Mlak, Dominika Pigoń-Zając, Witold Krupski, Marcin Mazurek, Aleksandra Tomczak, Karolina Chromik, Aleksandra Górska, Paweł Koźlik, Adrian Juda, Anna Kokoć, Maciej Dubaj, Tomasz Sacha, Marek Niedoszytko, Grzegorz Helbig, Michał Szczyrek, Justyna Szumiło, Teresa Małecka-Massalska, Marek Hus   +18 more
doaj   +1 more source

Sclerostin and Wnt Signaling in Idiopathic Juvenile Osteoporosis Using High-Resolution Confocal Microscopy for Three-Dimensional Analyses

Children
Background: Idiopathic juvenile osteoporosis (IJO) is a rare condition characterized by low bone mass that can increase the risk of fractures in children.
Renata C. Pereira, Kathleen J. Noche, Barbara Gales, Zhangying Chen, Isidro B. Salusky, Lauren V. Albrecht   +5 more
doaj   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol

, 2018
Qun Cheng,1–3 Xiaoxing Wu,1,2 Yanping Du,1–3 Wei Hong,1–3 Wenjing Tang,1–3 Huilin Li,1–3 Minmin Chen,1–3 Songbai Zheng3 1Department of Osteoporosis and Bone Disease, Huadong Hospital Affiliated to Fudan University ...
Li H, Cheng Q, Chen M, Zheng S, Du Y, Hong W, Tang W, Wu X   +7 more
core  

Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy

, 2021
Among the different effects of bariatric surgery, here we focus on bone-derived inflammatory molecules, and in particular, sclerostin; an osteocyte product potentially associated with cardio-metabolic diseases.
Ministrini S., Carbone F., Montecucco F., Migliola E. N., De Vuono S., Ricci M. A., Boni M., Bonaventura A., Vaudo G., Vecchie A., Lupattelli G., Fabrizio Montecucco, Montecucco, F., Graziana Lupattelli, Stefano De Vuono, Vaudo, G., Carbone, F., De Vuono, S., Alessandra Vecchié, Vecchié, A., Migliola, E. N., Ministrini, S., Aldo Bonaventura, Bonaventura, A., Ricci, M. A., Boni, M., Stefano Ministrini, Maria Anastasia Ricci, Marcello Boni, Lupattelli, G., Federico Carbone, Gaetano Vaudo, Elisa Nulli Migliola   +32 more
core   +1 more source