Results 91 to 100 of about 13,466 (213)

Circulating levels of sclerostin predict glycemic improvement after sleeve gastrectomy

, 2021
Among the different effects of bariatric surgery, here we focus on bone-derived inflammatory molecules, and in particular, sclerostin; an osteocyte product potentially associated with cardio-metabolic diseases.
Ministrini S., Carbone F., Montecucco F., Migliola E. N., De Vuono S., Ricci M. A., Boni M., Bonaventura A., Vaudo G., Vecchie A., Lupattelli G.   +10 more
core   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol

, 2018
Qun Cheng,1–3 Xiaoxing Wu,1,2 Yanping Du,1–3 Wei Hong,1–3 Wenjing Tang,1–3 Huilin Li,1–3 Minmin Chen,1–3 Songbai Zheng3 1Department of Osteoporosis and Bone Disease, Huadong Hospital Affiliated to Fudan University ...
Li H, Cheng Q, Chen M, Zheng S, Du Y, Hong W, Tang W, Wu X   +7 more
core  

Serum Sclerostin Increases After Acute Physical Activity

, 2017
International audiencePhysical activity has a major impact on bone density and on osteoporosis prevention. Sclerostin is produced by osteocytes and inhibits bone formation. The impact of exercise on sclerostin secretion has not been studied so far.
Sornay-Rendu, E., Cyrille B. Confavreux, Marie-Eva Pickering, Confavreux, C. B., Pickering, M. E., Pawel Szulc, Karim Chikh, Simon, M., Carlier, M. C., Marie Simon, Elisabeth Sornay-Rendu, Raby, A. L., Szulc, P., Chikh, Karim, Marie-Christine Carlier, Anne-Lise Raby   +15 more
core   +1 more source

Role of sclerostin in mastocytosis bone disease

Scientific Reports
Mastocytosis is a heterogeneous group of disorders, characterized by accumulation of clonal mast cells which can infiltrate several organs, most often spine (70%). The pathogenesis of mastocytosis bone disease is poorly understood.
Aneta Szudy-Szczyrek, Radosław Mlak, Dominika Pigoń-Zając, Witold Krupski, Marcin Mazurek, Aleksandra Tomczak, Karolina Chromik, Aleksandra Górska, Paweł Koźlik, Adrian Juda, Anna Kokoć, Maciej Dubaj, Tomasz Sacha, Marek Niedoszytko, Grzegorz Helbig, Michał Szczyrek, Justyna Szumiło, Teresa Małecka-Massalska, Marek Hus   +18 more
doaj   +1 more source

Sclerostin and Wnt Signaling in Idiopathic Juvenile Osteoporosis Using High-Resolution Confocal Microscopy for Three-Dimensional Analyses

Children
Background: Idiopathic juvenile osteoporosis (IJO) is a rare condition characterized by low bone mass that can increase the risk of fractures in children.
Renata C. Pereira, Kathleen J. Noche, Barbara Gales, Zhangying Chen, Isidro B. Salusky, Lauren V. Albrecht   +5 more
doaj   +1 more source

The Health Benefits of Exercise: Molecular and Cellular Mechanisms

MedComm, Volume 7, Issue 9, September 2026.
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying, Huilin Wang, Xiu Lu, Wenjuan Zhang, Zhehao Lin, Kai Wang, Shangxuan Li, Lu Chen, Mingchao Jiang, Sarkawt Hamad, Yi Wang, Jianmin Wu, Shukuan Ling   +12 more
wiley   +1 more source

Epitranscriptomic Regulation of Bone Metabolism: Emerging Roles of N6‐Methyladenosine (m6A) Modification in Skeletal Homeostasis

Oral Science International, Volume 23, Issue 3, September 2026.
ABSTRACT N6‐methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic RNA and a central mechanism of epitranscriptomic gene regulation. Although m6A was first characterized in messenger RNA (mRNA), it is also deposited on ribosomal RNA (rRNA), circular RNA, and other RNA species, where it regulates RNA stability, decay ...
Shoichiro Kokabu, Quan Yuan
wiley   +1 more source

Load-sensitive Sclerostin regulation requires TGFβ signaling.

, 2013
Immunohistochemistry shows reduced Sclerostin expression between the loaded and nonloaded tibiae of WT mice, but no difference in Sclerostin expression in tibiae of DNTβRII mice (A).
Tamara Alliston (265049), Jacqueline Nguyen (290539), Daniel Nguyen (290542), Simon Y. Tang (290540)   +3 more
core   +1 more source

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Aging Cell, Volume 25, Issue 9, September 2026.
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong‐en Wang, Qianjin Guo, You Zhang, Jiawei Wu, Huiyun Xu   +10 more
wiley   +1 more source