Results 131 to 140 of about 11,659 (170)

Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bone. [PDF]

JBMR Plus
Yamashita A, Tenshin H, Matsuki S, Nishino G, Ser-Od S, Saito FM, Hiasa M, Tanaka E.   +7 more
europepmc   +1 more source

Editorial: Osteocytes in bone health and beyond. [PDF]

Front Cell Dev Biol
Qin L, Ruan YC, Jing D, Acosta FM.
europepmc   +1 more source

Effect of Orthodontic Tooth Movement on Sclerostin Expression in Alveolar Bone Matrix: A Systematic Review of Studies on Animal Models. [PDF]

Dent J (Basel)
Rogers ML, Rossouw PE, Javed F.
europepmc   +1 more source

Anabolics in Cancer Patients: To Use or Not to Use? [PDF]

Endocrinol Metab (Seoul)
Hong AR.
europepmc   +1 more source

Drug discovery of sclerostin inhibitors

Acta Pharmaceutica Sinica B, 2022
Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases.
Meiheng Sun, Huan Xiao, Zongkang Zhang   +2 more
exaly   +4 more sources

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Sclerostin deficiency in humans

Bone, 2017
Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a better understanding of the role of ...
Lierop, A.H. van, Appelman-Dijkstra, N.M., Papapoulos, S.E.   +2 more
openaire   +3 more sources

Sclerostin and skeletal health

Reviews in Endocrine and Metabolic Disorders, 2015
Sclerostin is a cysteine-knot glycoprotein product of the SOST gene, predominately expressed by osteocytes, that is a regulator of osteoblastic bone formation. When sclerostin binds to its low-density lipoprotein receptor-related proteins 5 and 6 on the cell membrane of osteoblasts, it inhibits canonical Wnt/β-catenin signaling and reduces osteoblastic
Maryam, Sharifi, Lisa, Ereifej, E Michael, Lewiecki   +2 more
openaire   +2 more sources

Sclerostin

Current Opinion in Endocrinology, Diabetes & Obesity, 2014
Discovery of the Wnt signaling pathway and understanding the central role of osteocyte in skeletal homeostasis have been the major advances in skeletal biology over the past decade. Sclerostin, secreted mainly (but not exclusively) by osteocytes, has emerged as a key player in skeletal homeostasis.
Mahalakshmi, Honasoge, Ajay D, Rao, Sudhaker D, Rao   +2 more
openaire   +2 more sources

Sclerostin: from bench to bedside

Journal of Bone and Mineral Metabolism, 2020
Skeletal integrity is maintained by a meticulous balance between bone resorption and bone formation, and recent studies have revealed the essential role of canonical Wnt signaling pathways in maintaining skeletal homeostasis. The SOST gene, which encodes sclerostin, a member of Dan family glycoproteins, was originally identified as the gene responsible
Sakae Tanaka, Toshio Matsumoto
openaire   +2 more sources