Results 51 to 60 of about 38,030 (279)
NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression
Redox Biology, 2021 Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a process in which they are embedded in an osteoid. We previously showed that nutrient restriction promotes the osteocyte transcriptional program and is associated with ...
Cristina Sánchez-de-Diego +8 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Phenotypical changes of osteocytes in osteoarthritis [PDF]
, 2014 This thesis focuses on the role of a bone cell, osteocytes in the progression of osteoarthritis. The biological relevance of this study has opened doors to new possibilities of understanding the pathogenesis of ...
Tumkur Jaiprakash, Anjali
core
Roles of osteocytes in phosphate metabolism
Frontiers in Endocrinology, 2022 Osteocytes are dendritic cells in the mineralized bone matrix that descend from osteoblasts. They play critical roles in controlling bone mass through the production of sclerostin, an inhibitor of bone formation, and receptor activator of nuclear factor ...
Toshimi Michigami
doaj +1 more source
Osteocytes and Bone Metastasis [PDF]
Frontiers in Endocrinology, 2020 Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of the most common sites of metastasis for many solid tumors. Once cancer cells colonize in the bone, it imposes a major clinical challenge for the treatment of the disease, and fatality rates increase drastically.
Manuel A. Riquelme +2 more
openaire +3 more sources
Advanced Materials, EarlyView.Combined 2D and 3D X‐ray scattering imaging is used to analyse nanostructural properties in the inferior and superior cortex of 78 human femoral necks from 44 donors. The methodology allows for increased interpretation of nanostructure in a statistically relevant dataset, revealing nanostructural differences in anatomical locations critical to clinical
Torne Tänzer +8 more
wiley +1 more source
Research progress on the relationship between osteocytes and periodontitis
口腔疾病防治, 2020 Osteocytes, which develop from osteoblasts, are recognized as the main cells embedded in mature bone tissue. The traditional notion is that osteocytes exclusively play a structural role, however, with the development of related research in recent years ...
ZHU Xuanzhi +3 more
doaj +1 more source
Advanced Science, 2023 As major regulators on bone formation/resorption in response to mechanical stimuli, osteocytes have shown great promise for restoring bone injury. However, due to the unmanageable and unabiding cell functions in unloading or diseased environments, the ...
Liyuan Zheng +10 more
doaj +1 more source
Advanced Science, EarlyView.This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer +17 more
wiley +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source