Results 71 to 80 of about 38,030 (279)

Bone as a source of organism vitality and regeneration

Folia Histochemica et Cytobiologica, 2012
The most important features that determine the vital role of bone include: a) a continuous supply of calcium, which is indispensible for every cell of the entire organism at all times, and b) the delivery of circulating blood cells and some adult stem ...
Jolanta Kowalewska, Wiesława Ewa Niklińska, Zygmunt Mackiewicz, Lech Chyczewski   +3 more
doaj   +1 more source

Connexin 43 hemichannels regulate mitochondrial ATP generation, mobilization, and mitochondrial homeostasis against oxidative stress

eLife, 2022
Oxidative stress is a major risk factor that causes osteocyte cell death and bone loss. Prior studies primarily focus on the function of cell surface expressed Cx43 channels.
Jingruo Zhang, Manuel A Riquelme, Rui Hua, Francisca M Acosta, Sumin Gu, Jean X Jiang   +5 more
doaj   +1 more source

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

Advanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu, Gewei Yan, Zhentao She, Yingzhu He, Kangqi Liu, Jianan Qu   +5 more
wiley   +1 more source

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone [PDF]

, 2019
Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until bone is remodeled. The interconnected osteocyte network within the
Bambery, Keith R, Mackie, Eleanor J, Mackie, Eleanor J., Nguyen, H, Crimeen-Irwinl, B, Oakhill, JS, Crimeen-Irwinl, Blessing, Dite, Toby A., Tobin, MJ, Oakhill, Jonathan S, Forwood, Mark R, Martin, T. John, Sims, NA, Forwood, Mark R., Ikegame, Mika, Bambery, Keith R., Bambery, KR, Petibois, Cyril, Tobin, Mark J., Ansari, Niloufar, Smyth, Gordon K, Vrahnas, C, Huynh, N, Sims, Natalie A., Hu, Y, Forwood, MR, Huynh, Nguyen, Oakhill, Jonathan S., Tatarczuch, Liliana, Ansari, N, Hu, Yifang, Smyth, Gordon K., Crimeen-Irwin, Blessing, Sims, Natalie A, Martin, T John, Blank, M, Tobin, Mark J, Ikegame, M, Crimeen-Irwin, B, Blank, Martha, Vrahnas, Christina, Dite, TA, Martin, TJ, Smyth, GK, Nguyen, Huynh, Mackie, EJ, Petibois, C, Dite, Toby A, Tatarczuch, L   +48 more
core   +1 more source

Osteocyte Signaling in Bone [PDF]

Current Osteoporosis Reports, 2012
Osteocytes, the cells residing within the bone matrix and comprising 90% to 95% of the all bone cells, have long been considered quiescent bystander cells compared to the osteoblasts and osteoclasts whose activities cause bone gain and loss, and whose dysfunction lead to growth defects and osteoporosis. However, recent studies show that osteocytes play
Mitchell B, Schaffler, Oran D, Kennedy
openaire   +2 more sources

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Mechanical Loading Induces NRF2 Nuclear Translocation to Epigenetically Remodel Oxidative Stress Defense in Osteocytes

Antioxidants
The mechano-responsiveness of osteocytes is critical for maintaining bone health and associated with a reduced oxidative stress defense, yet the precise molecular mechanisms remain incompletely understood.
Yue Guo, Jing Zhang, Luyu Gong, Na Liu, Qiaoqiao Liu, Zhaojun Liu, Baosheng Guo, Jingping Yang   +7 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Differential distribution of microtubules in immature osteocytes in vivo [PDF]

, 2018
Objectives: The transition from osteoblasts to osteocytes is associated with dramatic changes in the cytoskeleton. We previously showed that the formation of osteoblast cell processes in 3D culture is microtubule dependent.
Takano-Yamamoto, T., Murshid, S. A., Kamioka, H.   +2 more
core   +1 more source

Effects of Cyclic Hydraulic Pressure on Osteocytes [PDF]

, 2011
Bone changes composition and structure to adapt to its mechanical environment. Osteocytes are putative mechanosensors responsible for orchestrating the bone remodeling process.
Liu, Chao
core   +3 more sources