Results 1 to 10 of about 14,683 (114)

Insights into taurine therapy for periodontitis: Targeting osteocyte ferroptosis to mitigate obesity-exacerbated bone damage [PDF]

Redox Biology
Obesity is a major systemic risk factor for periodontitis and is associated with increased alveolar bone destruction. However, the mechanisms by which obesity-related metabolic stress aggravates periodontal bone loss remain poorly understood.
Xin-Ge Chen, Xiao-Xue Zhu, Cui-Hua Cao, Yu-Zhe Chen, Yi-Ding Huo, Dian Gan, Dao-Kun Deng, Mei Xu, Hong-Lei Qu, Fa-Ming Chen, Bei-Min Tian, Xuan Li   +11 more
doaj   +2 more sources

Rethinking osteocyte models in vitro: the need for mineralised extracellular matrix and network architecture [PDF]

Frontiers in Bioengineering and Biotechnology
Osteocytes inhabit one of the most extreme cellular microenvironments in the human body: a hydrated, hierarchically structured mineralised extracellular matrix where lacunar confinement, canalicular connectivity, fluid transport and mechanics are ...
Małgorzata Morenc, Małgorzata Morenc, Flavia Medeiros Savi, Flavia Medeiros Savi, Alexandra Tits, Alexandra Tits, Pascal R. Buenzli, Pascal R. Buenzli, Richard Weinkamer, Richard Weinkamer, Peter Fratzl, Peter Fratzl, Nathalie Bock, Nathalie Bock, Nathalie Bock   +14 more
doaj   +2 more sources

Fibroblast growth factor receptor signaling in maturing osteoblasts controls cell-matrix interactions critical for osteocyte survival [PDF]

Bone Research
The terminal differentiation of osteoblasts into osteocytes, the most abundant cell type in cortical bone, is critical for skeletal homeostasis. Osteocyte loss is a hallmark of bone aging and fragility, yet the mechanisms regulating osteocyte formation ...
Debabrata Patra, Craig Smith, Chenming Wei, Courtney M. Mazur, Ilemona Ameadaji, Tiandao Li, Marc N. Wein, Matthew J. Silva, David M. Ornitz   +8 more
doaj   +2 more sources

Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice

Journal of Orthopaedic Translation, 2023
Background: Cell culture studies demonstrate the importance of β3 integrin in osteocyte mechanotransduction. However, the in vivo roles of osteocyte β3 integrin in the regulation of bone homeostasis and mechanotransduction are poorly defined.
Lei Qin, Dazhi Yang, Tailin He
exaly   +3 more sources

CFTR mediates Cl- transport in osteocytes to sustain cell viability and skeletal homeostasis [PDF]

Nature Communications
Osteocytes are long-lived with underlying mechanisms largely unknown. Here, we report that osteocyte-specific knockout of cystic fibrosis transmembrane conductance regulator (CFTR) results in excessive osteocyte death, proinflammatory cytokine surge ...
Peijie Hu, Wanting Du, Muyan Chu, Junjiang Chen, Xiaotian Zhang, Ziyi Chen, Jun Hu, Lei Qin, Wayne Yuk-Wai Lee, Jinghui Guo, Hui Chen, Ruiyao Xu, Xiaojun Cai, Xiaohua Jiang, Hsiao Chang Chan, Ling Qin, Jiankun Xu, Ye Chun Ruan   +17 more
doaj   +2 more sources

Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles [PDF]

Bone Research
During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive.
Xin Liu, Huiwen Zheng, Aochen Wang, Jianing Liu, Zhi Chen, Yiping Chen, Guobin Yang, Di Chen, Yufeng Zhang, Guohua Yuan   +9 more
doaj   +2 more sources

Morphometric Changes of Osteocyte Lacunar in Diabetic Pig Mandibular Cancellous Bone

Biomolecules, 2022
Osteocytes play an important role in bone metabolism. The interactions of osteocytes with the surrounding microenvironment can alter cellular and lacunar morphological changes.
Sheng Yao, Zhibin Du, Lan Xiao, Fuhua Yan, Saso Ivanovski, Yin Xiao   +5 more
doaj   +1 more source

Saos‐2 cells cultured under hypoxia rapidly differentiate to an osteocyte‐like stage and support intracellular infection by Staphylococcus aureus

Physiological Reports, 2023
The intracellular infection of osteocytes represents a clinically important aspect of osteomyelitis. However, few human osteocyte in vitro models exist and the differentiation of immature osteoblasts to an osteocyte stage typically takes at least 4‐weeks
Anja R. Zelmer, Yolandi Starczak, Lucian B. Solomon, Katharina Richter, Dongqing Yang, Gerald J. Atkins   +5 more
doaj   +1 more source

Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy

iScience, 2022
Summary: Glucocorticoid excess suppresses osteocyte remodeling of surrounding bone minerals, causes apoptosis of osteoblasts and osteocytes, and disrupts bone remodeling, eventually, leading to glucocorticoid-induced osteoporosis and bone fragility ...
Courtney M. Mazur, Christian D. Castro Andrade, Nicha Tokavanich, Tadatoshi Sato, Michael Bruce, Daniel J. Brooks, Mary L. Bouxsein, Jialiang S. Wang, Marc N. Wein   +8 more
doaj   +1 more source

Bundling of collagen fibrils influences osteocyte network formation during bone modeling

Scientific Reports, 2023
Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism.
Mana Hashimoto, Haruka Takahashi, Kaori Tabata-Okubo, Noriyuki Nagaoka, Kazuaki Tokunaga, Haruka Matsumori, Yoshihito Ishihara, Masaru Kaku, Tadahiro Iimura, Toru Hara, Hiroshi Kamioka   +10 more
doaj   +1 more source