Results 1 to 10 of about 13,327 (118)
Osteocytes and Weightlessness [PDF]
Current Osteoporosis Reports, 2021 Abstract Purpose of Review Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions ...
Iandolo, Donata +3 more
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Osteocyte Mechanobiology [PDF]
Current Osteoporosis Reports, 2017 Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells.Whereas increased mechanical forces promote bone formation ...
Yuhei, Uda +4 more
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Current Osteoporosis Reports, 2023 Abstract Purpose of Review The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing. Recent Findings Osteocytes are thought to be the primary mechanosensing cells in bone tissue ...
Verbruggen, S.W. +2 more
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Bone, 2013 Apoptotic death of osteocytes was recognized over 15 years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen deficiency and perhaps in other ...
Robert L, Jilka +2 more
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Journal of Bone and Mineral Research, 2010 Abstract The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity ...
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Aging, Osteocytes, and Mechanotransduction [PDF]
Current Osteoporosis Reports, 2017 The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging ...
Hemmatian, Haniyeh +3 more
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Isolation and purification of osteocytes [PDF]
Journal of Bone and Mineral Research, 1992 Abstract An isolation method for osteocytes is described. After removal of the periostea, bone cells were isolated from calvariae of 18-day-old chicken embryos by alternating treatments with collagenase and EDTA. Osteocytes were purified from the heterogeneous bone cell population with the help of the osteocyte-specific MAb OB 7.3 bound ...
A, van der Plas, P J, Nijweide
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The Effect of Osteocyte Signalling on Osteocyte Apoptosis [PDF]
Proceedings of Surabaya International Physiology Seminar, 2017 Abstract: Background: Physical exercise has been known that is one of the ways to evoke mechanical stimulation that can cause the change of the “strain”. The “strain” itself allows the converted mechanical signal to be a biochemistry that can produce a biological response to bone cells.
Dwi Setiani Sumardiko +2 more
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Osteocyte Cellular Senescence [PDF]
Current Osteoporosis Reports, 2020 Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.Numerous studies have established that senescent osteocytes accumulate in ...
Joshua N. Farr +3 more
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Osteocytes and Bone Metastasis [PDF]
Frontiers in Endocrinology, 2020 Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of the most common sites of metastasis for many solid tumors. Once cancer cells colonize in the bone, it imposes a major clinical challenge for the treatment of the disease, and fatality rates increase drastically.
Manuel A. Riquelme +2 more
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