Extracellular matrix mineralization promotes E11/gp38 glycoprotein expression and drives osteocytic differentiation. [PDF]
PLoS ONE, 2012 Osteocytes are terminally differentiated osteoblasts which reside in a mineralized extracellular matrix (ECM). The factors that regulate this differentiation process are unknown.
Matthew Prideaux +3 more
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Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis
Bone Research, 2022 Diabetic osteoporosis (DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we
Yiqi Yang, Yixuan Lin, Minqi Wang
exaly +2 more sources
Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice
Journal of Orthopaedic Translation, 2023 Background: Cell culture studies demonstrate the importance of β3 integrin in osteocyte mechanotransduction. However, the in vivo roles of osteocyte β3 integrin in the regulation of bone homeostasis and mechanotransduction are poorly defined.
Lei Qin, Tailin He, Guozhi Xiao
exaly +3 more sources
Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y
Advanced Science, 2021 A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age‐ and menopause‐associated bone loss and marrow adiposity.
Chun-Yuan Chen, Yi-Wei Liu, Kun Xia
exaly +2 more sources
Deep learning models to map osteocyte networks from confocal microscopy can successfully distinguish between young and aged bone. [PDF]
PLoS Computational BiologyOsteocytes, the most abundant and mechanosensitive cells in bone tissue, play a pivotal role in bone homeostasis and mechano-responsiveness, orchestrating the delicate balance between bone formation and resorption under daily activity. Studying osteocyte
Simon D Vetter +4 more
doaj +2 more sources
The influence of titanium particles on the functionality of osteocytes in bone remodeling: An In-vitro study. [PDF]
PLoS ONEBone remodeling is a tightly controlled process coordinated by osteocytes, which regulate both bone formation by osteoblasts and bone resorption by osteoclasts.
Neibal Almabrok +4 more
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Depletion of mmu-miR-185 enhances osteocyte connectivity and suppresses bone fragility through the interaction between ARL8B and RAB5A [PDF]
Stem Cell Research & TherapyBackground Osteocytes, the most abundant cells embedded in bone, possess extensive cytoplasmic extensions that form a complex network facilitating direct communication among osteocytes and with other effector cells in the bone and bone marrow.
Yaqi Cui +8 more
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Morphometric Changes of Osteocyte Lacunar in Diabetic Pig Mandibular Cancellous Bone
Biomolecules, 2022 Osteocytes play an important role in bone metabolism. The interactions of osteocytes with the surrounding microenvironment can alter cellular and lacunar morphological changes.
Sheng Yao +5 more
doaj +1 more source
iScience, 2022 Summary: Glucocorticoid excess suppresses osteocyte remodeling of surrounding bone minerals, causes apoptosis of osteoblasts and osteocytes, and disrupts bone remodeling, eventually, leading to glucocorticoid-induced osteoporosis and bone fragility ...
Courtney M. Mazur +8 more
doaj +1 more source
Physiological Reports, 2023 The intracellular infection of osteocytes represents a clinically important aspect of osteomyelitis. However, few human osteocyte in vitro models exist and the differentiation of immature osteoblasts to an osteocyte stage typically takes at least 4‐weeks
Anja R. Zelmer +5 more
doaj +1 more source