Results 41 to 50 of about 27,584 (206)
Aging, Osteocytes, and Mechanotransduction [PDF]
Current Osteoporosis Reports, 2017 The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging ...
Hemmatian, Haniyeh +3 more
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Scientific Reports, 2021 Osteocytes are mechanosensory commander cells to regulate bone remodeling throughout the lifespan. While the osteocytes are known as terminally differentiated cells derived from mesenchymal stem cells, the detailed mechanisms of osteocyte differentiation
Jeonghyun Kim, Taiji Adachi
doaj +1 more source
Utilizing osteocyte derived factors to enhance cell viability and osteogenic matrix deposition within IPN hydrogels [PDF]
, 2020 Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone the second most commonly ...
Hoey, David A. +2 more
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Osteocyte lacunar strain determination using multiscale finite element analysis
Bone Reports, 2020 Osteocytes are thought to be the primary mechanosensory cells within bone, regulating both osteoclasts and osteoblasts to control load induced changes in bone resorption and formation.
Sravan K. Kola +6 more
doaj +1 more source
Osteocytes Enhance Osteogenesis by Autophagy-Mediated FGF23 Secretion Under Mechanical Tension
Frontiers in Cell and Developmental Biology, 2022 Mechanical stimuli control cell behaviors that are crucial for bone tissue repair. Osteocytes sense extracellular mechanical stimuli then convert them into biochemical signals to harmonize bone remodeling.
Huiyue Xu +9 more
doaj +1 more source
The Small World of Osteocytes: Connectomics of the Lacuno-Canalicular Network in Bone
, 2017 Osteocytes and their cell processes reside in a large, interconnected network of voids pervading the mineralized bone matrix of most vertebrates. This osteocyte lacuno-canalicular network (OLCN) is believed to play important roles in mechanosensing ...
Fratzl, Peter +5 more
core +1 more source
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis
Bone ResearchOsteocytes are the main cells in mineralized bone tissue. Elevated osteocyte apoptosis has been observed in lytic bone lesions of patients with multiple myeloma. However, their precise contribution to bone metastasis remains unclear.
Yewei Jia +11 more
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The RIP1-RIP3 Complex Mediates Osteocyte Necroptosis after Ovariectomy in Rats. [PDF]
PLoS ONE, 2016 Osteocyte apoptosis has been reported to play a central role in bone remodeling. In addition to apoptosis, other mechanisms may be involved in osteocyte loss. This study aimed to investigate the effect of necroptosis on osteocytes in ovariectomized (OVX)
Hongwang Cui +2 more
doaj +1 more source
Mineral fabrication and golgi apparatus activity in the mouse calvarium [PDF]
, 2014 There is diverse opinion about the mechanism of bone mineralization with only intermittent reports of any direct organellar role played by the golgi apparatus (juxtanuclear body).
Aaron, Jean E. +2 more
core +1 more source
Osteocytes and Skeletal Pathophysiology [PDF]
Current Molecular Biology Reports, 2015 For many years, osteocytes have been the forgotten bone cells and considered as inactive spectators buried in the bone matrix. We now know that osteocytes detect and respond to mechanical and hormonal stimuli to coordinate bone resorption and bone formation.
Delgado-Calle, Jesus, Bellido, Teresita
openaire +2 more sources