Results 51 to 60 of about 27,584 (206)

Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice

BioTechniques, 2012
The purpose of this work was to establish a methodology to enable the isolation and study of osteocytes from skeletally mature young (4-month-old) and old (22-month-old) mice.
Amber Rath Stern, Matthew M. Stern, Mark E. Van Dyke, Katharina Jähn, Matthew Prideaux, Lynda F. Bonewald   +5 more
doaj   +1 more source

Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation

Bone Research
Osteogenesis imperfecta (OI) is a group of diseases caused by defects in type I collagen processing which result in skeletal fragility. While these disorders have been regarded as defects in osteoblast function, the role of matrix-embedded osteocytes in ...
Jialiang S. Wang, Katelyn Strauss, Caroline Houghton, Numa Islam, Sung-Hee Yoon, Tatsuya Kobayashi, Daniel J. Brooks, Mary L. Bouxsein, Yingshe Zhao, Cristal S. Yee, Tamara N. Alliston, Marc N. Wein   +11 more
doaj   +1 more source

Effect of Low-magnitude, High-frequency Vibration on Osteocytes in the Regulation of Osteoclasts [PDF]

, 2010
Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that
Al-Dujaili, Saja, Guenther, Axel, Lau, Esther, Liu, Dawei, Wang, Liyun, You, Lidan   +5 more
core   +2 more sources

Histologic and histomorphometric analysis of bone regeneration with bovine grafting material after 24 months of healing. A case report [PDF]

, 2018
Anorganic bovine bone mineral matrix (ABBMM) has been reported to have osteoconductive properties and no inflammatory or adverse responses when used as grafting material in sinus augmentation procedures.
Belleggia, Fabrizio, DeVillier, Patricia, Guarnieri, Renzo, Testarelli, Luca   +3 more
core   +1 more source

A systems biology approach to the identification and analysis of transcriptional regulatory networks in osteocytes

BMC Bioinformatics, 2009
Background The osteocyte is a type of cell that appears to be one of the key endocrine regulators of bone metabolism and a key responder to initiate bone formation and remodeling.
Harris Stephen E, Dean Angela K, Kalajzic Ivo, Ruan Jianhua   +3 more
doaj   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Osteocyte function, osteocyte death and bone fracture resistance

Molecular and Cellular Endocrinology, 2000
The function of the most numerous cell in bone, the osteocyte, has until recently been mysterious and at times controversial. There is now an emerging consensus that osteocytes modulate signals arising from mechanical loading and so direct the appearance and disappearance of bone tissue at the microscopic level, which allows bone as an organ both to ...
Noble, B, Reeve, J
openaire   +3 more sources

Osteocyte-specific dentin matrix protein 1: the role of mineralization regulation in low-magnitude high-frequency vibration enhanced osteoporotic fracture healing

Bone & Joint Research, 2022
Aims: There is an increasing concern of osteoporotic fractures in the ageing population. Low-magnitude high-frequency vibration (LMHFV) was shown to significantly enhance osteoporotic fracture healing through alteration of osteocyte lacuno-canalicular ...
Meng C. M. Li, Simon K-H. Chow, Ronald M. Y. Wong, Bailing Chen, Jack C. Y. Cheng, Ling Qin, Wing-Hoi Cheung   +6 more
doaj   +1 more source

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications.
Chantal Chenu, Guillaume Mabilleau, Iepsen, Iepsen, Marie Pereira   +4 more
core   +5 more sources

FGF23 production by osteocytes [PDF]

Pediatric Nephrology, 2012
Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease.
Lynda F, Bonewald, Michael J, Wacker
openaire   +2 more sources