Results 61 to 70 of about 27,584 (206)
Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice
Journal of Orthopaedic Translation, 2022 Background: The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely ...
Lei Qin +14 more
doaj +1 more source
Predicting cortical bone adaptation to axial loading in the mouse tibia [PDF]
, 2015 The development of predictive mathematical models can contribute to a deeper understanding of the specific stages of bone mechanobiology and the process by which bone adapts to mechanical forces.
A. A. Pitsillides +9 more
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Osteocyte Signaling in Bone [PDF]
Current Osteoporosis Reports, 2012 Osteocytes, the cells residing within the bone matrix and comprising 90% to 95% of the all bone cells, have long been considered quiescent bystander cells compared to the osteoblasts and osteoclasts whose activities cause bone gain and loss, and whose dysfunction lead to growth defects and osteoporosis. However, recent studies show that osteocytes play
Mitchell B, Schaffler, Oran D, Kennedy
openaire +2 more sources
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. [PDF]
, 2019 Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly associated with subchondral bone sclerosis. However, the cellular mechanisms responsible for changes to subchondral bone in OA, and the extent to which these ...
Acevedo, Claire +12 more
core
Bone Reports, 2018 Though osteoporosis is a significant cause of disability worldwide, treatment with pharmacologic agents decreases risk of fragility fracture. Though these treatments act through the bone remodeling system to improve bone mass, it is unclear if they alter
Amber Rath Stern +8 more
doaj +1 more source
JCI Insight, 2023 Osteocytes express parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptors and respond to the PTHrP analog abaloparatide (ABL) and to the PTH 1-34 fragment teriparatide (TPTD), which are used to treat osteoporosis.
Zhengtao Lv +10 more
doaj +1 more source
Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts [PDF]
, 2008 The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication.
Ishihara, Yoshihito +6 more
core +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2022 Background and Objectives: The ability of ovarian stem cells (OSCs) to differentiate into oocyte-like and theca cells may lead to major advances in infertility treatment.
Samane Adib
doaj
Kaelin Rapport - Histological Techniques for the Sex Determination of Skeletonized Human Remains [PDF]
, 2014 Determining the sex of skeletons is problematic in forensic and bio-archaeological research. Past studies demonstrate that bone cells can sometimes contain preserved sex chromosomal material in ancient samples. The sex chromosomes in skeletal remains may
Rapport, Kaelin
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Histological Analysis of Failed Cartilage Repair after Marrow Stimulation for the Treatment of Large Cartilage Defect in Medial Compartmental Osteoarthritis of the Knee [PDF]
, 2013 Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human ...
Abe, Nobuhiro +5 more
core +1 more source