Results 71 to 80 of about 27,584 (206)

Cyclic mechanical stretch contributes to network development of osteocyte-like cells with morphological change and autophagy promotion but without preferential cell alignment in rat

Biochemistry and Biophysics Reports, 2017
Osteocytes play important roles in controlling bone quality as well as preferential alignment of biological apatite c-axis/collagen fibers. However, the relationship between osteocytes and mechanical stress remains unclear due to the difficulty of three ...
Nao Inaba, Shinichiro Kuroshima, Yusuke Uto, Muneteru Sasaki, Takashi Sawase   +4 more
doaj   +1 more source

Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response [PDF]

, 2018
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to form bone or insufficient mechanical stimulus ...
A Carriero, A Moustafa, AF Pereira, AG Robling, AG Robling, AH Ng, AI Birkhold, AI Birkhold, AM Hanson, AM Weatherholt, B Javaheri, B Javaheri, B Javaheri, B Javaheri, B Kamal, BM Willie, C Liu, C Turner, CA Schneider, CH Turner, CT Rubin, DB Burr, DB Burr, DM Cullen, E Smith, ER Spector, EW Helge, F Bini, G Ducher, H Razi, J Wergedal, JR Mosley, JR Mosley, K Deere, K Deere, KC Lee, KE Poole, KJ Jepsen, LB Meakin, LE Lanyon, LE Lanyon, LE Lanyon, LE Lanyon, M Doube, M Schaffler, M Steiner, MD Brodt, MD Willinghamm, ME Lynch, MM Shimano, N Holguin, N Holguin, N Holguin, N Lara-Castillo, P Lind, P Sztefek, R DeSouza, RH Routh, RL Souza De, SM Millard, SM Ponik, T Jämsä, TC Lee, TK Patel, Y Umemura   +64 more
core   +4 more sources

MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts

Nature Communications, 2017
Control of osteocyte differentiation is not well understood. Here the authors show that the miR-23 cluster represses the TGF-β signalling repressor Prdm16 in osteoblasts, thus enhancing osteocyte differentiation and a low bone mass phenotype.
Huan-Chang Zeng, Yangjin Bae, Brian C. Dawson, Yuqing Chen, Terry Bertin, Elda Munivez, Philippe M. Campeau, Jianning Tao, Rui Chen, Brendan H. Lee   +9 more
doaj   +1 more source

The Effect of Osteocyte Signalling on Osteocyte Apoptosis [PDF]

Proceedings of Surabaya International Physiology Seminar, 2017
Abstract: Background: Physical exercise has been known that is one of the ways to evoke mechanical stimulation that can cause the change of the “strain”. The “strain” itself allows the converted mechanical signal to be a biochemistry that can produce a biological response to bone cells.
Dwi Setiani Sumardiko, Purwo Sri Rejeki, Gadis Meinar Sari   +2 more
openaire   +1 more source

Ptosis as a unique hallmark for autosomal recessive WNT1-associated osteogenesis imperfecta [PDF]

, 2019
Osteogenesis imperfecta (OI) is a heritable connective tissue disorder, mainly characterized by bone fragility and low bone mass. Defects in the type I procollagen-encoding genes account for the majority of OI, but increasingly more rare autosomal ...
Elcioglu, Nursel, Guillemyn, Brecht, Jagadeesh, Sujatha, Malfait, Fransiska, Nampoothiri, Sheela, Suresh, Beena, Symoens, Sofie, Turan, Serap, Yesodharan, Dhanya   +8 more
core   +1 more source

The Osteocyte: New Insights

Annual Review of Physiology, 2020
Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the osteocyte is perhaps among the least studied cells in all of vertebrate biology.
Robling, Alexander G., Bonewald, Lynda F.   +1 more
openaire   +3 more sources

Glucocorticoids and osteocyte autophagy [PDF]

Bone, 2013
Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases. While they are effective therapy, bone loss and incident fracture risk are high. While previous studies have found GC effects on both osteoclasts and osteoblasts, our work has focused on the effects of GCs on osteocytes.
Wei, Yao, Weiwei, Dai, Jean X, Jiang, Nancy E, Lane   +3 more
openaire   +2 more sources

How much do we know about the role of osteocytes in different phases of fracture healing? A systematic review

Journal of Orthopaedic Translation, 2020
Background: Although emerging studies have provided evidence that osteocytes are actively involved in fracture healing, there is a general lack of a detailed understanding of the mechanistic pathway, cellular events and expression of markers at different
Man Huen Victoria Choy, Ronald Man Yeung Wong, Simon Kwoon Ho Chow, Meng Chen Li, Yu Ning Chim, Tsz Kiu Li, Wing Tung Ho, Jack Chun Yiu Cheng, Wing Ho Cheung   +8 more
doaj   +1 more source

RAGE Signaling in Skeletal Biology [PDF]

, 2019
PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M., Essex, Alyson L., Plotkin, Lilian I.   +2 more
core   +2 more sources

Osteocyte control of osteoclastogenesis [PDF]

Bone, 2013
Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine
Charles A, O'Brien, Tomoki, Nakashima, Hiroshi, Takayanagi   +2 more
openaire   +2 more sources