Results 91 to 100 of about 27,584 (206)

A perfusion culture system for assessing bone marrow stromal cell differentiation on PLGA scaffolds for bone repair [PDF]

, 2018
Biomaterials development for bone repair is currently hindered by the lack of physiologically relevant in vitro testing systems. Here we describe the novel use of a bi-directional perfusion bioreactor to support the long term culture of human bone marrow
Alini, Mauro, Bara, Jennifer J, Bardsley, Katie, El Haj, Alicia J, Moser, Caroline, Stoddart, Martin J   +5 more
core   +2 more sources

Positioning novel biologicals in CKD-mineral and bone disorders [PDF]

, 2017
Renal osteodystrophy (ROD), the histologic bone lesions of chronic kidney disease (CKD), is now included in a wider syndrome with laboratory abnormalities of mineral metabolism and extra-skeletal calcifications or CKD-mineral and bone disorders (CKD-MBD),
Covic, Adrian, Mazzaferro, Sandro, Muci, MARIA LUISA, Pasquali, Marzia, Rotondi, Silverio, Tartaglione, Lida   +5 more
core   +1 more source

IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro

Cellular Physiology and Biochemistry, 2017
Background/Aims: Evidence suggests that IL-6 affects bone mass by modulating osteocyte communication towards osteoclasts. However, the mechanism by which IL-6 enhances osteocyte-mediated osteoclastogenesis is unclear.
Qing Wu, Xiaokang Zhou, Danqing Huang, Yingchen JI, Feiwu Kang   +4 more
doaj   +1 more source

Increased sclerostin associated with stress fracture of the third metacarpal bone in the Thoroughbred Racehorse [PDF]

, 2018
Objectives: The exact aetiopathogenesis of microdamage induced long bone fractures remains unknown. These fractures are likely the result of inadequate bone remodeling in response to damage.
Henson, F, Hopper, N, Singer, E
core   +2 more sources

Osteocyte necroptosis drives osteoclastogenesis and alveolar bone resorption during orthodontic tooth movement

Scientific Reports
Orthodontic tooth movement (OTM) has been described as a bone remodeling process mediated by the expression of various inflammatory cytokines, including tumor necrosis factor-α (TNF-α). Necroptosis is a form of regulated cell death that is mainly induced
Fumitoshi Ohori, Hideki Kitaura, Aseel Marahleh, Jinghan Ma, Mariko Miura, Jiayi Ren, Kohei Narita, Ziqiu Fan, Angyi Lin, Itaru Mizoguchi   +9 more
doaj   +1 more source

A novel model of in vitro osteocytogenesis induced by retinoic acid treatment [PDF]

European Cells & Materials, 2012
Despite recent research which more and more stresses the importance of osteocytes in regulating bone and systemic mineral metabolism, current molecular and functional knowledge of osteocyte properties are still incomplete, mostly due to limited ...
D Mattinzoli, P Messa, A Corbelli, M Ikehata, C Zennaro, S Armelloni, M Li, L Giardino, MP Rastaldi   +8 more
doaj  

The Emerging Role of Osteocytes in Cancer in Bone

JBMR Plus, 2019
Advances in the last decade have established the osteocyte, the most abundant cell in bone, as a dynamic and multifunctional cell capable of controlling bone homeostasis by regulating the function of both osteoblasts and osteoclasts.
Emily G Atkinson, Jesús Delgado‐Calle
doaj   +1 more source

Mechanical loading on osteocytes regulates thermogenesis homeostasis of brown adipose tissue by influencing osteocyte-derived exosomes

Journal of Orthopaedic Translation
Background: Osteocytes are the main stress-sensing cells in bone. The substances secreted by osteocytes under mechanical loading play a crucial role in maintaining body homeostasis.
Yuze Ma, Na Liu, Xiaoyan Shao, Tianshu Shi, Jiaquan Lin, Bin Liu, Tao Shen, Baosheng Guo, Qing Jiang   +8 more
doaj   +1 more source

Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D

Frontiers in Endocrinology
IntroductionChanges to bone physiology play a central role in the development of osteoarthritis with the mechanosensing osteocyte releasing factors that drive disease progression.
Sophie J. Gilbert, Ryan Jones, Ben J. Egan, Cleo Selina Bonnet, Sam L. Evans, Sam L. Evans, Deborah J. Mason   +6 more
doaj   +1 more source

From death to birth: how osteocyte death promotes osteoclast formation

Frontiers in Immunology
Bone remodeling is a dynamic and continuous process involving three components: bone formation mediated by osteoblasts, bone resorption mediated by osteoclasts, and bone formation-resorption balancing regulated by osteocytes. Excessive osteocyte death is
Weijie Zhao, Jiale Qian, Ji Li, Tian Su, Tian Su, Xiaozhong Deng, Yonghua Fu, Xuelong Liang, Hongwang Cui   +8 more
doaj   +1 more source