Results 101 to 110 of about 27,584 (206)

A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells

Advanced Science
Bone metastases are a common cause of suffering in breast and prostate cancer patients, however, the interaction between bone cells and cancer cells is poorly understood.
Stefaan W. Verbruggen, Joanne Nolan, Michael P. Duffy, Oliver M.T. Pearce, Christopher R. Jacobs, Martin M. Knight   +5 more
doaj   +1 more source

Osteocytes in the Metastatic Bone Niche: Mechanistic Pathways and Therapeutic Targets

Pharmaceuticals
Osteocytes, once viewed mainly as passive bone-embedded cells, are now recognized as active regulators of the metastatic bone niche. Emerging evidence indicates that these cells integrate mechanical, inflammatory, and tumor-derived cues to influence ...
Alhomam Dabaliz, Mohamad Bakir, Lana Fatash, Mais Aldoush, Khalid Said Mohammad   +4 more
doaj   +1 more source

Osteocytes Mechanosensing in NASA Rotating Wall Bioreactor [PDF]

, 2010
Osteocyte cells are the most abundant (90%) yet least understood bone cell type in the human body. Osteocytes are theorized to be the mechanosensors and transducers of mechanical load for bones, yet the biological mechanism of this action remains elusive.
Barry, Kevin, Bouxsein, Mary, Pajevic, Paola Divieti, Sibonga, Jean, Spatz, Jordan, Wu, Honglu   +5 more
core   +1 more source

β-arrestin/connexin 43 complex anchors ERKs outside the nucleus: a pre-requisite for bisphosphonate anti-apoptotic effect mediated by CX43/ERK in osteocytes [PDF]

, 2016
Bisphosphonates (BPs) anti-fracture ef cacy may be due in part to inhibition of osteocyte apoptosis. This effect requires opening of con- nexin (Cx) 43 hemichannels and phosphoryla- tion of the extracellular signal regulated kinases (ERKs).
Bellido, Teresita, Gortazar, Arancha R., Plotkin, Lilian I.   +2 more
core  

Osteocyte [PDF]

, 2020
openaire   +1 more source

Osteocyte Cell-Cell Communication Within and Beyond Bone. [PDF]

Curr Osteoporos Rep
Bakker AD, van Santen VJB.
europepmc   +1 more source

Bone tissue regeneration: role of osteocyte mechanosensing and mechanotransduction. [PDF]

Stem Cells Transl Med
Seddiqi H, Klein-Nulend J, Jin J.
europepmc   +1 more source

Osteocytes orchestrate browning: emerging signals in bone-fat crosstalk: a systematic review. [PDF]

Front Endocrinol (Lausanne)
Anees H, Jahed V, Sabouri Z, Jamous R, Pennisi CP, Heiss C, El Khassawna T.   +6 more
europepmc   +1 more source

Modulation of tocotrienol's bone effects by osteocytes: a perspective. [PDF]

Front Pharmacol
Zahanordin NN, Ng PY, Chin KY.
europepmc   +1 more source

Osteocyte-derived erythroferrone regulates liver hepcidin during stress erythropoiesis. [PDF]

Blood Adv
Myneni VD, Parashar A, Vitale-Cross L, Szalayova I, de Castro LF, Mezey E.   +5 more
europepmc   +1 more source