Results 11 to 20 of about 13,327 (118)
Osteocytes and Skeletal Pathophysiology [PDF]
Current Molecular Biology Reports, 2015 For many years, osteocytes have been the forgotten bone cells and considered as inactive spectators buried in the bone matrix. We now know that osteocytes detect and respond to mechanical and hormonal stimuli to coordinate bone resorption and bone formation.
Delgado-Calle, Jesus, Bellido, Teresita
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The Cementocyte—An Osteocyte Relative? [PDF]
Journal of Dental Research, 2016 Cementum is a mineralized tissue covering the tooth root that functions in tooth attachment and posteruptive adjustment of tooth position. During formation of the apically located cellular cementum, some cementoblasts become embedded in the cementoid matrix and become cementocytes. As apparently terminally differentiated cells embedded in a mineralized
N, Zhao, B L, Foster, L F, Bonewald
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Osteocyte Signaling in Bone [PDF]
Current Osteoporosis Reports, 2012 Osteocytes, the cells residing within the bone matrix and comprising 90% to 95% of the all bone cells, have long been considered quiescent bystander cells compared to the osteoblasts and osteoclasts whose activities cause bone gain and loss, and whose dysfunction lead to growth defects and osteoporosis. However, recent studies show that osteocytes play
Mitchell B, Schaffler, Oran D, Kennedy
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FGF23 production by osteocytes [PDF]
Pediatric Nephrology, 2012 Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease.
Lynda F, Bonewald, Michael J, Wacker
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Osteocyte function, osteocyte death and bone fracture resistance
Molecular and Cellular Endocrinology, 2000 The function of the most numerous cell in bone, the osteocyte, has until recently been mysterious and at times controversial. There is now an emerging consensus that osteocytes modulate signals arising from mechanical loading and so direct the appearance and disappearance of bone tissue at the microscopic level, which allows bone as an organ both to ...
Noble, B, Reeve, J
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Mechanosensation and transduction in osteocytes [PDF]
BoneKEy-Osteovision, 2006 There may be no single mechanoreceptor in osteocytes, but instead a combination of events that has to be triggered for mechanosensation and transduction of signal to occur. Possibilities include shear stress along dendritic processes and/or the cell body, cell deformation in response to strain, and primary cilia.
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Fluorescent mapping of osteocyte-driven bone formation at pre-osteocyte and mature osteocyte lacunae
Acta BiomaterialiaBone modeling and remodeling by osteoblasts and osteoclasts has been considered the primary mechanism of bone metabolism; however, osteocyte bone cells resorb their surrounding perilacunar bone matrix. It is unknown whether perilacunar remodeling contributes to bone formation in the absence of disease, disorder, or other external stimuli.
Sarah Ford +5 more
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Analysis and Imaging of Osteocytes
Journal of Visualized ExperimentsOsteocytes are the bone cells that are thought to respond to mechanical strains and fluid flow shear stress (FFSS) by activating various biological pathways in a process known as mechanotransduction. Confocal image-derived models of osteocyte networks are a valuable tool for conducting Computational Fluid Dynamics (CFD) analysis to evaluate shear ...
Mohammad, Niroobakhsh +5 more
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Establishment of artificial intelligence-driven fluorescence morphometry reveals involvement of osteocyte perilacunar remodeling specifically in mandibular bone of ovariectomized rats. [PDF]
Microscopy (Oxf)Nakanishi-Kimura A +4 more
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A mathematical model of osteocyte network control of bone mechanical adaptation. [PDF]
Biomech Model MechanobiolMehrpooya A, Challis VJ, Buenzli PR.
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