Results 11 to 20 of about 27,584 (206)
Osteocytes and Weightlessness [PDF]
Current Osteoporosis Reports, 2021 Abstract Purpose of Review Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions ...
Iandolo, Donata +3 more
openaire +4 more sources
Osteocyte Mechanobiology [PDF]
Current Osteoporosis Reports, 2017 Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells.Whereas increased mechanical forces promote bone formation ...
Yuhei, Uda +4 more
openaire +2 more sources
Bone, 2013 Apoptotic death of osteocytes was recognized over 15 years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen deficiency and perhaps in other ...
Robert L, Jilka +2 more
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The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]
, 2013 Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This
Ayati, Bruce P. +3 more
core +8 more sources
Bundling of collagen fibrils influences osteocyte network formation during bone modeling
Scientific Reports, 2023 Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism.
Mana Hashimoto +10 more
doaj +1 more source
Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone
Bone & Joint Research, 2022 Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA.
Jun Zhou +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 The activation of hypoxia-inducible factor 1α (HIF-1α) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures.
Kaizhe Chen +9 more
doaj +1 more source
Molecular Medicine, 2022 Background It is well-known that both macrophages and osteocytes are critical regulators of osteogenesis and osteoclastogenesis, yet there is limited understanding of the macrophage-osteocyte interaction, and how their crosstalk could affect bone ...
Shengfang Wang +5 more
doaj +1 more source
Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]
, 2014 The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes.
Buenzli, Pascal R
core +3 more sources
Osteocyte Cellular Senescence [PDF]
Current Osteoporosis Reports, 2020 Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.Numerous studies have established that senescent osteocytes accumulate in ...
Joshua N. Farr +3 more
openaire +2 more sources