Osteoblast-Osteoclast Communication and Bone Homeostasis [PDF]
Cells, 2020 Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell ...
Jung-Min Kim +4 more
doaj +4 more sources
Bone Morphogenetic Protein-2 in Development and Bone Homeostasis [PDF]
Journal of Developmental Biology, 2020 Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and ...
Daniel Halloran +2 more
doaj +3 more sources
Healthy bone tissue homeostasis [PDF]
Experimental and Molecular Medicine, 2020 Je-Yong Choi
doaj +3 more sources
Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target [PDF]
Frontiers in PharmacologyBone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of bone homeostasis can lead to the development of metabolic bone diseases such as osteoporosis and osteoarthritis.
Qian-Yun Ye +11 more
doaj +2 more sources
Current advances of bone homeostasis imbalance in the cause of hereditary metabolic bone diseases [PDF]
EFORT Open ReviewsBone homeostasis, a dynamic equilibrium essential for skeletal development and repair, is coordinately regulated by osteoclasts, osteoblasts, and osteocytes.
Xinyu Dai +4 more
doaj +2 more sources
Targeting the central and peripheral nervous system to regulate bone homeostasis: mechanisms and potential therapies [PDF]
Military Medical ResearchThe skeleton is innervated by different types of nerves and receives signaling from the nervous system to maintain homeostasis and facilitate regeneration or repair.
Tong-Zhou Liang +7 more
doaj +2 more sources
Influence of Iron on Bone Homeostasis [PDF]
Pharmaceuticals, 2018 Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be tightly regulated and orchestrated.
Enikő Balogh +2 more
doaj +3 more sources
Regulation of bone homeostasis: signaling pathways and therapeutic targets [PDF]
MedCommAs a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction homeostasis.
Zebin Wu +11 more
doaj +2 more sources
The skeletal phenotype of chondroadherin deficient mice [PDF]
, 2013 Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their a2b1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell ...
A Franzen +44 more
core +13 more sources
Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review
Journal of Functional Biomaterials, 2022 Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance between bone resorption and bone formation. The regulation of physiological bone remodeling by a complex system that involves multiple cells in the skeleton is closely ...
Yingkun Hu +7 more
doaj +1 more source