Results 41 to 50 of about 555,730 (303)
Bone morphogenic proteins in iron homeostasis
Bone, 2020 The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis. Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron ...
Xia, Xiao +2 more
openaire +3 more sources
CellsFibrous dysplasia (FD) is a mosaic skeletal disorder involving the development of benign, expansile fibro-osseous lesions during childhood that cause deformity, fractures, pain, and disability. There are no well-established treatments for FD.
Layne N. Raborn +4 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Butyrophilins, which are members of the extended B7 family of immunoregulators structurally related to the B7 family, have diverse functions on immune cells as co-stimulatory and co-inhibitory molecules.
Michael Frech +11 more
doaj +1 more source
Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]
, 2017 Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti +3 more
core +2 more sources
Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease
Frontiers in Cell and Developmental Biology, 2021 Hypoxia-inducible factors (HIFs) have become key transcriptional regulators of metabolism, angiogenesis, erythropoiesis, proliferation, inflammation and metastases. HIFs are tightly regulated by the tissue microenvironment.
Xianyi Meng +3 more
doaj +1 more source
In Search of a Role for Extracellular Purine Enzymes in Bone Function
Biomolecules, 2021 Bone is one of the major tissues that undergoes continuous remodeling throughout life, thus ensuring both organic body growth during development and protection of internal organs as well as repair of trauma during adulthood.
Mariachiara Zuccarini +4 more
doaj +1 more source
MicroRNAs as regulators of bone homeostasis and bone metastasis [PDF]
bonekey Reports, 2014 MicroRNAs (miRNAs) are short, endogenous RNAs that have essential roles in regulating gene expression through the disruption of target genes. The miRNA-induced suppression can occur through Argonaute-mediated cleavage of target mRNAs or by translational inhibition.
Brian, Ell, Yibin, Kang
openaire +2 more sources
Distinct Glucocorticoid Receptor Actions in Bone Homeostasis and Bone Diseases
Frontiers in Endocrinology, 2022 Glucocorticoids (GCs) are steroid hormones that respond to stress and the circadian rhythm. Pharmacological GCs are widely used to treat autoimmune and chronic inflammatory diseases despite their adverse effects on bone after long-term therapy. GCs regulate bone homeostasis in a cell-type specific manner, affecting osteoblasts, osteoclasts, and ...
Lee, Sooyeon +3 more
openaire +4 more sources
Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]
, 2012 Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Weidenbusch, Marc, Anders, Hans-Joachim
core +3 more sources
MIF contributes to Trypanosoma brucei associated immunopathogenicity development [PDF]
, 2014 African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response, whereby M1-type ...
Beschin, Alain +11 more
core +4 more sources