Results 41 to 50 of about 399,329 (296)

Bone morphogenetic protein signaling in bone homeostasis

Bone, 2015
Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth factor-β (TGF-β) superfamily. They play multiple functions during development and tissue homeostasis, including regulation of the bone homeostasis. The BMP signaling pathway consists in a well-orchestrated manner of ligands, membrane receptors, co-receptors and ...
Sanchez Duffhues, G., Hiepen, C., Knaus, P., Dijke, P. ten   +3 more
openaire   +3 more sources

In Search of a Role for Extracellular Purine Enzymes in Bone Function

Biomolecules, 2021
Bone is one of the major tissues that undergoes continuous remodeling throughout life, thus ensuring both organic body growth during development and protection of internal organs as well as repair of trauma during adulthood.
Mariachiara Zuccarini, Patricia Giuliani, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio   +4 more
doaj   +1 more source

Complement involvement in bone homeostasis and bone disorders

Seminars in Immunology, 2018
An integral part of innate immunity is the complement system, a defence system, consisting of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to danger factors and thus promoting host defence against pathogens has been well described already for decades. Recently, numerous further reaching functions of complement have
Yvonne, Mödinger, Bettina, Löffler, Markus, Huber-Lang, Anita, Ignatius   +3 more
openaire   +2 more sources

Low vitamin D status adversely affects bone health parameters in adolescents [PDF]

, 2008
Background: The effects of subclinical vitamin D deficiency on bone mineral density (BMD) and bone turnover in adolescents, especially in boys, are unclear.Objective: We aimed to investigate the relations of different stages of vitamin D status and BMD ...
Cashman, Kevin D, Tom R Hill, Robson, Paula J, Kiely, Mairead, Wallace, Julie MW, Werner Dubitzky, Flynn, Albert, Dubitzky, Werner, Kevin D Cashman, Liam Murray, Paula J Robson, Julie MW Wallace, Colin A Boreham, JJ Strain, Cotter, Alice A, Albert Flynn, Mairead Kiely, Strain, J J, Boreham, Colin A, Hill, Tom R, Murray, Liam, Alice A Cotter   +21 more
core   +1 more source

Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis [PDF]

, 2010
Energy-dependent intestinal calcium absorption is important for the maintenance of calcium and bone homeostasis, especially when dietary calcium supply is restricted.
Stockmans, I, Christakos, S, Bouillon, R, Benn, B S, Moermans, K, Lieben, L, Hediger, M A, Carmeliet, G, Ajibade, D, Peng, J B   +9 more
core   +1 more source

Fibroblast Activation Protein Is Expressed by Altered Osteoprogenitors and Associated to Disease Burden in Fibrous Dysplasia

Cells
Fibrous dysplasia (FD) is a mosaic skeletal disorder involving the development of benign, expansile fibro-osseous lesions during childhood that cause deformity, fractures, pain, and disability. There are no well-established treatments for FD.
Layne N. Raborn, Zachary Michel, Michael T. Collins, Alison M. Boyce, Luis F. de Castro   +4 more
doaj   +1 more source

Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia

Advanced Science, 2020
Mounting evidence is revealing that heavy metals can incur disordered bone homeostasis, leading to the development of degenerative bone diseases, including osteoporosis, osteoarthritis, degenerative disk disease, and osteomalacia.
Shuping Zhang, Li Sun, Jie Zhang, Sijin Liu, Jinxiang Han, Yajun Liu   +5 more
doaj   +1 more source

Experience with ospemifene in patients with vulvar and vaginal atrophy: case studies with bone marker profiles

Drugs in Context, 2020
Selective estrogen receptor modulators (SERMs) exhibit varying agonist/antagonist activities on estrogen receptors in tissues, although most SERMs, including ospemifene, have agonist effects on bone.
María del Carmen Pingarrón Santofimia, Silvia Pilar González Rodríguez, Mariella Lilue, Santiago Palacios   +3 more
doaj   +1 more source

Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: An Advanced Treatment Modality for Autologous Cell Therapy [PDF]

, 2009
Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their ...
Hermann, Patrick C., Schwarz, Theresa M., Kopp, Reinhard, Huber, Stephan, Heeschen, Christopher, Herrler, Tanja, Leicht, Simon F.   +6 more
core   +1 more source

Basolateral Amygdala Mediates Central Mechanosensory Feedback of Musculoskeletal System

Frontiers in Molecular Neuroscience, 2022
Musculoskeletal diseases, such as osteoporosis and sarcopenia, are tremendous and growing public health concerns. Considering the intimate functional relationship between muscle and bone throughout development, growth, and aging, muscle provides the ...
Nian Liu, Nian Liu, Botai Li, Botai Li, Lu Zhang, Dazhi Yang, Fan Yang   +6 more
doaj   +1 more source