Results 61 to 70 of about 399,329 (296)

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches [PDF]

, 2016
Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate ...
Raggatt, Liza Jane, Levesque, Jean-Pierre, Batoon, Lena, Hume, David Arthur, Pettit, Allison Robyn, Kaur, Simranpreet   +5 more
core   +1 more source

Estrogen-Related Receptor α: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis [PDF]

, 2022
Bone homeostasis is maintained with the balance between bone formation and bone resorption, which is involved in the functional performance of osteoblast and osteoclast. Disruption of this equilibrium usually causes bone disorders including osteoporosis,
Xiaojie Tang, Jiangwei Tan, Xu, Zhaowei, Cao, Haifei, Haifei Cao, Feng, Chun, Zhaowei Xu, Tan, Jiangwei, Guilong Zhang, Tang, Xiaojie, Zhang, Guilong, Chun Feng   +11 more
core   +1 more source

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Pharmaceutics, 2023
Bone-related diseases are major problems and heavy burdens faced by modern society. Current clinical approaches for the treatment of these pathological conditions often lead to complications and have limited therapeutic efficacy.
Jiawen Huang, Yang Xu, Yuxuan Wang, Zhiang Su, Tingting Li, Sisi Wu, Yuheng Mao, Shihua Zhang, Xiquan Weng, Yu Yuan   +9 more
doaj   +1 more source

RANKL in bone homeostasis [PDF]

Science, 2018
Physiology![Figure][1] Osteoporosis reduces bone density because of imbalances in signaling feedbacks. PHOTO: ALAN BOYDE/VISUALS UNLIMITED, INC. Synthesis and breakdown of bone are tightly coupled to preserve skeletal function. Ikebuchi et al. show that signaling via a transmembrane receptor protein called receptor activator of nuclear factor–kappa
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Unveiling the intricacies of bone homeostasis: Epigenetic regulation, extracellular vesicles, and angiogenesis integration

Extracellular Vesicle
Bone homeostasis is a complex process involving the coordinated actions of various bone cells and their interactions with the surrounding microenvironment.
Célio Junior da Costa Fernandes
doaj   +1 more source

Imbalance of Bone Homeostasis Caused by Nrf2 Deficiency Leads to Bone Loss in OVX Rats. [PDF]

Stem Cells Int
Conclusion: Nrf2 deficiency may contribute to PMOP by disrupting bone homeostasis. Activation of Nrf2 may represent a potential therapeutic strategy for restoring bone balance and treating ...
Sun P, Wang Z, Chen S, Chen X, Zhou F, Zhang C, Yang J, Huang Y, Lin Y.   +8 more
europepmc   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Autophagy in bone homeostasis and the onset of osteoporosis [PDF]

Bone Research, 2019
AbstractAutophagy is an evolutionarily conserved intracellular process, in which domestic cellular components are selectively digested for the recycling of nutrients and energy. This process is indispensable for cell homeostasis maintenance and stress responses.
Xing Yin, Chenchen Zhou, Jingtao Li, Renkai Liu, Bing Shi, Quan Yuan, Shujuan Zou   +6 more
openaire   +2 more sources