Synovial tissue macrophages: friend or foe? [PDF]
, 2017 Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce ...
Alivernini, Stefano +1 more
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Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]
, 2017 Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran +15 more
core +2 more sources
Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle [PDF]
, 2017 The estimates of global incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major
Chiesa, Claudio +4 more
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Nutrition-Related Peptides and Bone Homeostasis [PDF]
Journal of Bone and Mineral Research, 2006 THE SKELETON SERVES two main functions. First, it has a structural role, to support, protect, and facilitate the function of the soft tissues. Second, it is a mineral reservoir, which can be drawn on when dietary intake is inadequate to meet the body’s needs.
Ian R, Reid +2 more
openaire +2 more sources
Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss
Bone Reports, 2019 Type I and Type II Diabetes dramatically impair skeletal health. Altered Insulin Receptor (IR) signaling is a common feature of both diseases, and insulin has potent bone anabolic functions.
Valentina Studentsova +2 more
doaj +1 more source
Skeletal homeostasis in tissue‐engineered bone [PDF]
Journal of Orthopaedic Research, 2003 AbstractTissue‐engineering strategies to stimulate bone regeneration may offer an alternative approach to conventional orthopaedic and maxillofacial surgical therapies. Over the last decade, significant advances have been accomplished in developing biomimetic matrices, growth factors, cell transplantation and gene delivery therapeutics to support new ...
Schneider, Abraham +3 more
openaire +3 more sources
The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis
Frontiers in Endocrinology, 2022 Nuclear factor E2-related factor 2(Nrf2) is a transcription factor that mainly regulates oxidative stress in the body. It initiates the expression of several downstream antioxidants, anti-inflammatory proteins and detoxification enzymes through the Kelch-
Fengyu Ma +13 more
doaj +1 more source
The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]
, 2013 The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves +3 more
core +1 more source
Complement involvement in bone homeostasis and bone disorders
Seminars in Immunology, 2018 An integral part of innate immunity is the complement system, a defence system, consisting of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to danger factors and thus promoting host defence against pathogens has been well described already for decades. Recently, numerous further reaching functions of complement have
Yvonne, Mödinger +3 more
openaire +2 more sources
Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass [PDF]
, 2011 Context: The hormonal factors involved in the regulation of peak bone mass (PBM) in men have not been fully investigated. Apart from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis and are ...
Fiers, Tom +6 more
core +2 more sources