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Proceedings of the National Academy of Sciences, 1998 The functions of bone(s) are (i) mechanical support of soft tissues, (ii) levers for muscle action, (iii) protection of the central nervous system, (iv) release of calcium and other ions for the maintenance of a constant ionic environment in the extracellular fluid, and (v) housing and support of hemopoiesis.
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Aromatase Activity and Bone Homeostasis in Men [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2004 It is known that sex steroid hormones play an important role in the maintenance of bone mass in males as well as in females. Even though androgens are the major sex steroids in men, their primacy in regulating male skeletal remodeling has been increasingly questioned as direct and indirect evidence emerged suggesting that estrogens may also play a ...
GENNARI, LUIGI +2 more
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Sirtuin function and metabolism: Role in pancreas, liver, and adipose tissue and their crosstalk impacting bone homeostasis [PDF]
, 2022 International audienceMammalian sirtuins (SIRT1–7) are members of the nicotine adenine dinucleotide (NAD+)-dependent family of enzymes critical for histone deacetylation and posttranslational modification of proteins.
Avilkina, Viktorija +2 more
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The Osteocyte: From “Prisoner” to “Orchestrator”
Journal of Functional Morphology and Kinesiology, 2021 Osteocytes are the most abundant bone cells, entrapped inside the mineralized bone matrix. They derive from osteoblasts through a complex series of morpho-functional modifications; such modifications not only concern the cell shape (from prismatic to ...
Carla Palumbo, Marzia Ferretti
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The Involvement of TRP Channels in Bone Homeostasis [PDF]
Frontiers in Endocrinology, 2012 Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney.
Lieben, Liesbet, Carmeliet, Geert
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Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo [PDF]
, 2008 Resident macrophages are an integral component of many tissues and are important in homeostasis and repair. This study examines the contribution of resident tissue macrophages to bone physiology.
Chang, M. K. +28 more
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Fibroblast growth factor 21 and bone homeostasis [PDF]
, 2023 Fibroblast growth factor 21 (FGF21), a member of the FGF subfamily, is produced primarily in the liver and adipose tissue. The main function of FGF21 is to regulate energy metabolism of carbohydrates and lipids in the body through endocrine and other ...
Yan Tang, Mei Zhang
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The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis
Frontiers in Endocrinology, 2022 Nuclear factor E2-related factor 2(Nrf2) is a transcription factor that mainly regulates oxidative stress in the body. It initiates the expression of several downstream antioxidants, anti-inflammatory proteins and detoxification enzymes through the Kelch-
Fengyu Ma +13 more
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The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation [PDF]
, 2010 Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation.
Maronde, E. (Erik) +33 more
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Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes [PDF]
, 2014 The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease.
Elspeth M. Milne +27 more
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