Results 11 to 20 of about 555,730 (303)
Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases
Frontiers in Pharmacology, 2023 Bone homeostasis refers to the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption and the maintenance of stable bone mass. SIRT3 is a class of mitochondrial protein deacetylase that influences various mitochondrial
Ke Xu +5 more
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Recent Progress in Osteocyte Research [PDF]
Endocrinology and Metabolism, 2013 The last decade has seen an exponential increase in our understanding of osteocytes function and biology. These cells, once considered inert by-standers trapped into the mineralized bone, has now risen to be key regulators of skeletal metabolism, mineral
Paola Divieti Pajevic
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Peripheral nerves in the tibial subchondral bone: the role of pain and homeostasis in osteoarthritis
Bone & Joint Research, 2022 Osteoarthritis (OA) is a highly prevalent degenerative joint disorder characterized by joint pain and physical disability. Aberrant subchondral bone induces pathological changes and is a major source of pain in OA.
Qi Sun +6 more
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Break and then stand: novel insight into osteoclast functions in the skeletal system
Di-san junyi daxue xuebao, 2022 The skeleton provides the scaffold to support body weight, enable body movement, control mineral homeostasis, and provide the location for hematopoiesis.
DONG Shiwu, HU Wenhui
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The unbearable lightness of bone marrow homeostasis [PDF]
, 2015 The anatomical and functional dimensions of bone marrow topography have been at the forefront of modern bone and immunological research for many years and remain a source of complexity and perplexity due to the multitude of microhabitats within this ...
AGAS, DIMITRIOS +3 more
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Proceedings of the National Academy of Sciences, 1998 The functions of bone(s) are (i) mechanical support of soft tissues, (ii) levers for muscle action, (iii) protection of the central nervous system, (iv) release of calcium and other ions for the maintenance of a constant ionic environment in the extracellular fluid, and (v) housing and support of hemopoiesis.
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Polycyclic aromatic hydrocarbons in bone homeostasis
Biomedicine & Pharmacotherapy, 2022 Prolonged exposure to polycyclic aromatic hydrocarbons (PAHs) may result in autoimmune diseases, such as rheumatoid arthritis (RA) and osteoporosis (OP), which are based on an imbalance in bone homeostasis. These diseases are characterized by bone erosion and even a disruption in homeostasis, including in osteoblasts and osteoclasts.
Qinbin, Ye +9 more
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The Osteocyte: From “Prisoner” to “Orchestrator”
Journal of Functional Morphology and Kinesiology, 2021 Osteocytes are the most abundant bone cells, entrapped inside the mineralized bone matrix. They derive from osteoblasts through a complex series of morpho-functional modifications; such modifications not only concern the cell shape (from prismatic to ...
Carla Palumbo, Marzia Ferretti
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Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]
, 2017 The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef +9 more
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Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases
Pharmaceutics, 2023 Bone-related diseases are major problems and heavy burdens faced by modern society. Current clinical approaches for the treatment of these pathological conditions often lead to complications and have limited therapeutic efficacy.
Jiawen Huang +9 more
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