Results 31 to 40 of about 555,730 (303)

Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases [PDF]

International Journal of Molecular Sciences, 2020
Zinc is an essential micronutrient that plays critical roles in numerous physiological processes, including bone homeostasis. The majority of zinc in the human body is stored in bone. Zinc is not only a component of bone but also an essential cofactor of many proteins involved in microstructural stability and bone remodeling.
Tongling Huang, Guoyong Yan, Min Guan
openaire   +2 more sources

Small-molecule amines: a big role in the regulation of bone homeostasis

Bone Research, 2023
Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration regardless of whether they are applied as drugs or biomaterials.
Qian Zhang, Jirong Yang, Nan Hu, Juan Liu, Huan Yu, Haobo Pan, Di Chen, Changshun Ruan   +7 more
doaj   +1 more source

Induction of WNT16 via peptide-mRNA nanoparticle-based delivery maintains cartilage homeostasis [PDF]

, 2020
Osteoarthritis (OA) is a progressive joint disease that causes significant disability and pain and for which there are limited treatment options. We posit that delivery of anabolic factors that protect and maintain cartilage homeostasis will halt or ...
Akk, Antonina, Hu, Ying, Pan, Hua, Pham, Christine T N, Rai, Muhammad Farooq, Wickline, Samuel A, Yan, Huimin   +6 more
core   +2 more sources

Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis

Frontiers in Medicine, 2023
Osteoporosis stands out as a prevalent metabolic disorder, bearing significant repercussions on human well-being and overall quality of life. It remains an urgent concern within the global public health framework due to its widespread occurrence ...
Guochen Wang, Guochen Wang, Yubo Meng, Yubo Meng, Wensi Ouyang, Wensi Ouyang, Changwei Zhao, Changwei Zhao, Wenhai Zhao, Wenhai Zhao   +9 more
doaj   +1 more source

Homeostasis as the Mechanism of Evolution. [PDF]

, 2015
Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic ...
Torday, John S
core   +2 more sources

RANKL in bone homeostasis [PDF]

Science, 2018
Physiology![Figure][1] Osteoporosis reduces bone density because of imbalances in signaling feedbacks. PHOTO: ALAN BOYDE/VISUALS UNLIMITED, INC. Synthesis and breakdown of bone are tightly coupled to preserve skeletal function. Ikebuchi et al. show that signaling via a transmembrane receptor protein called receptor activator of nuclear factor–kappa
openaire   +1 more source

Benincasa hispida Extract Prevents Ovariectomy-Induced Osteoporosis in Female ICR Mice

Applied Sciences, 2023
With the increase in bone metabolic diseases owing to the aging of the global population, interest in functional food ingredients for improving bone health is increasing.
Sun-Il Choi, Xionggao Han, Xiao Men, Se-Jeong Lee, Geon Oh, Ye-Eun Choi, Jung-Mo Yang, Ju-Hyun Cho, Ok-Hwan Lee   +8 more
doaj   +1 more source

Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia

Advanced Science, 2020
Mounting evidence is revealing that heavy metals can incur disordered bone homeostasis, leading to the development of degenerative bone diseases, including osteoporosis, osteoarthritis, degenerative disk disease, and osteomalacia.
Shuping Zhang, Li Sun, Jie Zhang, Sijin Liu, Jinxiang Han, Yajun Liu   +5 more
doaj   +1 more source

The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings

Frontiers in Immunology, 2022
ObjectiveThe programmed death-1 (PD-1) pathway is essential for maintaining self-tolerance and plays an important role in autoimmunity, including rheumatoid arthritis (RA).
Stinne R. Greisen, Stinne R. Greisen, Tue W. Kragstrup, Tue W. Kragstrup, Jesper Skovhus Thomsen, Kim Hørslev-Pedersen, Merete Lund Hetland, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Mikkel Østergaard, Lykke Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Malene Hvid, Malene Hvid, Søren K. Moestrup, Ellen Margrethe Hauge, Ellen Margrethe Hauge, Bent Deleuran, Bent Deleuran   +21 more
doaj   +1 more source

Growth hormone deficiency during young adulthood and the benefits of growth hormone replacement [PDF]

, 2016
Until quite recently, the management of children with growth hormone deficiency (GHD) had focussed on the use of recombinant human GH (rhGH) therapy to normalise final adult height.
Ahmed, S.F., Ahmid, M., Perry, C.G., Shaikh, M.G.   +3 more
core   +2 more sources