Results 31 to 40 of about 399,329 (296)

Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis

Frontiers in Medicine, 2023
Osteoporosis stands out as a prevalent metabolic disorder, bearing significant repercussions on human well-being and overall quality of life. It remains an urgent concern within the global public health framework due to its widespread occurrence ...
Guochen Wang, Guochen Wang, Yubo Meng, Yubo Meng, Wensi Ouyang, Wensi Ouyang, Changwei Zhao, Changwei Zhao, Wenhai Zhao, Wenhai Zhao   +9 more
doaj   +1 more source

Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice [PDF]

, 2011
Down syndrome (DS) is a genetic disorder resulting from trisomy 21 that causes cognitive impairment, low muscle tone and craniofacial alterations. Morphometric studies of the craniofacial and appendicular skeleton in individuals with DS suggest that bone
Roper, Randall J., Blazek, Joshua D., Anna Gaddy, Jiliang Li, Meyer, Rachel, Li, Jiliang, Gaddy, Anna, Rachel Meyer, Randall J. Roper, Joshua D. Blazek   +9 more
core   +1 more source

Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss

Bone Reports, 2019
Type I and Type II Diabetes dramatically impair skeletal health. Altered Insulin Receptor (IR) signaling is a common feature of both diseases, and insulin has potent bone anabolic functions.
Valentina Studentsova, Emma Knapp, Alayna E. Loiselle   +2 more
doaj   +1 more source

Benincasa hispida Extract Prevents Ovariectomy-Induced Osteoporosis in Female ICR Mice

Applied Sciences, 2023
With the increase in bone metabolic diseases owing to the aging of the global population, interest in functional food ingredients for improving bone health is increasing.
Sun-Il Choi, Xionggao Han, Xiao Men, Se-Jeong Lee, Geon Oh, Ye-Eun Choi, Jung-Mo Yang, Ju-Hyun Cho, Ok-Hwan Lee   +8 more
doaj   +1 more source

A novel model to explain dietary factors affecting hypocalcaemia in dairy cattle [PDF]

, 2011
Most dairy cows exhibit different degrees of hypocalcaemia around calving because the gestational Ca requirements shift to the disproportionately high Ca requirements of lactation.
Verstegen, M.W.A., Martin W. A. Verstegen, Martin-Tereso Lopez, J., Javier Martín-Tereso   +3 more
core   +1 more source

The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings

Frontiers in Immunology, 2022
ObjectiveThe programmed death-1 (PD-1) pathway is essential for maintaining self-tolerance and plays an important role in autoimmunity, including rheumatoid arthritis (RA).
Stinne R. Greisen, Stinne R. Greisen, Tue W. Kragstrup, Tue W. Kragstrup, Jesper Skovhus Thomsen, Kim Hørslev-Pedersen, Merete Lund Hetland, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Mikkel Østergaard, Lykke Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Malene Hvid, Malene Hvid, Søren K. Moestrup, Ellen Margrethe Hauge, Ellen Margrethe Hauge, Bent Deleuran, Bent Deleuran   +21 more
doaj   +1 more source

RANKL-Induced Btn2a2 – A T Cell Immunomodulatory Molecule – During Osteoclast Differentiation Fine-Tunes Bone Resorption

Frontiers in Endocrinology, 2021
Butyrophilins, which are members of the extended B7 family of immunoregulators structurally related to the B7 family, have diverse functions on immune cells as co-stimulatory and co-inhibitory molecules.
Michael Frech, Michael Frech, Gregor Schuster, Gregor Schuster, Fabian T. Andes, Fabian T. Andes, Georg Schett, Georg Schett, Mario M. Zaiss, Mario M. Zaiss, Kerstin Sarter, Kerstin Sarter   +11 more
doaj   +1 more source

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength [PDF]

, 2012
Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice ...
Gogakos Apostolos, Campbell, MJ, Anne H. van der Spek (145990), Campbell Michael J., Gogakos, A, Sunter, D, Williams, GR, David Sunter, Bassett, JHD, Boyde, A, Michael J. Campbell (5833), Sunter, D., Richard M Jacques, Project, S.M.G., Alan Boyde (146008), Croucher Peter I., Ramirez-Solis, R, Williams, G.R., Richard M. Jacques (145985), van der Spek Anne H., Holly Evans (145980), Bassett, J.H.D., Ryder, E, Edward Ryder (145998), Peter I. Croucher (146016), Graham R Williams, Evans, H, Bassett J. H. Duncan, Jacques, RM, Anne H van der Spek, J. H. Duncan Bassett (145971), Croucher, PI, Peter I Croucher, Project, SMG, Ryder, E., David Sunter (146002), Holly Evans, Gogakos, A., Jacqueline K. White (119191), Apostolos Gogakos (145975), Ramirez-Solis, R., Jacqueline K White, White Jacqueline K., Boyde, A., van der Spek, A.H., Evans, H., Michael J Campbell, Ramirez-Solis Ramiro, White, J.K., Jacques, R.M., J H Duncan Bassett, Apostolos Gogakos, Jacques Richard M., Croucher, P.I., Ryder Edward, Graham R. Williams (20148), Campbell, M.J., Evans Holly, Ramiro Ramirez-Solis (119181), Williams Graham R., Ramiro Ramirez-Solis, Edward Ryder, Alan Boyde, van der Spek, AH, Sanger Mouse Genetics Project, Sunter David, White, JK, Boyde Alan   +67 more
core   +1 more source

Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease

Frontiers in Cell and Developmental Biology, 2021
Hypoxia-inducible factors (HIFs) have become key transcriptional regulators of metabolism, angiogenesis, erythropoiesis, proliferation, inflammation and metastases. HIFs are tightly regulated by the tissue microenvironment.
Xianyi Meng, Ben Wielockx, Martina Rauner, Aline Bozec   +3 more
doaj   +1 more source

FasL is a catabolic factor in alveolar bone homeostasis. [PDF]

, 2023
AIM Fas ligand (FasL) belongs to the tumor necrosis factor (TNF) superfamily regulating bone turnover, inflammation, and apoptosis. The appendicular and axial skeleton phenotype of mature Faslgld mice was reported.
Heimel, Patrick, Lee, Jung Seok, Patrick Heimel, Tangl, Stefan, Panahipour, Layla, Julie Marchesan, Stefan Tangl, Lettner, Stefan, Layla Panahipour, Gruber, Reinhard, Matalová, Eva, Reinhard Gruber, Jung Seok Lee, Marchesan, Julie, Karol Alí Apaza Alccayhuaman, Karol Alí, Apaza Alccayhuaman, Apaza Alccayhuaman, Karol Alí, Ulrike Kuchler, Stefan Lettner, Kuchler, Ulrike, Eva Matalová   +20 more
core   +1 more source