Results 11 to 20 of about 38,030 (279)
Osteocytes and Primary Cilia [PDF]
Current Osteoporosis Reports, 2023 Abstract Purpose of Review The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing. Recent Findings Osteocytes are thought to be the primary mechanosensing cells in bone tissue ...
Verbruggen, S.W. +2 more
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Aging, Osteocytes, and Mechanotransduction [PDF]
Current Osteoporosis Reports, 2017 The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging ...
Hemmatian, Haniyeh +3 more
core +9 more sources
Osteocytes and Weightlessness [PDF]
Current Osteoporosis Reports, 2021 Abstract Purpose of Review Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions ...
Iandolo, Donata +3 more
openaire +7 more sources
MicroRNAs and osteocytes [PDF]
Bone, 2021 MicroRNAs, identified in the early 1990s, are believed to regulate approximately 30% of the human genome. The role of microRNA in bone cells was first reported in 2007 in a manuscript showing that microRNA-223 is essential for osteoclast differentiation in vitro, and a few studies reported a role of microRNAs in osteoblasts the same year.
Plotkin, Lilian I., Wallace, Joseph M.
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Osteocytes and Skeletal Pathophysiology [PDF]
Current Molecular Biology Reports, 2015 For many years, osteocytes have been the forgotten bone cells and considered as inactive spectators buried in the bone matrix. We now know that osteocytes detect and respond to mechanical and hormonal stimuli to coordinate bone resorption and bone formation.
Delgado-Calle, Jesus, Bellido, Teresita
openaire +4 more sources
The Role of Osteocytes in Inflammatory Bone Loss [PDF]
Frontiers in Endocrinology, 2019 Osteoimmunology investigations to-date have demonstrated the significant interactions between bone surface cells, osteoclasts and osteoblasts, and immune cells.
Corinne E. Metzger, S. Anand Narayanan
doaj +3 more sources
Osteocytes but not osteoblasts directly build mineralized bone structures [PDF]
, 2021 Bone-forming osteoblasts have been a cornerstone of bone biology for more than a century. Most research toward bone biology and bone diseases center on osteoblasts. Overlooked are the 90% of bone cells, called osteocytes.
Wang, Ke +14 more
core +1 more source
Osteocyte Mechanobiology [PDF]
Current Osteoporosis Reports, 2017 Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells.Whereas increased mechanical forces promote bone formation ...
Yuhei, Uda +4 more
openaire +2 more sources
Mechanosensitivity of osteocytes in their native matrix [PDF]
, 2023 Osteocytes sense and transduce mechanical signals into biochemical signals, thereby regulating the adaptation of bone to mechanical loading. Their deep location in hard mineralized bone matrix hinders their isolation from bone, and thereby limits studies
Zhang, Chen
core +1 more source
Bone, 2013 Apoptotic death of osteocytes was recognized over 15 years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen deficiency and perhaps in other ...
Robert L, Jilka +2 more
openaire +2 more sources