Results 21 to 30 of about 55,714 (303)

CSF‐1 in Osteocytes Inhibits Nox4‐mediated Oxidative Stress and Promotes Normal Bone Homeostasis

JBMR Plus, 2020
CSF‐1 is a key factor in regulating bone remodeling; osteocytes express CSF‐1 and its receptor. Viable osteocytes are essential for bone remodeling through cell–cell contact and secretion of factors that regulate osteoblasts and osteoclasts.
Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug‐Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jiang   +11 more
doaj   +1 more source

Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone

Bone & Joint Research, 2022
Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA.
Jun Zhou, Zhiyi He, Jiarui Cui, Xiaoling Liao, Hui Cao, Yo Shibata, Takashi Miyazaki, Jiaming Zhang   +7 more
doaj   +1 more source

The roles of osteocytes in alveolar bone destruction in periodontitis

Journal of Translational Medicine, 2020
Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis is crucial for understanding its pathogenesis.
Xiaofei Huang, Mengru Xie, Yanling Xie, Feng Mei, Xiaofeng Lu, Xiaoshuang Li, Lili Chen   +6 more
doaj   +1 more source

Osteocytes and mechanical loading: The Wnt connection [PDF]

, 2019
Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell‐ and tissue‐level properties of mechanotransduction to achieve alignment and reorganization of the dentition.
Ahn Y, Balemans W, Cui Y, Fu HD, Gong Y, Harris SE, Leupin O, Lim WH, Little RD, Loots GG, Niziolek PJ, Odagaki N, Ohazama A, Poole KE, Robling AG, Sawakami K, Saxon LK, Semenov M, Tu X, Van Wesenbeeck L, Zhao L, Zong Y   +21 more
core   +1 more source

The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be necessary for skeletal growth and health and to play a role in actin-based ...
Beth S. Lee, Cynthia Murray, Jie Liu, Minji Kim, Min Sik Hwang, Tina Yueh, Myrna Mansour, Sana Qamar, Gunjan Agarwal, Do-Gyoon Kim   +9 more
doaj   +1 more source

Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts [PDF]

, 2008
The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication.
Ishihara, Yoshihito, Kamioka, Hiroshi, Lim, Soo-Siang, Murshid, Sakhr A., Ris, Hans, Sugawara, Yasuyo, Yamamoto, Teruko Takano   +6 more
core   +1 more source

The amazing osteocyte [PDF]

Journal of Bone and Mineral Research, 2010
Abstract The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity ...
openaire   +2 more sources

Effect of Low-magnitude, High-frequency Vibration on Osteocytes in the Regulation of Osteoclasts [PDF]

, 2010
Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that
Al-Dujaili, Saja, Guenther, Axel, Lau, Esther, Liu, Dawei, Wang, Liyun, You, Lidan   +5 more
core   +2 more sources

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading [PDF]

, 2014
The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β ...
Akhter, Armstrong, Armstrong, Babij, Bodine, Bodine, Bonewald, Bouxsein, Boyden, Case, Choi, Dallas, Dempster, Diarra, Doube, Galea, Glass, Gong, Hens, Holmen, Holmen, Javaheri, Johnson, Johnson, Johnson, Kamel, Kato, Kitase, Korecki, Kramer, Lau, Li, Little, Logan, Lu, Monga, Nakashima, Nathke, Nusse, Pinson, Polakis, Reya, Robinson, Santos, Sawakami, Saxon, Schneider, Sen, Srivastava, Sunters, Wijenayaka, Xing, Xiong, Yao   +53 more
core   +2 more sources

Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement

Journal of Immunology Research, 2019
Osteocytes are abundant cells in bone, which contribute to bone maintenance. Osteocytes express receptor activator of nuclear factor kappa-B ligand (RANKL) and regulate osteoclast formation.
Fumitoshi Ohori, Hideki Kitaura, Aseel Marahleh, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi   +9 more
doaj   +1 more source