Results 51 to 60 of about 134,929 (355)

Osteoclasts and hematopoiesis [PDF]

BoneKEy Reports, 2012
The skeletal tissue is closely associated with the hematopoietic tissue lodged in its inner cavities. Besides the well-known role of the endosteal osteoblasts in the maintenance of the hematopoietic stem cell (HSC) niche, it is an emerging concept that osteoclasts are involved in the regulation of hematopoiesis as well, although published data are ...
openaire   +3 more sources

Osteoclasts prefer aged bone [PDF]

, 2007
We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone.
Henriksen, K, Leeming, Diana Julie, Martin, T John, Byrjalsen, I, Qvist, P, Dziegiel, Morten Hanefeld, Sorensen, M G, Christiansen, C, Karsdal, M A, Nielsen, R H   +9 more
core   +1 more source

T cell suppression by osteoclasts in vitro [PDF]

, 2011
T cells are critical regulators of osteoclast differentiation and function in bone, but whether osteoclasts can, in turn, regulate T cell homing, and response to stimuli is unclear.
FACCHINI, ANDREA, Cattini L., Manferdini C., Piacentini A., Lisignoli G., Grassi F., Gabusi E.   +6 more
core   +1 more source

Detection of transcripts for the receptor for macrophage colony-stimulating factor, c-fms, in murine osteoclasts. [PDF]

, 1992
Macrophage colony-stimulating factor (M-CSF), whose action is restricted to the cell populations of the mononuclear phagocyte system, has recently been found to be required for osteoclastogenesis and bone resorption.
Mueller, C, Felix, R, C. Mueller, Wetterwald, A, Cecchini, M C, M. C. Cecchini, R. Felix, H. Fleisch, A. Wetterwald, Hofstetter, W, W. Hofstetter, Fleisch, H   +11 more
core   +1 more source

Macrophages and osteoclasts: similarity and divergence between bone phagocytes

Frontiers in Immunology
Both macrophages and osteoclasts are vital immune components of the bone microenvironment. While macrophages play an essential role in phagocytosis, pathogen clearance and tissue remodeling, osteoclasts are well described for their bone resorption ...
Julia Halper, Bastien Dolfi, Stoyan Ivanov, Maria-Bernadette Madel, Claudine Blin-Wakkach   +4 more
doaj   +1 more source

The effects of seeding density and osteoclastic supplement concentration on osteoclastic differentiation and resorption

Bone Reports, 2023
The bone resorbing osteoclasts are a complex type of cell essential for in vivo bone remodeling. There is no consensus on medium composition and seeding density for in vitro osteoclastogenesis, despite the importance thereof on osteoclastic ...
Stefan J.A. Remmers, Freek C. van der Heijden, Keita Ito, Sandra Hofmann   +3 more
doaj   +1 more source

Osteoclasts in Health and Disease [PDF]

, 2019
Osteoclasts are multinucleated, giant cells originating from myeloid hematopoetic stem cells. These are the only cells in nature which can resorb bone.
Lerner, Ulf H,
core   +1 more source

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion

Biology, 2023
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing   +8 more
doaj   +1 more source

Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice

Nature Communications, 2019
Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear. Here we report that in mice, osteoclasts induce sensory innervation in the porous endplates which contributes to spinal hypersensitivity in mice ...
Shuangfei Ni, Zemin Ling, Xiao Wang, Yong Cao, Tianding Wu, Ruoxian Deng, Janet L. Crane, R. Skolasky, S. Demehri, G. Zhen, Amit Jain, Panfeng Wu, Dayu Pan, Bo Hu, Xiao Lyu, YuSheng Li, Hao Chen, Huabin Qi, Y. Guan, Xinzhong Dong, M. Wan, X. Zou, Hongbin Lu, Jianzhong Hu, Xu Cao   +24 more
semanticscholar   +1 more source

TRAP staining: Osteoclasts formation in different groups. [PDF]

, 2014
(A) Healthy control group. (B) Untreated periodontitis group. (C) iPSC-MSCs treated periodontitis group. (D) iPSC-MSCs/TSG-6 treated periodontitis group.
Raydolfo M. Aprecio (590401), Yi Ding (172783), Wu Zhang (220174), Yiming Li (40290), Xiaodong Zhou (86982), Qi Wang (22418), Heng Yang (590400)   +6 more
core   +1 more source