Results 71 to 80 of about 88,889 (259)

Osteoclasts in Health and Disease

, 2019
Osteoclasts are multinucleated, giant cells originating from myeloid hematopoetic stem cells. These are the only cells in nature which can resorb bone.
Lerner, Ulf H,
core   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo [PDF]

, 2010
NHA2 was recently identified as a novel sodium/hydrogen exchanger which is strongly upregulated during RANKL-induced osteoclast differentiation. Previous in vitro studies suggested that NHA2 is a mitochondrial transporter required for osteoclast ...
Bonny, Olivier, Siegrist, M., Hofstetter, W., Bonny, O., Fuster, Daniel G, Simonin, Alexandre, Simonin, A., Siegrist, Mark, Hofstetter, Willy, Fuster, D.G., Simonin A, Siegrist M, Fuster DG, Hofstetter W, Bonny O, Alexandre Simonin, Daniel G. Fuster, Willy Hofstetter, Olivier Bonny, Mark Siegrist   +19 more
core   +1 more source

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Ultrastructural Features of Osteoclasts In Situ [PDF]

, 1989
The morphology of in situ osteoclasts on endocortical surfaces of the femoral midshaft was examined by scanning electron microscopy. Mice were perfusion fixed and bone marrow plugs were flushed out of femoral diaphyseal cylinders.
Jee, W. S. S., Miller, S. C., de Saint-Georges, L., Bowman., B. M.   +3 more
core   +1 more source

Engineering approaches to manipulate osteoclast behavior for bone regeneration

Materials Today Bio
Extensive research has delved into the multifaceted roles of osteoclasts beyond their traditional function in bone resorption in recent years, uncovering their significant influence on bone formation.
Xin Cheng, Wenzhi Tian, Jianhua Yang, Jiamian Wang, Yang Zhang   +4 more
doaj   +1 more source

Detection of transcripts for the receptor for macrophage colony-stimulating factor, c-fms, in murine osteoclasts.

, 1992
Macrophage colony-stimulating factor (M-CSF), whose action is restricted to the cell populations of the mononuclear phagocyte system, has recently been found to be required for osteoclastogenesis and bone resorption.
Mueller, C, Felix, R, C. Mueller, Wetterwald, A, Cecchini, M C, M. C. Cecchini, R. Felix, H. Fleisch, A. Wetterwald, Hofstetter, W, W. Hofstetter, Fleisch, H, Müller, Christoph, Wetterwald A, Hofstetter W, Cecchini MC, Fleisch H, Mueller C, Felix R   +18 more
core   +1 more source

Transgenic Mice for a Tamoxifen-Induced, Conditional Expression of the Cre Recombinase in Osteoclasts [PDF]

, 2012
Background: Studies on osteoclasts, the bone resorbing cells, have remained limited due to the lack of transgenic mice allowing the conditional knockout of genes in osteoclasts at any time during development or adulthood.
Sbacchi, S., Maria Arantzazu Sanchez-fern, Naumann, R. (R), Manfred Blessing (56059), Bernard Hoflack, Maria Arantzazu Sanchez-Fernandez (164567), Correa-Tapia, M., Blessing Manfred, Klemm, J., Klemm Jennifer, Correa-Tapia Miguel, Al-Robaiy, S., Correa-Tapia, M. (M), Miguel Correa-Tapia (164578), Al-Robaiy Samiya, Hoflack, B., Ronald Naumann (164582), Sbacchi, S. (S), Blessing, M. (M), In Osteoclasts, Blessing, M., Al-Robaiy, S. (S), Miguel Correa-tapia, Naumann Ronald, Jennifer Klemm (164588), Naumann, R., Pierre Chambon, Technische Universität Dresden, Sbacchi Silvia, Silvia Sbacchi (164572), Manfred Blessing, Chambon Pierre, Sanchez-Fernandez, M., Hoflack, B. (B), Pierre Chambon (12330), Chambon, P., Silvia Sbacchi, Samiya Al-Robaiy (164593), Hoflack Bernard, Klemm, J. (J), Samiya Al-Robaiy, Sanchez-Fernandez Maria Arantzazu, Maria Arantzazu Sanchez-Fernandez, Sanchez-Fernandez, M. (M) A. (A), Ronald Naumann, Jennifer Klemm, Bernard Hoflack (164600), Chambon, P. (Pierre), Al-Robaiy, Samiya, Blessing, Manfred, Naumann, Ronald, Hoflack, Bernard, Correa-Tapia, Miguel, Chambon, Pierre, Sanchez-Fernandez, Maria Arantzazu, Klemm, Jennifer, Sbacchi, Silvia   +56 more
core   +2 more sources

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source