Results 71 to 80 of about 134,929 (355)

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the Affected Bone

Frontiers in Immunology, 2021
Detailed characterization of medullary and extramedullary reservoirs of osteoclast progenitors (OCPs) is required to understand the pathophysiology of increased periarticular and systemic bone resorption in arthritis.
Darja Flegar, Darja Flegar, Maša Filipović, Maša Filipović, Alan Šućur, Alan Šućur, Antonio Markotić, Antonio Markotić, Nina Lukač, Nina Lukač, Dino Šisl, Dino Šisl, Marina Ikić Matijašević, Zrinka Jajić, Tomislav Kelava, Tomislav Kelava, Vedran Katavić, Vedran Katavić, Nataša Kovačić, Nataša Kovačić, Danka Grčević, Danka Grčević   +21 more
doaj   +1 more source

The Origin of Osteoclasts

Immunobiology, 1982
We are satisfied from studies with mi mi osteopetrotic mutant mice that osteoclasts arise from the myeloid tissue of bone marrow and not as formerly proposed from osteoprogenitor cells. Grafts of compatible normal myeloid cells cure the osteopetrosis by the substitution of the qualitatively defective osteoclasts with normal ones.
J F, Loutit, N W, Nisbet
openaire   +2 more sources

Distribution of Myo9b in osteoclasts. [PDF]

, 2014
Osteoclast podosomes and sealing zones were labeled with fluorescent phalloidin and anti-Myo9b antibodies and viewed by confocal microscopy. A, In mature osteoclasts on glass coverslips, Myo9b is at its highest levels in the perinuclear region and in the
Brooke K. McMichael (319210), Beth S. Lee (319215), Katharine F. Scherer (513269), Nicole C. Franklin (513270)   +3 more
core   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Research progress in the differentiation and function of osteoclasts in the inflammatory microenvironment

Kouqiang hemian waike zazhi
Osteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption. Inflammation serves as a significant inducer of pathological bone resorption.
WANG Jin, WANG Yabing, SU Jiansheng
doaj   +1 more source

Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice*

Journal of Biological Chemistry, 2016
Mammalian target of rapamycin complex 1 (mTORC1) is involved in anabolic metabolism in both osteoblasts and chondrocytes, but the role of mTORC1 in osteoclast biology in vivo remains to be elucidated.
Q. Dai, F. Xie, Yujiao Han, Xuhui Ma, Siru Zhou, Lingyong Jiang, Weiguo Zou, Jun Wang   +7 more
semanticscholar   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Effect of Urocortin on human osteoclasts differentiation [PDF]

, 2018
: Introduction Osteoarthritis (OA) is a degenerative joint disease characterised by articular cartilage and subchondral bone degradation, which affects approximately eight million people in the UK only.
De Pascale, C., Getting, S.J., Locke, I.C.   +2 more
core  

Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo [PDF]

, 2010
NHA2 was recently identified as a novel sodium/hydrogen exchanger which is strongly upregulated during RANKL-induced osteoclast differentiation. Previous in vitro studies suggested that NHA2 is a mitochondrial transporter required for osteoclast ...
Bonny, Olivier, Siegrist, M., Hofstetter, W., Bonny, O., Fuster, Daniel G, Simonin, Alexandre, Simonin, A., Siegrist, Mark, Hofstetter, Willy, Fuster, D.G.   +9 more
core   +1 more source