Results 81 to 90 of about 88,889 (259)

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

BIOMATERIAL PARTICLE PHAGOCYTOSIS BY BONE-RESORBING OSTEOCLASTS

, 1997
Abundant implant-derived biomaterial wear particles are generated in aseptic loosening and are deposited in periprosthetic tissues in which they are phagocytosed by mononuclear and multinucleated macrophage-like cells.
A. H. R. W. Simpson, W. Wang, D. J. P. Ferguson, J. M. W. Quinn, N. A. Athanasou   +4 more
core   +1 more source

Sexual Dimorphism in Osteoclasts

, 2020
Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF ...
Joseph Lorenzo
core   +1 more source

Multi-functional osteoclasts in matrix-based tissue engineering bone

, 2021
The repair of bone defects, especially for the large segment of bone defects, has always been an urgent problem in orthopedic clinic and attracted researchers’ attention.
Yue-Qi Chen, Wen-Hui Hu, Shi-Wu Dong, Dong, Shi-Wu, Hu, Wen-Hui, Dong, Zi-Cai, Chen, Yue-Qi, Zi-Cai Dong   +7 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Characterization of Bovine Osteoclasts on an Ionomeric Cement In Vitro [PDF]

, 1993
Primary bovine osteoclasts were obtained by an outgrowth method from bovine periosteum and cultured for 7 days on an ionomeric cement for biomaterial testing.
Moller, K., Doty, S. B., Szulczewski, D. H., Meyer, U., Stratmann, U., Jones, D. B.   +5 more
core   +1 more source

A novel method to efficiently differentiate human osteoclasts from blood-derived monocytes

Biological Procedures Online
Background Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, they are fundamental for bone physiology in health and disease.
Suganja Chandrabalan, Linh Dang, Uwe Hansen, Melanie Timmen, Corinna Wehmeyer, Richard Stange, Tim Beißbarth, Claudia Binder, Annalen Bleckmann, Kerstin Menck   +9 more
doaj   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

The immunophenotype of osteoclasts and macrophage polykaryons

, 2011
AIM: Osteoclasts are multinucleated cells which are specialised to carry out lacunar bone resorption. Osteoclasts form part of the mononuclear phagocyte system, and immunophenotypic criteria for distinction from macrophage polykaryons include expression ...
Forsyth, R., F. Maggiani, Krenacs , T, Krenacs, T., Hogendoorn , PA, R. Forsyth, N. A. Athanasou, Forsyth , R, T. Krenacs, Athanasou , Nick, Athanasou, N.A., Maggiani, Francesca, Hogendoorn, P.C.W., Maggiani, F., P. C. W. Hogendoorn, F Maggiani   +15 more
core   +1 more source