Results 101 to 110 of about 134,929 (355)

Dlx Homeobox Gene Family Expression in Osteoclasts [PDF]

, 2010
Skeletal growth and homeostasis require the finely orchestrated secretion of mineralized tissue matrices by highly specialized cells, balanced with their degradation by osteoclasts.
Lezot, F., Sharpe, P.T., Grigoriadis, A. E., Castaneda, B., Thomas, B.L., Grigoriadis, A.E., Bolanos, A., Thomas, B. L., Berdal, A., Blin-Wakkach, C., Heymann, D., Carles, G. F., Carles, G.F., Sharpe, P. T., Hotton, D.   +14 more
core   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Connexin-mimetic peptide Gap 27 decreases osteoclastic activity

BMC Musculoskeletal Disorders, 2001
Background Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and that a commonly used gap-junctional ...
Tuukkanen Juha, Tavi Pasi, Ilvesaro Joanna   +2 more
doaj   +1 more source

Mandibular hypertrophic osteodystrophy fibrosa in a german shepherd puppy [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
Hypertrophic osteodystrophy is a developmental disease of unknown etiology and affects primarily young rapidly growing large and giant breed dogs. The present study reports a case of mandibular hypertrophic osteodystrophy fibrosa in a 6-month-old male ...
Elham HASSAN, Faisal TORAD, Ashraf ABU-SEIDA, Azza HASSAN   +3 more
doaj   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Antisense Sense in Osteoclasts [PDF]

The American Journal of Pathology, 2016
This commentary highlights the article by Li et al that proposes regulating Wilm's tumor-1 antisense RNA to control pathological bone resorption.
openaire   +3 more sources

Giant cells around bone biomaterials: Osteoclasts or multi-nucleated giant cells? [PDF]

, 2016
Recently accumulating evidence has put into question the role of large multinucleated giant cells (MNGCs) around bone biomaterials. While cells derived from the monocyte/macrophage lineage are one of the first cell types in contact with implanted ...
Hamoon Zohdi, Masako Fujioka-Kobayashi, Zohdi, Hamoon, Miron, Richard John, Richard J. Miron, Kobayashi, Masako, Bosshardt, Dieter, Dieter D. Bosshardt   +7 more
core   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells

Journal of Experimental Medicine, 2005
Osteoclasts are bone-resorbing cells that play a pivotal role in bone remodeling. Osteoclasts form large multinuclear giant cells by fusion of mononuclear osteoclasts. How cell fusion is mediated, however, is unclear.
M. Yagi, T. Miyamoto, Yumi Sawatani, Katsuya Iwamoto, N. Hosogane, Nobuyuki Fujita, Kozo Morita, Ken Ninomiya, Toru Suzuki, K. Miyamoto, Y. Oike, M. Takeya, Y. Toyama, T. Suda   +13 more
semanticscholar   +1 more source

Giant osteoclasts in patients under bisphosphonates [PDF]

, 2014
International audienceBackground: Bisphosphonates have been widely used for treatment of high bone resorption states. It lowers bone turnover by inhibiting osteoclasts bone resorption with various mechanisms of actions: inhibition of osteoclast formation
Mac-Way, Fabrice, Lafage-Proust, Marie-Hélène, Fabrice Mac-Way, Andrea Trombetti, Trombetti, Andrea, Christian Noel, Marie-Hélène Lafage-Proust, Noel, Christian   +7 more
core   +1 more source