Results 121 to 130 of about 134,929 (355)

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Osteoclast responses to metal ions [PDF]

, 2009
Màster Oficial en Enginyeria BiomèdicaCentral model of the study will be the osteoclast culture on dentin. Osteoclast development from monocytes will be followed biochemically and histologically.
Prehn Gallo, Ricardo
core  

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion

Cells, 2020
Osteoclasts are the sole bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathogenic bone destruction such as inflammatory arthritis.
Peter Sang Uk Park, Se Hwan Mun, Steven L. Zeng, Haemin Kim, Seyeon Bae, Kyung-Hyun Park-Min   +5 more
doaj   +1 more source

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Nature Communications, 2014
The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation.
J. Keller, P. Catalá-Lehnen, A. Huebner, A. Jeschke, T. Heckt, A. Lueth, M. Krause, T. Koehne, J. Albers, J. Schulze, Sarah Schilling, M. Haberland, Hannah Denninger, M. Neven, I. Hermans-Borgmeyer, T. Streichert, S. Breer, F. Barvencik, B. Levkau, B. Rathkolb, E. Wolf, J. Calzada-Wack, F. Neff, V. Gailus-Durner, H. Fuchs, M. H. de Angelis, S. Klutmann, E. Tsourdi, L. Hofbauer, B. Kleuser, J. Chun, T. Schinke, M. Amling   +32 more
semanticscholar   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

The role of MicroRNAs in Osteoclasts and Osteoporosis

RNA Biology, 2014
Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders.
P. Tang, Q. Xiong, Wei Ge, Lihai Zhang
semanticscholar   +1 more source

Ultrastructural Features of Osteoclasts In Situ [PDF]

, 1989
The morphology of in situ osteoclasts on endocortical surfaces of the femoral midshaft was examined by scanning electron microscopy. Mice were perfusion fixed and bone marrow plugs were flushed out of femoral diaphyseal cylinders.
Jee, W. S. S., Miller, S. C., de Saint-Georges, L., Bowman., B. M.   +3 more
core   +1 more source

Isolation of human osteoclasts formed in vitro: hormonal effects on the bone-resorbing activity of human osteoclasts. [PDF]

, 2002
Osteoclasts are multinucleated cells that carry out bone resorption. Analysis of the direct effect of hormones on the bone-resorbing activity of human osteoclasts has been limited by difficulties in isolating these cells from the human skeleton.
Athanasou, NA, Itonaga, I, Sabokbar, A, Pocock, A, Sabokbar, Afsaneh, Kudo, O, Athanasou, Nicholas   +6 more
core   +1 more source

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

Advanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu, Gewei Yan, Zhentao She, Yingzhu He, Kangqi Liu, Jianan Qu   +5 more
wiley   +1 more source