Results 111 to 120 of about 88,889 (259)

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling

Frontiers in Immunology
It is well established that inflammatory processes in the vicinity of bone often induce osteoclast formation and bone resorption. Effects of inflammatory processes on bone formation are less studied.
Petra Henning, Ali Kassem, Anna Westerlund, Pernilla Lundberg, Cecilia Engdahl, Cecilia Engdahl, Vikte Lionikaite, Pernilla Wikström, Jianyao Wu, Lei Li, Catharina Lindholm, Catharina Lindholm, Pedro P. C. de Souza, Sofia Movérare-Skrtic, Ulf H. Lerner, Ulf H. Lerner   +15 more
doaj   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-κB, and MAPK pathways

Frontiers in Pharmacology
Background: Although caffeine generally offers benefits to human health, its impact on bone metabolism remains unclear.Aim and Methods: This study aimed to systematically evaluate the long-term effects of caffeine administration on osteoclasts ...
Yue Miao, Yue Miao, Lei Zhao, Shuwen Lei, Chunyan Zhao, Qiuping Wang, Chao Tan, Chunxiu Peng, Jiashun Gong, Jiashun Gong   +9 more
doaj   +1 more source

Differences in predominant collagen fiber orientation between dorsal and plantar trabecular bone tracts of adult mule deer calcanei suggest strain‐mode‐specific adaptation

The Anatomical Record, EarlyView.
Polarized microscopic images of the outer bone cortex (a and b) and deeper trabecular bone (c and d) of the deer calcaneus in thin cross‐sections. The brighter gray levels reflect more oblique‐to‐transverse collagen fibers in the compression/dorsal bone (a, c) and the darker gray levels reflect more longitudinal collagen in the tension/plantar bone (b,
John G. Skedros, John T. Cronin, Chad S. Mears, Brett W. Richards   +3 more
wiley   +1 more source

Chicken osteoclasts do not possess calcitonin receptors

, 1987
Osteoclasts freshly isolated from embryonic chicks have been examined for calcitonin receptors using radio-iodine-labeled salmon calcitonin. Calcitonin binding to chick osteoclasts could not be shown by either autoradiography or biochemical binding ...
Martin, T.J., Nicholson, G.C., Sexton, P.M.   +2 more
core  

Endocytosis in Odontoclasts and Osteoclasts Using Microperoxidase as a Tracer

, 1990
Microperoxidase (MP, a peptide tracer) was intravenously injected into rats after six days of tooth movement by the Waldo method. Bone resorption was seen along the distal bone surface of the inter-radicular septum of the upper first molar, and tooth ...
N. Ayasaka, T. Jima, T. Morioka, T. Kondo, T. Tanaka   +4 more
core   +1 more source

Integrated microanatomy and microstructure of the maxillary tooth plate reveal a reinforced feeding system and tougher diet in Late Triassic Hyperodapedontinae (Rhynchosauria, Archosauromorpha)

The Anatomical Record, EarlyView.
Abstract Hyperodapedontine rhynchosaurs possessed a unique oral apparatus, long interpreted as an adaptation for processing abrasive and resistant plant material. However, the microanatomical and histological evidence supporting this interpretation remains poorly documented.
Caio A. Scartezini, Pedro L. B. Pruciano, Brodsky D. M. Farias, Marina B. Soares   +3 more
wiley   +1 more source

Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review

Antioxidants
This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for its antimicrobial, anti-inflammatory, and antioxidant properties. Recent research
Vanessa Bertolucci, André Felipe Ninomiya, Giovanna Barbarini Longato, Luisa Oliveira Kaneko, Nilson Nonose, Pedro Paulo Menezes Scariot, Leonardo Henrique Dalcheco Messias   +6 more
doaj   +1 more source

Cortical bone geometry and static gravitational loads in neosauropod dinosaurs: Implications for biomechanical constraints on terrestrial gigantism

The Anatomical Record, EarlyView.
Abstract Sauropod dinosaurs achieved unprecedented terrestrial gigantism, raising questions about the biomechanical limits of bone under extreme gravitational loads. We estimated static gravitational pressures (Pg) on appendicular cortical bone in neosauropods, including diplodocoids, brachiosaurids, and titanosaurs.
Tito Aureliano, Aline M. Ghilardi, Holly N. Woodward, Horácio W. L. Alves, Guilherme M. Sipahi   +4 more
wiley   +1 more source