Results 111 to 120 of about 134,929 (355)

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development

Cellular and Molecular Life Sciences
Aberrant protein regulatory pathways disrupt bone development and contribute to skeletal diseases. The cysteine protease family of deubiquitinating enzymes (DUBs) are critical for regulation of bone-resorbing osteoclasts and bone-forming osteoblasts ...
Sachin Chaugule, Yeon-Suk Yang, Tadatoshi Sato, Emma Mayer, Jae-Hyuck Shim   +4 more
doaj   +1 more source

SLIT2 Overexpression in Periodontitis Intensifies Inflammation and Alveolar Bone Loss, Possibly via the Activation of MAPK Pathway

Frontiers in Cell and Developmental Biology, 2020
SLIT2, a member of neuronal guidance cues, has been reported to regulate inflammation and cancer progression. Periodontitis is an oral inflammatory disease that degenerates periodontal tissue, alveolar bone and tooth.
Liping Wang, Jing Zheng, Janak L. Pathak, Yunxin Chen, Dongliang Liang, Luxi Yang, Haobo Sun, Mei Zhong, Lihong Wu, Li Li, Shuhua Deng, Lingyun Zheng, Yongyong Yan, Dan Hou, Lijing Wang, Lijing Wang, Linhu Ge   +16 more
doaj   +1 more source

Granulocyte-macrophage colony-stimulating factor-dependent CD11c-positive cells differentiate into active osteoclasts. [PDF]

, 2017
Levels of circulating cytokines are elevated in inflammatory diseases. Previously, it was shown that interleukin (IL-)17A, in synergism with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and tumor necrosis factor α (TNFα), induces the release of granulocyte ...
Aeberli, Daniel, Hofstetter, Wilhelm, Seitz, Michael, Dolder, Silvia, Balani, Deepak, Ruef, Nina   +5 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Psoralen and Bakuchiol Ameliorate M-CSF Plus RANKL-Induced Osteoclast Differentiation and Bone Resorption Via Inhibition of AKT and AP-1 Pathways in Vitro

Cellular Physiology and Biochemistry, 2018
Background/Aims: Psoralen and bakuchiol are the main active compounds found in the traditional Chinese medicine Psoralea corylifolia L., and have been used to treat osteoporosis.
Lijuan Chai, Kun Zhou, Shaoxia Wang, Han Zhang, Na Fan, Jie Li, Xiaofeng Tan, Limin Hu, Xiang Fan   +8 more
doaj   +1 more source

The immunophenotype of osteoclasts and macrophage polykaryons [PDF]

, 2011
AIM: Osteoclasts are multinucleated cells which are specialised to carry out lacunar bone resorption. Osteoclasts form part of the mononuclear phagocyte system, and immunophenotypic criteria for distinction from macrophage polykaryons include expression ...
Forsyth, R., F. Maggiani, Krenacs , T, Krenacs, T., Hogendoorn , PA, R. Forsyth, N. A. Athanasou, Athanasou, Nicholas, Forsyth , R, Hogendoorn, PCW, Krenacs, T, Hogendoorn, PC, T. Krenacs, Athanasou , Nick, Athanasou, NA, Athanasou, N.A., Maggiani, Francesca, Hogendoorn, P.C.W., Maggiani, F., P. C. W. Hogendoorn, Maggiani, F, Forsyth, R   +21 more
core   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro.

Biomaterials, 2010
Bioactive glasses (BG) which contain strontium have the potential to combine the known bone regenerative properties of BG with the anabolic and anti-catabolic effects of strontium cations. Here we created a BG series (SiO(2)-P(2)O(5)-Na(2)O-CaO) in which
E. Gentleman, Yann C. Fredholm, G. Jell, N. Lotfibakhshaiesh, M. O'Donnell, R. Hill, M. Stevens   +6 more
semanticscholar   +1 more source

Osteoclasts in RA: Diverse origins and functions [PDF]

, 2013
Osteoclasts were recognized in the late 1990s as the cells responsible for generalized and focal bone loss in rheumatoid arthritis (RA). Concepts about osteoclast biology have changed radically based on recent evidence of considerable diversity in both ...
Heymann, D., Le Goff, B., Berthelot, J-M., Maugars, Y.   +3 more
core   +1 more source