Results 91 to 100 of about 81,648 (311)

Effect of Urocortin on human osteoclasts differentiation

, 2018
: Introduction Osteoarthritis (OA) is a degenerative joint disease characterised by articular cartilage and subchondral bone degradation, which affects approximately eight million people in the UK only.
De Pascale, C., Getting, S.J., Locke, I.C.   +2 more
core  

Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo

, 2010
NHA2 was recently identified as a novel sodium/hydrogen exchanger which is strongly upregulated during RANKL-induced osteoclast differentiation. Previous in vitro studies suggested that NHA2 is a mitochondrial transporter required for osteoclast ...
Bonny, Olivier, Siegrist, M., Hofstetter, W., Bonny, O., Fuster, Daniel G, Simonin, Alexandre, Simonin, A., Siegrist, Mark, Hofstetter, Willy, Fuster, D.G.   +9 more
core   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Calcium signaling in osteoclasts

, 2011
It has long been known that many bone diseases, including osteoporosis, involve abnormalities in osteoclastic bone resorption. As a result, there has been intense study of the mechanisms that regulate both the differentiation and bone resorbing function ...
Putney, James W., Sung-Yong Hwang, James W. Putney, Hwang, Sung-Yong   +3 more
core   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Engineering approaches to manipulate osteoclast behavior for bone regeneration

Materials Today Bio
Extensive research has delved into the multifaceted roles of osteoclasts beyond their traditional function in bone resorption in recent years, uncovering their significant influence on bone formation.
Xin Cheng, Wenzhi Tian, Jianhua Yang, Jiamian Wang, Yang Zhang   +4 more
doaj   +1 more source

Grafting effectiveness of Anadara granosa shell combined with sardinella longiseps gel on the number of osteoblast-osteoclast cells

Dental Journal, 2017
Background: Bone grafts derived from Anadara granosa shells contain calcium carbonate that possesses bone-healing properties. The combination of Sardinella Longiceps fish oil, containing EPA and DHA, and Anadara granosa shells was assumed to regulate the
Eddy Hermanto, Rima Parwati Sari, Asri Cahyadita Dwi Imaniar, Kevin Anggoro   +3 more
doaj   +1 more source

Vitronectin induces podosome belt formation in osteoclasts.

, 2013
Bone marrow-derived osteoclasts were sedimented in MEM/BSA onto glass coverslips that had been coated with the vitronectin or fibronectin at the concentrations shown.
Jade L. Ross (361697), Raymond Moss (361699), Kinga A. Szewczyk (361698), Tim J. Chambers (361700), Karen Fuller (361696)   +4 more
core   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Inhibition of Acid Phosphatase Enzyme Activity in the Presence of Noncrystalline Calcium Phosphate and Nanocrystalline Calcium Apatite: a Preliminary Study

, 2009
*Background* Our bones are remodelled repeatedly during life. A new and “healthy” bone tissue replaces the old one. Accordingly, the bone degrading cells, the osteoclasts, prefer old and fatigued bone.
Yassen Pekounov
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