Results 91 to 100 of about 134,929 (355)
Inhibition of Acid Phosphatase Enzyme Activity in the Presence of Noncrystalline Calcium Phosphate and Nanocrystalline Calcium Apatite: a Preliminary Study [PDF]
, 2009 *Background* Our bones are remodelled repeatedly during life. A new and “healthy” bone tissue replaces the old one. Accordingly, the bone degrading cells, the osteoclasts, prefer old and fatigued bone.
Yassen Pekounov
core +1 more source
Osteoclasts directly influence castration-resistant prostate cancer cells [PDF]
, 2022 Metastasis to bone is the leading cause of death from prostate cancer. Interaction between tumor cells and bone cells can promote progression and influence tumor phenotype.
Damber, Jan-Erik +17 more
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Advanced Science, EarlyView.ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun +10 more
wiley +1 more source
Arthritis Research & Therapy, 2020 Background Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively.
Nazir M. Khan +4 more
doaj +1 more source
Bone Cell Exosomes and Emerging Strategies in Bone Engineering
Biomedicines, 2022 Bone tissue remodeling is a highly regulated process balancing bone formation and resorption through complex cellular crosstalk between resident bone and microenvironment cells.
Sanjana Vig, Maria Helena Fernandes
doaj +1 more source
The role of osteoclasts in bone tissue engineering
Journal of Tissue Engineering and Regenerative Medicine, 2015 The success of scaffold‐based bone regeneration approaches strongly depends on the performance of the biomaterial utilized. Within the efforts of regenerative medicine towards a restitutio ad integrum (i.e.
R. Detsch, A. Boccaccini
semanticscholar +1 more source
Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts [PDF]
, 2010 Despite evidence that DAP12 regulates osteoclasts, mice lacking the ITAM-bearing protein exhibit only mild osteopetrosis. Alternatively, Dap12−/− mice, also lacking FcRγ, are severely osteopetrotic, suggesting that FcRγ compensates for DAP12 deficiency ...
Thomas J. Broekelmann +5 more
core +1 more source
Advanced Science, EarlyView.An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu +10 more
wiley +1 more source
Japanese Journal of Clinical Immunology, 2017 Osteoclasts are differentiated from precursors of the monocyte/macrophage lineage originated from bone marrow hematopoietic stem cells and are the sole bone-resorbing cells in the body. Osteoclast differentiation is thought to require M-CSF (macrophage colony-stimulating factor) and RANKL (receptor activator of nuclear factor kappa-B ligand ...
openaire +3 more sources
Interleukin-32 Promotes Osteoclast Differentiation but Not Osteoclast Activation
PLoS ONE, 2009 Interleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently reported its effect on the osteoclastogenesis process remains unclear.In the present study, we have shown that IL ...
Mabilleau, Guillaume, Sabokbar, Afsie
openaire +5 more sources