Results 61 to 70 of about 134,929 (355)
Sexual Dimorphism in Osteoclasts [PDF]
, 2020 Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF ...
Joseph Lorenzo
core +1 more source
Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly
mBio, 2019 The inflammation of bone tissue is called osteomyelitis, and most cases are caused by an infection with the bacterium Staphylococcus aureus. To date, the bone-building cells, osteoblasts, have been implicated in the progression of these infections, but ...
Jennifer L. Krauss +8 more
semanticscholar +1 more source
Osteoclast Fusion and Fission [PDF]
Calcified Tissue International, 2012 Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C. +4 more
openaire +6 more sources
Regulation of Osteoclast Differentiation by Myosin X
Scientific Reports, 2017 Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known.
Amy Tasca +6 more
doaj +1 more source
THOC5 regulates human osteoclastogenesis
European Journal of Cell Biology, 2022 Osteoclasts are bone resorbing cells that are responsible for physiological and pathological bone resorption. Macrophage colony stimulating factor (M-CSF) binds to the M-CSF receptor (c-FMS) and plays a key role in the differentiation and survival of ...
Se Hwan Mun +5 more
doaj +1 more source
The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone
International Journal of Molecular Sciences, 2018 Osteoclasts form a specialized cell–matrix adhesion structure, known as the “sealing zone”, during bone resorption. The sealing zone is a dynamic actin-rich structure that defines the resorption area of the bone.
J. Takito, S. Inoue, Masanori Nakamura
semanticscholar +1 more source
ANGPTL4 is expressed by osteoclasts in RA. [PDF]
, 2014 (A) ANGPTL4 is strongly expressed by osteoclasts (arrows) in the RA synovium. Inset: Representative isotype control image. (B) Resorbing osteoclasts adjacent to bone (starred) express ANGPTL4.
Nicholas A. Athanasou (632663) +2 more
core +1 more source
Plasminogen activator system in osteoclasts [PDF]
, 1997 To determine which genes of the plasminogen activator (PA) system were expressed in osteoclasts, RNA extracted from microisolated mouse osteoclasts was used as template for reverse transcribed polymerase chain reaction (RT-PCR) with gene-specific primer ...
J.‐N. Yang +9 more
core +1 more source
Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Advanced Materials, EarlyView.Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
Spine Surgery and Related Research, 2019 Introduction: Causes of pain due to spinal metastases have been insufficiently investigated. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were the focus of this study.
Ai Mazaki +10 more
doaj +1 more source