Results 61 to 70 of about 81,648 (311)
Arthritis Research & Therapy, 2020 Background Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively.
Nazir M. Khan +4 more
doaj +1 more source
Bone Cell Exosomes and Emerging Strategies in Bone Engineering
Biomedicines, 2022 Bone tissue remodeling is a highly regulated process balancing bone formation and resorption through complex cellular crosstalk between resident bone and microenvironment cells.
Sanjana Vig, Maria Helena Fernandes
doaj +1 more source
T cell suppression by osteoclasts in vitro
, 2011 T cells are critical regulators of osteoclast differentiation and function in bone, but whether osteoclasts can, in turn, regulate T cell homing, and response to stimuli is unclear.
FACCHINI, ANDREA +6 more
core +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
, 1992 Macrophage colony-stimulating factor (M-CSF), whose action is restricted to the cell populations of the mononuclear phagocyte system, has recently been found to be required for osteoclastogenesis and bone resorption.
Mueller, C +11 more
core +1 more source
Antisense Sense in Osteoclasts [PDF]
The American Journal of Pathology, 2016 This commentary highlights the article by Li et al that proposes regulating Wilm's tumor-1 antisense RNA to control pathological bone resorption.
openaire +3 more sources
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Connexin-mimetic peptide Gap 27 decreases osteoclastic activity
BMC Musculoskeletal Disorders, 2001 Background Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and that a commonly used gap-junctional ...
Tuukkanen Juha +2 more
doaj +1 more source
Mandibular hypertrophic osteodystrophy fibrosa in a german shepherd puppy [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019 Hypertrophic osteodystrophy is a developmental disease of unknown etiology and affects primarily young rapidly growing large and giant breed dogs. The present study reports a case of mandibular hypertrophic osteodystrophy fibrosa in a 6-month-old male ...
Elham HASSAN +3 more
doaj +1 more source
Osteoclasts in Health and Disease
, 2019 Osteoclasts are multinucleated, giant cells originating from myeloid hematopoetic stem cells. These are the only cells in nature which can resorb bone.
Lerner, Ulf H,
core +1 more source