Results 21 to 30 of about 1,264,713 (295)
The impacts of exosomes on bone metastatic progression and their potential clinical utility
Bone Reports, 2022 Bone is one of the most common sites of cancer metastasis. Once cancer metastasizes to the bone, the mortality rate of cancer patients dramatically increases. Although the exact mechanisms for this observation remain elusive, recent studies have revealed
Jenna Ollodart +3 more
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The Role of the Immune Microenvironment in Bone Regeneration [PDF]
International Journal of Medical Sciences, 2021 Bone is an active tissue, being constantly renewed in healthy individuals with participation of the immune system to a large extent. Any imbalance between the processes of bone formation and bone resorption is linked to various inflammatory bone diseases. The immune system plays an important role in tissue formation and bone resorption.
Yang, Ning, Liu, Yao
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WHIM Syndrome-linked CXCR4 mutations drive osteoporosis
Nature Communications, 2023 WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mouse model.
Adrienne Anginot +25 more
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Exploration of Targeted Anti-tumor Therapy, 2021 Intracellular Ca2+ ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of fundamental cellular physiology such as gene expression, cell division ...
Manh Tien Tran
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Subchondral bone microenvironment in osteoarthritis and pain [PDF]
Bone Research, 2021 AbstractOsteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain, causing disability and economic burden. The incidence of osteoarthritis is rapidly increasing worldwide due to aging and obesity trends.
Yan Hu +4 more
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Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration
Stem Cells International, 2021 The microenvironment, or niche, regulates stem cell fate and improves differentiation efficiency. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are ideal cell source for bone tissue engineering.
Lingling E +11 more
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Frontiers in Oncology, 2021 Patients with metastatic prostate cancer frequently develop bone metastases that elicit significant skeletal morbidity and increased mortality. The high tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic-like ...
Giulia Ribelli +8 more
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Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]
, 2005 Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Moser, C. +4 more
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Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering [PDF]
, 2010 Mesenchymal stem/stromal cells (MSC) are typically used to generate bone tissue by a process resembling intramembranous ossification, i.e., by direct osteoblastic differentiation.
Schaeren, Stefan +9 more
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, 2023 Chemoresistance is a significant problem in the effective treatment of bone metastasis. Adipocytes are a major stromal cell type in the bone marrow and may play a crucial role in developing microenvironment-driven chemoresistance.
Jun-Goo Kwak, Jungwoo Lee
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