Results 11 to 20 of about 1,264,713 (295)

Acidic microenvironment and bone pain in cancer-colonized bone [PDF]

BoneKEy Reports, 2015
Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-related complications. Bone pain is one of the most common complications associated with cancer colonization in bone and a major cause of increased morbidity and ...
Okui, Tatsuo, Nagata, Yuki, Hiasa, Masahiro, White, Fletcher A., Yoneda, Toshiyuki   +4 more
core   +3 more sources

Bone marrow microenvironment and tumor progression [PDF]

Cancer Microenvironment, 2008
The bone marrow constitutes an unique microenvironment for cancer cells in three specific aspects. First, the bone marrow actively recruits circulating tumor cells where they find a sanctuary rich in growth factors and cytokines that promote their ...
Chantrain, Christophe, Marbaix, Etienne, DeClerck, Yves A, Olivier Feron, Christophe F. Chantrain, Yves A. DeClerck, Etienne Marbaix, Feron, Olivier   +7 more
core   +4 more sources

Acid Microenvironment in Bone Sarcomas [PDF]

Cancers, 2021
In bone sarcomas, extracellular proton accumulation is an intrinsic driver of malignancy. Extracellular acidosis increases stemness, invasion, angiogenesis, metastasis, and resistance to therapy of cancer cells. It reprograms tumour-associated stroma into a protumour phenotype through the release of inflammatory cytokines.
Di Pompo G., Cortini M., Baldini N., Avnet S.   +3 more
openaire   +3 more sources

Metabolism in the Tumour-Bone Microenvironment [PDF]

Current Osteoporosis Reports, 2021
Abstract Purpose of Review For solid tumours such as breast and prostate cancer, and haematological malignancies such as myeloma, bone represents a supportive home, where the cellular crosstalk is known to underlie both tumour growth and survival, and the development of the associated bone disease.
Jessica Whitburn, Claire M. Edwards
openaire   +2 more sources

Cancer Cell Dormancy in the Bone Microenvironment. [PDF]

Curr Osteoporos Rep
Abstract Purpose of the Review Cancer cell dormancy in the bone microenvironment presents a major obstacle to curative therapy across multiple cancer types. The bone harbours specialised pro-dormancy niches that promote the induction and long-term maintenance of dormant cancer cells.
Harris CJ, Stewart GR, Foston A, Green AC.   +3 more
europepmc   +5 more sources

Mimicking bone microenvironment : 2D and 3D in vitro models of human osteoblasts [PDF]

, 2021
Understanding the in vitro biology and behavior of human osteoblasts is crucial for developing research models that reproduce closely the bone structure, its functions, and the cell-cell and cell-matrix interactions that occurs in vivo.
Serrano, D. R., Yuste, I., Luciano, F. C., González-Burgos, E., Lalatsa, A.   +4 more
core   +2 more sources

Inflammatory bone marrow microenvironment [PDF]

Hematology, 2019
Abstract Self-renewing hematopoietic stem cells and their progeny, lineage-specific downstream progenitors, maintain steady-state hematopoiesis in the bone marrow (BM). Accumulating evidence over the last few years indicates that not only primitive hematopoietic stem and progenitor cells (HSPCs), but also cells defining the ...
Leimkühler, Nils B., Schneider, Rebekka K.   +1 more
openaire   +2 more sources

Effects of erythropoietin on the bone microenvironment [PDF]

Growth Factors, 2011
It has been well established that blood and bone share a unique, regulatory relationship with one another, though the specifics of this relationship still remain unanswered. Erythropoietin (Epo) is known primarily for its role as a hematopoietic hormone. However, after the discovery of Epo receptor outside the hematopoietic tissues, Epo has been avidly
S J, McGee, A M, Havens, Y, Shiozawa, Y, Jung, R S, Taichman   +4 more
openaire   +2 more sources

Dissecting the effects of ²²³Radium on the bone microenvironment. [PDF]

Acta Pharm Sin B
Radium-223 (223Ra) is a bone-seeking, alpha-particle-emitting radionuclide that is approved for the treatment of patients with metastatic prostate cancer and is currently being tested in clinical trials for primary and metastatic cancers to the bone.
Barrios S, Serafini E, La Posta L, Meyers DN, Dunbar NJ, Corn PG, Elefteriou F, Ambrose CG, Casarin S, Mikos AG, Dondossola E.   +10 more
europepmc   +3 more sources

The Bone Marrow Microenvironment in B-Cell Development and Malignancy

, 2022
SIMPLE SUMMARY: B cells are an essential component of the immune system and develop in the bone marrow microenvironment. B-cell development is tightly regulated by the stromal cells, fat cells and bone cells in this microenvironment. However, when B-cell
Anastasia M. Hughes, Vincent Kuek, Rishi S. Kotecha, Kuek, Vincent, Cheung, Laurence C., Kotecha, Rishi S., Hughes, Anastasia M., Laurence C. Cheung   +7 more
core   +1 more source